Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels

Inmaculada Tasset, Eduardo Agüera, Rosa Olmo-Camacho, Begoña Escribano, Fernando Sánchez-López, María J. Delgado, Antonio H. Cruz, Felix Gascón, Evelio Luque, José Peña, Ignacio M. Jimena, Isaac Túnez

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: This study sought to determine whether melatonin causes changes in neurotrophic factors and it protects against the mycotoxin 3-nitropropionic acid (3-NP) in brain tissue. Methods: Rats were given 3-NP over four consecutive days (20. mg/kg BW), while melatonin was administered over 21. days (1. mg/kg/BW), starting after the last injection of 3-NP. Results: Rats treated with 3-NP displayed significant changes in neurotrophic factor (BDNF and GDNF) levels, together with alterations in behavior; they also displayed extensive oxidative stress and a massive neuronal damage. Conclusions: Melatonin improved behavioral alterations, reduced oxidative damage, lowered neurotrophic factor levels and neuronal loss in 3-NP-treated rats. These results suggest that melatonin exerts a neuroprotective action.

Original languageEnglish (US)
Pages (from-to)1944-1949
Number of pages6
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume35
Issue number8
DOIs
StatePublished - Dec 1 2011
Externally publishedYes

Fingerprint

Nerve Growth Factors
Melatonin
Glial Cell Line-Derived Neurotrophic Factor
Mycotoxins
Brain-Derived Neurotrophic Factor
Oxidative Stress
3-nitropropionic acid
Injections
Brain

Keywords

  • Cell damage
  • Huntington's disease
  • Melatonin
  • Neuroplasticity
  • Neuroprotective
  • Neurotrophic factors

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Cite this

Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels. / Tasset, Inmaculada; Agüera, Eduardo; Olmo-Camacho, Rosa; Escribano, Begoña; Sánchez-López, Fernando; Delgado, María J.; Cruz, Antonio H.; Gascón, Felix; Luque, Evelio; Peña, José; Jimena, Ignacio M.; Túnez, Isaac.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 35, No. 8, 01.12.2011, p. 1944-1949.

Research output: Contribution to journalArticle

Tasset, I, Agüera, E, Olmo-Camacho, R, Escribano, B, Sánchez-López, F, Delgado, MJ, Cruz, AH, Gascón, F, Luque, E, Peña, J, Jimena, IM & Túnez, I 2011, 'Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 35, no. 8, pp. 1944-1949. https://doi.org/10.1016/j.pnpbp.2011.09.005
Tasset, Inmaculada ; Agüera, Eduardo ; Olmo-Camacho, Rosa ; Escribano, Begoña ; Sánchez-López, Fernando ; Delgado, María J. ; Cruz, Antonio H. ; Gascón, Felix ; Luque, Evelio ; Peña, José ; Jimena, Ignacio M. ; Túnez, Isaac. / Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2011 ; Vol. 35, No. 8. pp. 1944-1949.
@article{1c8639de06a942798e1844b1d8c00ff2,
title = "Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels",
abstract = "Objective: This study sought to determine whether melatonin causes changes in neurotrophic factors and it protects against the mycotoxin 3-nitropropionic acid (3-NP) in brain tissue. Methods: Rats were given 3-NP over four consecutive days (20. mg/kg BW), while melatonin was administered over 21. days (1. mg/kg/BW), starting after the last injection of 3-NP. Results: Rats treated with 3-NP displayed significant changes in neurotrophic factor (BDNF and GDNF) levels, together with alterations in behavior; they also displayed extensive oxidative stress and a massive neuronal damage. Conclusions: Melatonin improved behavioral alterations, reduced oxidative damage, lowered neurotrophic factor levels and neuronal loss in 3-NP-treated rats. These results suggest that melatonin exerts a neuroprotective action.",
keywords = "Cell damage, Huntington's disease, Melatonin, Neuroplasticity, Neuroprotective, Neurotrophic factors",
author = "Inmaculada Tasset and Eduardo Ag{\"u}era and Rosa Olmo-Camacho and Bego{\~n}a Escribano and Fernando S{\'a}nchez-L{\'o}pez and Delgado, {Mar{\'i}a J.} and Cruz, {Antonio H.} and Felix Gasc{\'o}n and Evelio Luque and Jos{\'e} Pe{\~n}a and Jimena, {Ignacio M.} and Isaac T{\'u}nez",
year = "2011",
month = "12",
day = "1",
doi = "10.1016/j.pnpbp.2011.09.005",
language = "English (US)",
volume = "35",
pages = "1944--1949",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Melatonin improves 3-nitropropionic acid induced behavioral alterations and neurotrophic factors levels

AU - Tasset, Inmaculada

AU - Agüera, Eduardo

AU - Olmo-Camacho, Rosa

AU - Escribano, Begoña

AU - Sánchez-López, Fernando

AU - Delgado, María J.

AU - Cruz, Antonio H.

AU - Gascón, Felix

AU - Luque, Evelio

AU - Peña, José

AU - Jimena, Ignacio M.

AU - Túnez, Isaac

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Objective: This study sought to determine whether melatonin causes changes in neurotrophic factors and it protects against the mycotoxin 3-nitropropionic acid (3-NP) in brain tissue. Methods: Rats were given 3-NP over four consecutive days (20. mg/kg BW), while melatonin was administered over 21. days (1. mg/kg/BW), starting after the last injection of 3-NP. Results: Rats treated with 3-NP displayed significant changes in neurotrophic factor (BDNF and GDNF) levels, together with alterations in behavior; they also displayed extensive oxidative stress and a massive neuronal damage. Conclusions: Melatonin improved behavioral alterations, reduced oxidative damage, lowered neurotrophic factor levels and neuronal loss in 3-NP-treated rats. These results suggest that melatonin exerts a neuroprotective action.

AB - Objective: This study sought to determine whether melatonin causes changes in neurotrophic factors and it protects against the mycotoxin 3-nitropropionic acid (3-NP) in brain tissue. Methods: Rats were given 3-NP over four consecutive days (20. mg/kg BW), while melatonin was administered over 21. days (1. mg/kg/BW), starting after the last injection of 3-NP. Results: Rats treated with 3-NP displayed significant changes in neurotrophic factor (BDNF and GDNF) levels, together with alterations in behavior; they also displayed extensive oxidative stress and a massive neuronal damage. Conclusions: Melatonin improved behavioral alterations, reduced oxidative damage, lowered neurotrophic factor levels and neuronal loss in 3-NP-treated rats. These results suggest that melatonin exerts a neuroprotective action.

KW - Cell damage

KW - Huntington's disease

KW - Melatonin

KW - Neuroplasticity

KW - Neuroprotective

KW - Neurotrophic factors

UR - http://www.scopus.com/inward/record.url?scp=82455175306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82455175306&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2011.09.005

DO - 10.1016/j.pnpbp.2011.09.005

M3 - Article

C2 - 21939726

AN - SCOPUS:82455175306

VL - 35

SP - 1944

EP - 1949

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

IS - 8

ER -