TY - JOUR
T1 - Mediating lipid biosynthesis
T2 - Implications for cardiovascular disease
AU - Xiaoli,
AU - Yang, Fajun
N1 - Funding Information:
This work is supported by National Institutes of Health ( DK093623 ), American Diabetes Association ( 7-11-BS-173 ), and Einstein Diabetes Research Center ( P60-DK020541 ). The authors would like to thank Dr. Jeffery Pessin, Dr. Jun-yuan Ji, and members of the Yang laboratory. We apologize to our colleagues for being unable to cite all appropriate references owing to space limitations.
PY - 2013/10
Y1 - 2013/10
N2 - Dysregulation of lipid homeostasis is a risk factor for cardiovascular disease (CVD). Thus, understanding the molecular mechanisms of maintaining lipid homeostasis may aid the discovery of novel targets for treating CVD. MED15 and cyclin-dependent kinase-8 (CDK8) are subunits of the Mediator complex, which contains multiple proteins and functions as a transcriptional cofactor. Mediator can positively or negatively regulate gene expression, depending on the contexts and its associated transcription factors. Recent studies revealed a critical role of MED15 and CDK8 in regulating sterol regulatory element-binding protein (SREBP) transcription factors, which are master activators for genes that are responsible for lipid biosynthesis. Here, we review the function of MED15 and CDK8 in regulating lipid homeostasis and discuss the implications for CVD.
AB - Dysregulation of lipid homeostasis is a risk factor for cardiovascular disease (CVD). Thus, understanding the molecular mechanisms of maintaining lipid homeostasis may aid the discovery of novel targets for treating CVD. MED15 and cyclin-dependent kinase-8 (CDK8) are subunits of the Mediator complex, which contains multiple proteins and functions as a transcriptional cofactor. Mediator can positively or negatively regulate gene expression, depending on the contexts and its associated transcription factors. Recent studies revealed a critical role of MED15 and CDK8 in regulating sterol regulatory element-binding protein (SREBP) transcription factors, which are master activators for genes that are responsible for lipid biosynthesis. Here, we review the function of MED15 and CDK8 in regulating lipid homeostasis and discuss the implications for CVD.
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U2 - 10.1016/j.tcm.2013.03.002
DO - 10.1016/j.tcm.2013.03.002
M3 - Review article
C2 - 23562092
AN - SCOPUS:84883803845
SN - 1050-1738
VL - 23
SP - 269
EP - 273
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 7
ER -
