Mediastinal kaposiform hemangioendothelioma and kasabach-merritt phenomenon in an infant: Treatment with interferon

Kip R. Hartman, Joel T. Moncur, Caterina P. Minniti, Kevin M. Creamer

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A 2-week-old infant developed respiratory failure due to a mediastinal Kaposiform hemangioendothelioma that was complicated by thrombocytopenia and consumptive coagulopathy. Initial surgery was unsuccessful at removing the tumorous infiltration of mediastinal structures. Multiple transfusions with fresh frozen plasma, platelets, and red blood cells were needed for the consumptive coagulopathy, and ventilatory support was required for 5 months. Therapy for the tumor included methylprednisolone, aminocaproic acid, and vincristine, but a sustained response was achieved only after the initiation of alpha interferon. The patient was monitored closely and did not develop neurologic toxicity. This case demonstrates that interferon can be used to treat infants with Kaposiform hemangioendothelioma in life-threatening situations that do not respond to other forms of treatment

Original languageEnglish (US)
Pages (from-to)690-692
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume31
Issue number9
DOIs
StatePublished - Sep 2009
Externally publishedYes

Fingerprint

Kasabach-Merritt Syndrome
Interferons
Aminocaproic Acid
Methylprednisolone
Vincristine
Interferon-alpha
Respiratory Insufficiency
Thrombocytopenia
Nervous System
Blood Platelets
Erythrocytes
Therapeutics
Neoplasms
Kaposiform Hemangioendothelioma

Keywords

  • Interferon therapy
  • Kaposiform hemangioendothelioma
  • Kasabach-Merritt phenomenon
  • Steroid therapy
  • Vincristine therapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Mediastinal kaposiform hemangioendothelioma and kasabach-merritt phenomenon in an infant : Treatment with interferon. / Hartman, Kip R.; Moncur, Joel T.; Minniti, Caterina P.; Creamer, Kevin M.

In: Journal of Pediatric Hematology/Oncology, Vol. 31, No. 9, 09.2009, p. 690-692.

Research output: Contribution to journalArticle

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