Meeting the physical activity guidelines and survival after breast cancer: Findings from the after breast cancer pooling project

Jeannette M. Beasley, Marilyn L. Kwan, Wendy Y. Chen, Erin K. Weltzien, Candyce H. Kroenke, Wei Lu, Sarah J. Nechuta, Lisa Cadmus-Bertram, Ruth E. Patterson, Barbara Sternfeld, Xiao Ou Shu, John P. Pierce, Bette J. Caan

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The 2008 Physical Activity (PA) Guidelines recommend engaging in at least 2.5 h (10 MET-hours/week) of moderate intensity PA per week (defined as 4 METs) to reduce risk of morbidity and mortality. This analysis was conducted to investigate whether this recommendation can be extended to breast cancer survivors. Data from four studies of breast cancer survivors measuring recreational PA from semi-quantitative questionnaires a median of 23 months post-diagnosis (interquartile range 18-32 months) were pooled in the After Breast Cancer Pooling Project (n = 13,302). Delayed entry Cox proportional hazards models were applied in data analysis with adjustment for age, post-diagnosis body mass index, race/ethnicity, menopausal status, TNM stage, cancer treatment, and smoking history. Engaging in at least 10 MET-hours/week of PA was associated with a 27% reduction in all-cause mortality (n = 1,468 events, Hazard Ratio (HR) = 0.73, 95% CI, 0.66-0.82) and a 25% reduction in breast cancer mortality (n = 971 events, HR = 0.75, 95% CI 0.65-0.85) compared with women who did not meet the PA Guidelines (<10 MET-hours/week). Risk of breast cancer recurrence (n = 1,421 events) was not associated with meeting the PA Guidelines (HR = 0.96, 95% CI, 0.86-1.06). These data suggest that adhering to the PA guidelines may be an important intervention target for reducing mortality among breast cancer survivors.

Original languageEnglish (US)
Pages (from-to)637-643
Number of pages7
JournalBreast Cancer Research and Treatment
Volume131
Issue number2
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Guidelines
Exercise
Breast Neoplasms
Survival
Survivors
Mortality
Proportional Hazards Models
Body Mass Index
Smoking
History
Morbidity
Recurrence
Neoplasms
Therapeutics

Keywords

  • Breast cancer survival
  • Epidemiology
  • Mortality
  • Physical activity guidelines

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Meeting the physical activity guidelines and survival after breast cancer : Findings from the after breast cancer pooling project. / Beasley, Jeannette M.; Kwan, Marilyn L.; Chen, Wendy Y.; Weltzien, Erin K.; Kroenke, Candyce H.; Lu, Wei; Nechuta, Sarah J.; Cadmus-Bertram, Lisa; Patterson, Ruth E.; Sternfeld, Barbara; Shu, Xiao Ou; Pierce, John P.; Caan, Bette J.

In: Breast Cancer Research and Treatment, Vol. 131, No. 2, 01.2012, p. 637-643.

Research output: Contribution to journalArticle

Beasley, JM, Kwan, ML, Chen, WY, Weltzien, EK, Kroenke, CH, Lu, W, Nechuta, SJ, Cadmus-Bertram, L, Patterson, RE, Sternfeld, B, Shu, XO, Pierce, JP & Caan, BJ 2012, 'Meeting the physical activity guidelines and survival after breast cancer: Findings from the after breast cancer pooling project', Breast Cancer Research and Treatment, vol. 131, no. 2, pp. 637-643. https://doi.org/10.1007/s10549-011-1770-1
Beasley, Jeannette M. ; Kwan, Marilyn L. ; Chen, Wendy Y. ; Weltzien, Erin K. ; Kroenke, Candyce H. ; Lu, Wei ; Nechuta, Sarah J. ; Cadmus-Bertram, Lisa ; Patterson, Ruth E. ; Sternfeld, Barbara ; Shu, Xiao Ou ; Pierce, John P. ; Caan, Bette J. / Meeting the physical activity guidelines and survival after breast cancer : Findings from the after breast cancer pooling project. In: Breast Cancer Research and Treatment. 2012 ; Vol. 131, No. 2. pp. 637-643.
@article{fad26a0f643a471e8bb0ba8659c0e143,
title = "Meeting the physical activity guidelines and survival after breast cancer: Findings from the after breast cancer pooling project",
abstract = "The 2008 Physical Activity (PA) Guidelines recommend engaging in at least 2.5 h (10 MET-hours/week) of moderate intensity PA per week (defined as 4 METs) to reduce risk of morbidity and mortality. This analysis was conducted to investigate whether this recommendation can be extended to breast cancer survivors. Data from four studies of breast cancer survivors measuring recreational PA from semi-quantitative questionnaires a median of 23 months post-diagnosis (interquartile range 18-32 months) were pooled in the After Breast Cancer Pooling Project (n = 13,302). Delayed entry Cox proportional hazards models were applied in data analysis with adjustment for age, post-diagnosis body mass index, race/ethnicity, menopausal status, TNM stage, cancer treatment, and smoking history. Engaging in at least 10 MET-hours/week of PA was associated with a 27{\%} reduction in all-cause mortality (n = 1,468 events, Hazard Ratio (HR) = 0.73, 95{\%} CI, 0.66-0.82) and a 25{\%} reduction in breast cancer mortality (n = 971 events, HR = 0.75, 95{\%} CI 0.65-0.85) compared with women who did not meet the PA Guidelines (<10 MET-hours/week). Risk of breast cancer recurrence (n = 1,421 events) was not associated with meeting the PA Guidelines (HR = 0.96, 95{\%} CI, 0.86-1.06). These data suggest that adhering to the PA guidelines may be an important intervention target for reducing mortality among breast cancer survivors.",
keywords = "Breast cancer survival, Epidemiology, Mortality, Physical activity guidelines",
author = "Beasley, {Jeannette M.} and Kwan, {Marilyn L.} and Chen, {Wendy Y.} and Weltzien, {Erin K.} and Kroenke, {Candyce H.} and Wei Lu and Nechuta, {Sarah J.} and Lisa Cadmus-Bertram and Patterson, {Ruth E.} and Barbara Sternfeld and Shu, {Xiao Ou} and Pierce, {John P.} and Caan, {Bette J.}",
year = "2012",
month = "1",
doi = "10.1007/s10549-011-1770-1",
language = "English (US)",
volume = "131",
pages = "637--643",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Meeting the physical activity guidelines and survival after breast cancer

