Abstract
We assessed the relationships of performance on memory and mental status tests and neuropathologic stage of Alzheimer's disease as defined by Braak and Braak in 29 patients from a prospective clinicopathologic series. We predicted that memory changes would occur at an earlier Braak stage than mental status changes. Staging was accomplished by matching the topographic distribution of neurofibrillary lesions detected with tau immunocytochemistry to the best fitting diagram published by Braak and Braak. Higher Braak stages were associated with decrements in performance on both memory and mental status tests. As predicted, memory performance declined from stages II to III and mental status did not decline until stages III to IV. The association between memory and Braak stage was unchanged after adjusting for neocortical senile plaques, whereas adjustments for Braak stage eliminated the association between cognitive functioning and amyloid burden. We conclude that Braak staging provides a useful summary of Alzheimer's disease neuropathology, which is associated with both memory and mental status performance. Copyright (C) 1999 Elsevier Science Inc.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 573-579 |
| Number of pages | 7 |
| Journal | Neurobiology of Aging |
| Volume | 20 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1999 |
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Keywords
- Alzheimer's disease
- Braak stage
- Memory
- Mental status
ASJC Scopus subject areas
- Clinical Neurology
- Biological Psychiatry
- Developmental Neuroscience
- Neurology
- Psychology(all)
Cite this
Memory and mental status correlates of modified Braak staging. / Grober, E.; Dickson, D.; Sliwinski, M. J.; Buschke, Herman; Katz, Mindy Joy; Crystal, H.; Lipton, Richard B.
In: Neurobiology of Aging, Vol. 20, No. 6, 11.1999, p. 573-579.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Memory and mental status correlates of modified Braak staging
AU - Grober, E.
AU - Dickson, D.
AU - Sliwinski, M. J.
AU - Buschke, Herman
AU - Katz, Mindy Joy
AU - Crystal, H.
AU - Lipton, Richard B.
PY - 1999/11
Y1 - 1999/11
N2 - We assessed the relationships of performance on memory and mental status tests and neuropathologic stage of Alzheimer's disease as defined by Braak and Braak in 29 patients from a prospective clinicopathologic series. We predicted that memory changes would occur at an earlier Braak stage than mental status changes. Staging was accomplished by matching the topographic distribution of neurofibrillary lesions detected with tau immunocytochemistry to the best fitting diagram published by Braak and Braak. Higher Braak stages were associated with decrements in performance on both memory and mental status tests. As predicted, memory performance declined from stages II to III and mental status did not decline until stages III to IV. The association between memory and Braak stage was unchanged after adjusting for neocortical senile plaques, whereas adjustments for Braak stage eliminated the association between cognitive functioning and amyloid burden. We conclude that Braak staging provides a useful summary of Alzheimer's disease neuropathology, which is associated with both memory and mental status performance. Copyright (C) 1999 Elsevier Science Inc.
AB - We assessed the relationships of performance on memory and mental status tests and neuropathologic stage of Alzheimer's disease as defined by Braak and Braak in 29 patients from a prospective clinicopathologic series. We predicted that memory changes would occur at an earlier Braak stage than mental status changes. Staging was accomplished by matching the topographic distribution of neurofibrillary lesions detected with tau immunocytochemistry to the best fitting diagram published by Braak and Braak. Higher Braak stages were associated with decrements in performance on both memory and mental status tests. As predicted, memory performance declined from stages II to III and mental status did not decline until stages III to IV. The association between memory and Braak stage was unchanged after adjusting for neocortical senile plaques, whereas adjustments for Braak stage eliminated the association between cognitive functioning and amyloid burden. We conclude that Braak staging provides a useful summary of Alzheimer's disease neuropathology, which is associated with both memory and mental status performance. Copyright (C) 1999 Elsevier Science Inc.
KW - Alzheimer's disease
KW - Braak stage
KW - Memory
KW - Mental status
UR - http://www.scopus.com/inward/record.url?scp=0033394155&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033394155&partnerID=8YFLogxK
U2 - 10.1016/S0197-4580(99)00063-9
DO - 10.1016/S0197-4580(99)00063-9
M3 - Article
C2 - 10674422
AN - SCOPUS:0033394155
VL - 20
SP - 573
EP - 579
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 6
ER -