Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP

Marc G. Weisskopf, Pablo E. Castillo, Robert A. Zalutsky, Roger A. Nicoll

Research output: Contribution to journalArticle

441 Citations (Scopus)

Abstract

Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-aspartate receptor activation. Previous results suggest that the site for both the induction and expression of this form of LTP is presynaptic. Experimental elevation of cyclic adenosine 3',5'-monophosphate (cAMP) both mimics and interferes with tetanus-induced mossy fiber LTP, and blockers of the cAMP cascade block mossy fiber LTP. It is proposed that calcium entry into the presynaptic terminal may activate Ca2+-calmodulin-sensitive adenylyl cyclase I which, through protein kinase A, causes a persistent enhancement of evoked glutamate release.

Original languageEnglish (US)
Pages (from-to)1878-1882
Number of pages5
JournalScience
Volume265
Issue number5180
StatePublished - Sep 23 1994
Externally publishedYes

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Hippocampal Mossy Fibers
Long-Term Potentiation
Cyclic AMP
Pyramidal Cells
Presynaptic Terminals
Tetanus
Calmodulin
Cyclic AMP-Dependent Protein Kinases
N-Methyl-D-Aspartate Receptors
Glutamic Acid
Calcium

ASJC Scopus subject areas

  • General

Cite this

Weisskopf, M. G., Castillo, P. E., Zalutsky, R. A., & Nicoll, R. A. (1994). Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP. Science, 265(5180), 1878-1882.

Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP. / Weisskopf, Marc G.; Castillo, Pablo E.; Zalutsky, Robert A.; Nicoll, Roger A.

In: Science, Vol. 265, No. 5180, 23.09.1994, p. 1878-1882.

Research output: Contribution to journalArticle

Weisskopf, MG, Castillo, PE, Zalutsky, RA & Nicoll, RA 1994, 'Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP', Science, vol. 265, no. 5180, pp. 1878-1882.
Weisskopf MG, Castillo PE, Zalutsky RA, Nicoll RA. Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP. Science. 1994 Sep 23;265(5180):1878-1882.
Weisskopf, Marc G. ; Castillo, Pablo E. ; Zalutsky, Robert A. ; Nicoll, Roger A. / Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP. In: Science. 1994 ; Vol. 265, No. 5180. pp. 1878-1882.
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