Mediators Secreted by Myeloid Cells May Protect and Repair the Infarcted Myocardium

Research output: Contribution to journalArticle

Abstract

In the infarcted myocardium, cardiomyocyte necrosis activates inflammatory cascades resulting in recruitment of myeloid cells that have been suggested to extend ischemic injury, but also clear the infarct from dead cells and matrix debris, and stimulate the reparative process. A growing body of evidence suggests that subsets of myeloid cells may exert protective actions on the infarcted myocardium. A recently published study in Nature Medicine, identified myeloid-derived growth factor as an antiapoptotic and angiogenic mediator that is secreted by a subset of macrophages and may protect the infarcted heart from adverse remodeling.

Original languageEnglish (US)
Pages (from-to)10-12
Number of pages3
JournalCirculation Research
Volume117
Issue number1
DOIs
StatePublished - Jun 19 2015

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Myeloid Cells
Myocardium
Cardiac Myocytes
Intercellular Signaling Peptides and Proteins
Necrosis
Macrophages
Medicine
Wounds and Injuries

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Mediators Secreted by Myeloid Cells May Protect and Repair the Infarcted Myocardium. / Shinde, Arti V.; Frangogiannis, Nikolaos G.

In: Circulation Research, Vol. 117, No. 1, 19.06.2015, p. 10-12.

Research output: Contribution to journalArticle

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