Melanins are dark pigments that are made by diverse fungi (1, 2). Even fungi that produce white colonies, such as Candida albicans, have the ability to make melanins (3, 4). Melanins have elicited considerable interest in microbial pathogenesis because they are important virulence factors for many pathogenic microbes, and their presence is associated with reduced susceptibility to antifungal drugs (5, 6). Melanins are multifunctional molecules that give cells structural strength as well as reduced susceptibility to temperature extremes, heavy metals, and molecules produced by the immune system such as oxygen- and nitrogen-derived oxidants and microbicidal proteins (2, 7 - 10).
- Candida albicans
- Electromagnetic radiation
- Metabolic change
- Radiation-extreme environment
ASJC Scopus subject areas
- Immunology and Microbiology(all)