Memory CD8+ T Cells

Innate-Like Sensors and Orchestrators of Protection

Gregoire Lauvau, Marie Boutet, Tere M. Williams, Shu Shien Chin, Laurent Chorro

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Recent findings have revealed roles for systemic and mucosa-resident memory CD8+ T cells in the orchestration of innate immune responses critical to host defense upon microbial infection. Here we integrate these findings into the current understanding of the molecular and cellular signals controlling memory CD8+ T cell reactivation and the mechanisms by which these cells mediate effective protection in vivo. The picture that emerges presents memory CD8+ T cells as early sensors of danger signals, mediating protective immunity both through licensing of cellular effectors of the innate immune system and via the canonical functions associated with memory T cells. We discuss implications for the development of T cell vaccines and therapies and highlight important areas in need of further investigation.

Original languageEnglish (US)
Pages (from-to)375-385
Number of pages11
JournalTrends in Immunology
Volume37
Issue number6
DOIs
StatePublished - Jun 1 2016

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T-Lymphocytes
Active Immunotherapy
Licensure
Cell- and Tissue-Based Therapy
Innate Immunity
Immune System
Immunity
Mucous Membrane
Infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Memory CD8+ T Cells : Innate-Like Sensors and Orchestrators of Protection. / Lauvau, Gregoire; Boutet, Marie; Williams, Tere M.; Chin, Shu Shien; Chorro, Laurent.

In: Trends in Immunology, Vol. 37, No. 6, 01.06.2016, p. 375-385.

Research output: Contribution to journalReview article

Lauvau, Gregoire ; Boutet, Marie ; Williams, Tere M. ; Chin, Shu Shien ; Chorro, Laurent. / Memory CD8+ T Cells : Innate-Like Sensors and Orchestrators of Protection. In: Trends in Immunology. 2016 ; Vol. 37, No. 6. pp. 375-385.
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