Meconium and transitional stools may cause interference with near-infrared spectroscopy measurements of intestinal oxygen saturation in preterm infants

Alecia Thompson, Paul Benni, Sara Seyhan, Richard Ehrenkranz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

In a pilot study, we found that the NIRS measurements were highly variable and dramatically decreased or disappeared sporadically while monitoring gastro-intestinal (GI) StO2 on preterm neonates. We hypothesized that the light absorption characteristics of different neonatal and infant stool types may be interfering with NIRS GI measurements. Methods: Meconium, transitional, and mature stool samples collected from preterm neonates and older infants (ranging from a few days to weeks in age) were analyzed by a bench-top spectrometer to measure light absorbance in the near infrared range (650-950 nm). Results: Some meconium and transitional stool samples were noted to have a more marked increase in light absorbance as wavelength decreases towards 650 nm, when compared to more mature stools. When compared to the light absorbance spectra of deoxy-hemoglobin (Hb) and oxy-hemoglobin (HbO2), there is a high potential that Hb and HbO2 may be erroneously calculated, resulting in falsely low GI StO2. Discussion: Meconium and green colored transitional stools demonstrate a light absorbance spectra that may interfere with NIRS GI measurements, possibly due to their higher biliverdin content, which exhibits a broad spectral absorption peak at 660 nm. Caution is warranted in interpreting GI StO2 NIRS results in neonates still passing meconium and transitional stools until NIRS-based tissue oximeters to measure GI StO2 can compensate for the presence of these stool types.

Original languageEnglish (US)
Title of host publicationOxygen Transport to Tissue XXXIV
EditorsWilliam J. Welch, Duane F. Bruley, Fredrik Palm, Harrison Harrison
Pages287-292
Number of pages6
DOIs
Publication statusPublished - Jan 1 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume765
ISSN (Print)0065-2598

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Keywords

  • Intestine
  • Meconium
  • Near-infrared spectroscopy
  • StO
  • Stools

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Thompson, A., Benni, P., Seyhan, S., & Ehrenkranz, R. (2013). Meconium and transitional stools may cause interference with near-infrared spectroscopy measurements of intestinal oxygen saturation in preterm infants. In W. J. Welch, D. F. Bruley, F. Palm, & H. Harrison (Eds.), Oxygen Transport to Tissue XXXIV (pp. 287-292). (Advances in Experimental Medicine and Biology; Vol. 765). https://doi.org/10.1007/978-1-4614-4989-8-40