MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of rett syndrome

Megumi Adachi, Anita E. Autry, Herb E. Covington, Lisa M. Monteggia

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder that results from loss of function mutations in the methyl-CpG binding protein 2 (MECP2) gene. Using viral-mediated basolateral amygdala (BLA)-specific deletion of Mecp2 in mice, we show that intact Mecp2 function is required for normal anxiety behavior as well as some types of learning and memory. To examine whether these behavioral deficits are the result of impaired transcriptional repression, because Mecp2 is believed to act as a transcriptional repressor in complex with histone deacetylases (HDACs), we infused a HDAC inhibitor chronically into the BLA of wild-type mice. We found that HDAC inhibition produces behavioral deficits similar to those observed after the deletion of Mecp2 in the BLA. These results suggest a key role for Mecp2 as a transcriptional repressor in the BLA in mediating behavioral features of RTT.

Original languageEnglish (US)
Pages (from-to)4218-4227
Number of pages10
JournalJournal of Neuroscience
Volume29
Issue number13
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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