Mechanisms Underlying Arrhythmogenesis Associated with Heart Failure

David N. Edwards, Andreas S. Barth, Gordon F. Tomaselli

Research output: Contribution to journalReview article

Abstract

The hallmark of electrophysiologic remodeling in heart failure is arrhythmogenic prolongation of the action potential. Downregulation of repolarizing K+ currents and bioenergetic pathways are hallmarks of electrophysiological remodeling. Ion transport and mitochondrial bioenergetic transcripts are tightly co-regulated, with a predicted increase in electrical instability in the failing myocardium. Cardiac resynchronization therapy (CRT) significantly shortens the action potential particularly in myocytes isolated from the lateral wall of the left ventricle during dyssynchronous contraction. This partial normalization of the electrical phenotype may provide an explanation for the reduced risk for arrhythmias and better prognosis after CRT.

Original languageEnglish (US)
Pages (from-to)57-68
Number of pages12
JournalCardiac Electrophysiology Clinics
Volume3
Issue number1
DOIs
StatePublished - Mar 1 2011
Externally publishedYes

Fingerprint

Cardiac Resynchronization Therapy
Energy Metabolism
Action Potentials
Heart Failure
Ion Transport
Muscle Cells
Heart Ventricles
Cardiac Arrhythmias
Myocardium
Down-Regulation
Phenotype

Keywords

  • Action potential
  • CRT
  • Gene expression
  • Heart failure
  • Ion channels
  • Remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Mechanisms Underlying Arrhythmogenesis Associated with Heart Failure. / Edwards, David N.; Barth, Andreas S.; Tomaselli, Gordon F.

In: Cardiac Electrophysiology Clinics, Vol. 3, No. 1, 01.03.2011, p. 57-68.

Research output: Contribution to journalReview article

@article{ae3134eaf9ac4993b04306e0780b4782,
title = "Mechanisms Underlying Arrhythmogenesis Associated with Heart Failure",
abstract = "The hallmark of electrophysiologic remodeling in heart failure is arrhythmogenic prolongation of the action potential. Downregulation of repolarizing K+ currents and bioenergetic pathways are hallmarks of electrophysiological remodeling. Ion transport and mitochondrial bioenergetic transcripts are tightly co-regulated, with a predicted increase in electrical instability in the failing myocardium. Cardiac resynchronization therapy (CRT) significantly shortens the action potential particularly in myocytes isolated from the lateral wall of the left ventricle during dyssynchronous contraction. This partial normalization of the electrical phenotype may provide an explanation for the reduced risk for arrhythmias and better prognosis after CRT.",
keywords = "Action potential, CRT, Gene expression, Heart failure, Ion channels, Remodeling",
author = "Edwards, {David N.} and Barth, {Andreas S.} and Tomaselli, {Gordon F.}",
year = "2011",
month = "3",
day = "1",
doi = "10.1016/j.ccep.2010.10.009",
language = "English (US)",
volume = "3",
pages = "57--68",
journal = "Cardiac Electrophysiology Clinics",
issn = "1877-9182",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Mechanisms Underlying Arrhythmogenesis Associated with Heart Failure

AU - Edwards, David N.

AU - Barth, Andreas S.

AU - Tomaselli, Gordon F.

PY - 2011/3/1

Y1 - 2011/3/1

N2 - The hallmark of electrophysiologic remodeling in heart failure is arrhythmogenic prolongation of the action potential. Downregulation of repolarizing K+ currents and bioenergetic pathways are hallmarks of electrophysiological remodeling. Ion transport and mitochondrial bioenergetic transcripts are tightly co-regulated, with a predicted increase in electrical instability in the failing myocardium. Cardiac resynchronization therapy (CRT) significantly shortens the action potential particularly in myocytes isolated from the lateral wall of the left ventricle during dyssynchronous contraction. This partial normalization of the electrical phenotype may provide an explanation for the reduced risk for arrhythmias and better prognosis after CRT.

AB - The hallmark of electrophysiologic remodeling in heart failure is arrhythmogenic prolongation of the action potential. Downregulation of repolarizing K+ currents and bioenergetic pathways are hallmarks of electrophysiological remodeling. Ion transport and mitochondrial bioenergetic transcripts are tightly co-regulated, with a predicted increase in electrical instability in the failing myocardium. Cardiac resynchronization therapy (CRT) significantly shortens the action potential particularly in myocytes isolated from the lateral wall of the left ventricle during dyssynchronous contraction. This partial normalization of the electrical phenotype may provide an explanation for the reduced risk for arrhythmias and better prognosis after CRT.

KW - Action potential

KW - CRT

KW - Gene expression

KW - Heart failure

KW - Ion channels

KW - Remodeling

UR - http://www.scopus.com/inward/record.url?scp=78751629508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78751629508&partnerID=8YFLogxK

U2 - 10.1016/j.ccep.2010.10.009

DO - 10.1016/j.ccep.2010.10.009

M3 - Review article

VL - 3

SP - 57

EP - 68

JO - Cardiac Electrophysiology Clinics

JF - Cardiac Electrophysiology Clinics

SN - 1877-9182

IS - 1

ER -