Melancholia and axis II comorbidity

Joyce Tedlow, Megan Smith, Nicole Neault, Laura Polania, Jonathan E. Alpert, Andrew Nierenberg, Maurizio Fava

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

This study assessed whether the rates of comorbid personality disorders differed between DSM-IV melancholic and nonmelancholic major depressive disorder. We evaluated 260 consecutive depressed outpatients (140 women [53.8%]; mean age, 39.01 ± 10.4 years) with DSM-III-R major depressive disorder (MDD). MDD was diagnosed with the use of the Structured Clinical Interview for DSM-III-R-Patient Edition (SCID-P); enrolled patients were required to have a score ≥ 16 on the 17-item Hamilton Rating Scale for Depression (HAM-D-17). The presence of the melancholic subtype of major depression was determined with the use of a DSM-IV checklist, while the presence of personality disorders was assessed using the Structured Clinical Interview for DSM-III-R-Personality Disorders (SCID-II). Of the 102 (39.2%) patients who met criteria for melancholic depression and the 158 (60.7%) who did not, there were no significant differences in age, gender, or rates of personality disorder diagnoses. We observed no significant difference in rates of individual personality disorder clusters between melancholic and nonmelancholic depressed patients. Our findings of comparable rates of comorbid personality disorders between melancholic and nonmelancholic depression are consistent with the decision made by the DSM-IV task force to drop the DSM-III-R melancholic feature criterion of "no significant personality disturbance before first major depressive episode" as they challenge the usefulness of trying to establish such absence of premorbid personality features in acutely depressed patients.

Original languageEnglish (US)
Pages (from-to)331-335
Number of pages5
JournalComprehensive Psychiatry
Volume43
Issue number5
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Depressive Disorder
Personality Disorders
Diagnostic and Statistical Manual of Mental Disorders
Comorbidity
Major Depressive Disorder
Depression
Personality
Interviews
Advisory Committees
Checklist
Outpatients

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Tedlow, J., Smith, M., Neault, N., Polania, L., Alpert, J. E., Nierenberg, A., & Fava, M. (2002). Melancholia and axis II comorbidity. Comprehensive Psychiatry, 43(5), 331-335. https://doi.org/10.1053/comp.2002.34631

Melancholia and axis II comorbidity. / Tedlow, Joyce; Smith, Megan; Neault, Nicole; Polania, Laura; Alpert, Jonathan E.; Nierenberg, Andrew; Fava, Maurizio.

In: Comprehensive Psychiatry, Vol. 43, No. 5, 2002, p. 331-335.

Research output: Contribution to journalArticle

Tedlow, J, Smith, M, Neault, N, Polania, L, Alpert, JE, Nierenberg, A & Fava, M 2002, 'Melancholia and axis II comorbidity', Comprehensive Psychiatry, vol. 43, no. 5, pp. 331-335. https://doi.org/10.1053/comp.2002.34631
Tedlow J, Smith M, Neault N, Polania L, Alpert JE, Nierenberg A et al. Melancholia and axis II comorbidity. Comprehensive Psychiatry. 2002;43(5):331-335. https://doi.org/10.1053/comp.2002.34631
Tedlow, Joyce ; Smith, Megan ; Neault, Nicole ; Polania, Laura ; Alpert, Jonathan E. ; Nierenberg, Andrew ; Fava, Maurizio. / Melancholia and axis II comorbidity. In: Comprehensive Psychiatry. 2002 ; Vol. 43, No. 5. pp. 331-335.
@article{53cad921a39f4c0ba547f33f6bcd4999,
title = "Melancholia and axis II comorbidity",
abstract = "This study assessed whether the rates of comorbid personality disorders differed between DSM-IV melancholic and nonmelancholic major depressive disorder. We evaluated 260 consecutive depressed outpatients (140 women [53.8{\%}]; mean age, 39.01 ± 10.4 years) with DSM-III-R major depressive disorder (MDD). MDD was diagnosed with the use of the Structured Clinical Interview for DSM-III-R-Patient Edition (SCID-P); enrolled patients were required to have a score ≥ 16 on the 17-item Hamilton Rating Scale for Depression (HAM-D-17). The presence of the melancholic subtype of major depression was determined with the use of a DSM-IV checklist, while the presence of personality disorders was assessed using the Structured Clinical Interview for DSM-III-R-Personality Disorders (SCID-II). Of the 102 (39.2{\%}) patients who met criteria for melancholic depression and the 158 (60.7{\%}) who did not, there were no significant differences in age, gender, or rates of personality disorder diagnoses. We observed no significant difference in rates of individual personality disorder clusters between melancholic and nonmelancholic depressed patients. Our findings of comparable rates of comorbid personality disorders between melancholic and nonmelancholic depression are consistent with the decision made by the DSM-IV task force to drop the DSM-III-R melancholic feature criterion of {"}no significant personality disturbance before first major depressive episode{"} as they challenge the usefulness of trying to establish such absence of premorbid personality features in acutely depressed patients.",
author = "Joyce Tedlow and Megan Smith and Nicole Neault and Laura Polania and Alpert, {Jonathan E.} and Andrew Nierenberg and Maurizio Fava",
year = "2002",
doi = "10.1053/comp.2002.34631",
language = "English (US)",
volume = "43",
pages = "331--335",
journal = "Comprehensive Psychiatry",
issn = "0010-440X",
publisher = "W.B. Saunders Ltd",
number = "5",

