TY - CHAP
T1 - Mechanistic role of kinases in the regulation of mitochondrial fitness
AU - Sorriento, Daniela
AU - Gambardella, Jessica
AU - Fiordelisi, Antonella
AU - Trimarco, Bruno
AU - Ciccarelli, Michele
AU - Iaccarino, Guido
AU - Santulli, Gaetano
N1 - Publisher Copyright:
© 2017, Springer International Publishing AG.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Mounting evidence indicates that mitochondria contain multiple phosphorylation substrates and that protein kinases translocate into mitochondria, suggesting that protein phosphorylation in this organelle could be fundamental for the regulation of its own function. Here we examine the mechanistic role of cellular kinases in the fine regulation of key mitochondrial activities, including mitochondrial quality control, fission/fusion processes, metabolism, and mitophagy.
AB - Mounting evidence indicates that mitochondria contain multiple phosphorylation substrates and that protein kinases translocate into mitochondria, suggesting that protein phosphorylation in this organelle could be fundamental for the regulation of its own function. Here we examine the mechanistic role of cellular kinases in the fine regulation of key mitochondrial activities, including mitochondrial quality control, fission/fusion processes, metabolism, and mitophagy.
UR - http://www.scopus.com/inward/record.url?scp=85019969280&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019969280&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-55330-6_26
DO - 10.1007/978-3-319-55330-6_26
M3 - Chapter
C2 - 28551804
AN - SCOPUS:85019969280
T3 - Advances in Experimental Medicine and Biology
SP - 521
EP - 528
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -