Membrane transporters and folate homeostasis

Intestinal absorption and transport into systemic compartments and tissues

Rongbao Zhao, Larry H. Matherly, I. David Goldman

Research output: Contribution to journalArticle

216 Citations (Scopus)

Abstract

Members of the family of B9 vitamins are commonly known as folates. They are derived entirely from dietary sources and are key one-carbon donors required for de novo nucleotide and methionine synthesis. These highly hydrophilic molecules use several genetically distinct and functionally diverse transport systems to enter cells: the reduced folate carrier, the proton-coupled folate transporter and the folate receptors. Each plays a unique role in mediating folate transport across epithelia and into systemic tissues. The mechanism of intestinal folate absorption was recently uncovered, revealing the genetic basis for the autosomal recessive disorder hereditary folate malabsorption, which results from loss-of-function mutations in the proton-coupled folate transporter gene. It is therefore now possible to piece together how these folate transporters contribute, both individually and collectively, to folate homeostasis in humans. This review focuses on the physiological roles of the major folate transporters, with a brief consideration of their impact on the pharmacological activities of antifolates.

Original languageEnglish (US)
Article numbere4
JournalExpert Reviews in Molecular Medicine
Volume11
DOIs
StatePublished - Dec 2009

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Membrane Transport Proteins
Intestinal Absorption
Folic Acid
Homeostasis
Proton-Coupled Folate Transporter
Folic Acid Transporters
Reduced Folate Carrier Protein
Folic Acid Antagonists
Methionine
Carbon
Epithelium
Nucleotides
Pharmacology
Mutation
Genes

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

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