}

TY - JOUR

T1 - Melancholia and axis II comorbidity

AU - Tedlow, Joyce

AU - Smith, Megan

AU - Neault, Nicole

AU - Polania, Laura

AU - Alpert, Jonathan E.

AU - Nierenberg, Andrew

AU - Fava, Maurizio

PY - 2002

Y1 - 2002

N2 - This study assessed whether the rates of comorbid personality disorders differed between DSM-IV melancholic and nonmelancholic major depressive disorder. We evaluated 260 consecutive depressed outpatients (140 women [53.8%]; mean age, 39.01 ± 10.4 years) with DSM-III-R major depressive disorder (MDD). MDD was diagnosed with the use of the Structured Clinical Interview for DSM-III-R-Patient Edition (SCID-P); enrolled patients were required to have a score ≥ 16 on the 17-item Hamilton Rating Scale for Depression (HAM-D-17). The presence of the melancholic subtype of major depression was determined with the use of a DSM-IV checklist, while the presence of personality disorders was assessed using the Structured Clinical Interview for DSM-III-R-Personality Disorders (SCID-II). Of the 102 (39.2%) patients who met criteria for melancholic depression and the 158 (60.7%) who did not, there were no significant differences in age, gender, or rates of personality disorder diagnoses. We observed no significant difference in rates of individual personality disorder clusters between melancholic and nonmelancholic depressed patients. Our findings of comparable rates of comorbid personality disorders between melancholic and nonmelancholic depression are consistent with the decision made by the DSM-IV task force to drop the DSM-III-R melancholic feature criterion of "no significant personality disturbance before first major depressive episode" as they challenge the usefulness of trying to establish such absence of premorbid personality features in acutely depressed patients.

AB - This study assessed whether the rates of comorbid personality disorders differed between DSM-IV melancholic and nonmelancholic major depressive disorder. We evaluated 260 consecutive depressed outpatients (140 women [53.8%]; mean age, 39.01 ± 10.4 years) with DSM-III-R major depressive disorder (MDD). MDD was diagnosed with the use of the Structured Clinical Interview for DSM-III-R-Patient Edition (SCID-P); enrolled patients were required to have a score ≥ 16 on the 17-item Hamilton Rating Scale for Depression (HAM-D-17). The presence of the melancholic subtype of major depression was determined with the use of a DSM-IV checklist, while the presence of personality disorders was assessed using the Structured Clinical Interview for DSM-III-R-Personality Disorders (SCID-II). Of the 102 (39.2%) patients who met criteria for melancholic depression and the 158 (60.7%) who did not, there were no significant differences in age, gender, or rates of personality disorder diagnoses. We observed no significant difference in rates of individual personality disorder clusters between melancholic and nonmelancholic depressed patients. Our findings of comparable rates of comorbid personality disorders between melancholic and nonmelancholic depression are consistent with the decision made by the DSM-IV task force to drop the DSM-III-R melancholic feature criterion of "no significant personality disturbance before first major depressive episode" as they challenge the usefulness of trying to establish such absence of premorbid personality features in acutely depressed patients.

UR - http://www.scopus.com/inward/record.url?scp=0036733685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036733685&partnerID=8YFLogxK

U2 - 10.1053/comp.2002.34631

DO - 10.1053/comp.2002.34631

M3 - Article

C2 - 12216007

AN - SCOPUS:0036733685

VL - 43

SP - 331

EP - 335

JO - Comprehensive Psychiatry

JF - Comprehensive Psychiatry

SN - 0010-440X

IS - 5

ER -