Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease

Ellen Grober, Charles B. Hall, Richard B. Lipton, Alan B. Zonderman, Susan M. Resnick, Claudia Kawas

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

In the Baltimore Longitudinal Study of Aging (BLSA), we examined the temporal unfolding of declining performance on tests of episodic memory (Free Recall on the Free and Cued Selective Reminding Test), executive function (Category Fluency, Letter Fluency, and Trails), and Verbal Intelligence (Nelson, 1982; American Version of the Nelson Adult Reading Test [AMNART]) before the diagnosis of dementia in 92 subjects with incident Alzheimer's disease (AD) followed for up to 15 years before diagnosis. To examine the preclinical onset of cognitive decline, we aligned subjects at the time of initial AD diagnosis and examined the cognitive course preceding diagnosis. We found that declines in performance on tests of episodic memory accelerated 7 years before diagnosis. Declining performance on tests of executive function accelerated 2-3 years before diagnosis, and verbal intelligence declined in close proximity to diagnosis. This cognitive profile is compatible with pathologic data suggesting that structures which mediate memory are affected earlier than frontal structures during the preclinical onset of AD. It also supports the view that VIQ as estimated by the AMNART does not decline during the preclinical onset of AD.

Original languageEnglish (US)
Pages (from-to)266-278
Number of pages13
JournalJournal of the International Neuropsychological Society
Volume14
Issue number2
DOIs
StatePublished - Mar 2008

Fingerprint

Alzheimer Disease
Episodic Memory
Executive Function
Intelligence
Reading
Baltimore
Longitudinal Studies
Dementia

Keywords

  • Alzheimer's disease
  • Cognition disorders
  • Memory disorders
  • Preclinical dementia
  • Prospective studies
  • Verbal learning

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease. / Grober, Ellen; Hall, Charles B.; Lipton, Richard B.; Zonderman, Alan B.; Resnick, Susan M.; Kawas, Claudia.

In: Journal of the International Neuropsychological Society, Vol. 14, No. 2, 03.2008, p. 266-278.

Research output: Contribution to journalArticle

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