Memory CD8+ T Cells: Innate-Like Sensors and Orchestrators of Protection

Gregoire Lauvau, Marie Boutet, Tere M. Williams, Shu Shien Chin, Laurent Chorro

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Recent findings have revealed roles for systemic and mucosa-resident memory CD8+ T cells in the orchestration of innate immune responses critical to host defense upon microbial infection. Here we integrate these findings into the current understanding of the molecular and cellular signals controlling memory CD8+ T cell reactivation and the mechanisms by which these cells mediate effective protection in vivo. The picture that emerges presents memory CD8+ T cells as early sensors of danger signals, mediating protective immunity both through licensing of cellular effectors of the innate immune system and via the canonical functions associated with memory T cells. We discuss implications for the development of T cell vaccines and therapies and highlight important areas in need of further investigation.

Original languageEnglish (US)
Pages (from-to)375-385
Number of pages11
JournalTrends in Immunology
Volume37
Issue number6
DOIs
StatePublished - Jun 1 2016

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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