Mechanotransduction and cartilage integrity

Daniel J. Leong, John A. Hardin, Neil J. Cobelli, Hui (Herb) Sun

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Osteoarthritis (OA) is characterized by the breakdown of articular cartilage that is mediated in part by increased production of matrix metalloproteinases (MMPs) and aggrecanases (ADAMTS), enzymes that degrade components of the cartilage extracellular matrix. Efforts to design synthetic inhibitors of MMPs/ADAMTS have only led to limited clinical success. In addition to pharmacologic therapies, physiologic joint loading is widely recommended as a nonpharmacologic approach to improve joint function in osteoarthritis. Clinical trials report that moderate levels of exercise exert beneficial effects, such as improvements in pain and physical function. Experimental studies demonstrate that mechanical loading mitigates joint destruction through the downregulation of MMPs/ADAMTS. However, the molecular mechanisms underlying these effects of physiologic loading on arthritic joints are not well understood. We review here the recent progress on mechanotransduction in articular joints, highlighting the mediators and pathways in the maintenance of cartilage integrity, especially in the prevention of cartilage degradation in OA.

Original languageEnglish (US)
Pages (from-to)32-37
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1240
Issue number1
DOIs
StatePublished - Dec 2011

Fingerprint

Cartilage
Joints
Matrix Metalloproteinases
Osteoarthritis
Matrix Metalloproteinase Inhibitors
Articular Cartilage
Degradation
Arthritis
Extracellular Matrix
Integrity
Enzymes
Down-Regulation
Maintenance
Clinical Trials
Pain

Keywords

  • Cartilage degradation
  • Exercise
  • Mechanical loading
  • Osteoarthritis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Mechanotransduction and cartilage integrity. / Leong, Daniel J.; Hardin, John A.; Cobelli, Neil J.; Sun, Hui (Herb).

In: Annals of the New York Academy of Sciences, Vol. 1240, No. 1, 12.2011, p. 32-37.

Research output: Contribution to journalArticle

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