T2 - Findings from the after breast cancer pooling project

AU - Beasley, Jeannette M.

AU - Kwan, Marilyn L.

AU - Chen, Wendy Y.

AU - Weltzien, Erin K.

AU - Kroenke, Candyce H.

AU - Lu, Wei

AU - Nechuta, Sarah J.

AU - Cadmus-Bertram, Lisa

AU - Patterson, Ruth E.

AU - Sternfeld, Barbara

AU - Shu, Xiao Ou

AU - Pierce, John P.

AU - Caan, Bette J.

PY - 2012/1

Y1 - 2012/1

N2 - The 2008 Physical Activity (PA) Guidelines recommend engaging in at least 2.5 h (10 MET-hours/week) of moderate intensity PA per week (defined as 4 METs) to reduce risk of morbidity and mortality. This analysis was conducted to investigate whether this recommendation can be extended to breast cancer survivors. Data from four studies of breast cancer survivors measuring recreational PA from semi-quantitative questionnaires a median of 23 months post-diagnosis (interquartile range 18-32 months) were pooled in the After Breast Cancer Pooling Project (n = 13,302). Delayed entry Cox proportional hazards models were applied in data analysis with adjustment for age, post-diagnosis body mass index, race/ethnicity, menopausal status, TNM stage, cancer treatment, and smoking history. Engaging in at least 10 MET-hours/week of PA was associated with a 27% reduction in all-cause mortality (n = 1,468 events, Hazard Ratio (HR) = 0.73, 95% CI, 0.66-0.82) and a 25% reduction in breast cancer mortality (n = 971 events, HR = 0.75, 95% CI 0.65-0.85) compared with women who did not meet the PA Guidelines (<10 MET-hours/week). Risk of breast cancer recurrence (n = 1,421 events) was not associated with meeting the PA Guidelines (HR = 0.96, 95% CI, 0.86-1.06). These data suggest that adhering to the PA guidelines may be an important intervention target for reducing mortality among breast cancer survivors.

AB - The 2008 Physical Activity (PA) Guidelines recommend engaging in at least 2.5 h (10 MET-hours/week) of moderate intensity PA per week (defined as 4 METs) to reduce risk of morbidity and mortality. This analysis was conducted to investigate whether this recommendation can be extended to breast cancer survivors. Data from four studies of breast cancer survivors measuring recreational PA from semi-quantitative questionnaires a median of 23 months post-diagnosis (interquartile range 18-32 months) were pooled in the After Breast Cancer Pooling Project (n = 13,302). Delayed entry Cox proportional hazards models were applied in data analysis with adjustment for age, post-diagnosis body mass index, race/ethnicity, menopausal status, TNM stage, cancer treatment, and smoking history. Engaging in at least 10 MET-hours/week of PA was associated with a 27% reduction in all-cause mortality (n = 1,468 events, Hazard Ratio (HR) = 0.73, 95% CI, 0.66-0.82) and a 25% reduction in breast cancer mortality (n = 971 events, HR = 0.75, 95% CI 0.65-0.85) compared with women who did not meet the PA Guidelines (<10 MET-hours/week). Risk of breast cancer recurrence (n = 1,421 events) was not associated with meeting the PA Guidelines (HR = 0.96, 95% CI, 0.86-1.06). These data suggest that adhering to the PA guidelines may be an important intervention target for reducing mortality among breast cancer survivors.

KW - Breast cancer survival

KW - Epidemiology

KW - Mortality

KW - Physical activity guidelines

UR - http://www.scopus.com/inward/record.url?scp=84856210573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84856210573&partnerID=8YFLogxK

U2 - 10.1007/s10549-011-1770-1

DO - 10.1007/s10549-011-1770-1

M3 - Article

C2 - 21935600

AN - SCOPUS:84856210573

VL - 131

SP - 637

EP - 643

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 2

ER -