Mechanisms of virus membrane fusion proteins

Margaret Kielian

doi:10.1146/annurev-virology-031413-085521

Mechanisms of virus membrane fusion proteins

Margaret Kielian

Cell Biology

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Abstract

Enveloped viruses infect host cells by a membrane fusion reaction that takes place at the cell surface or in intracellular compartments following virus uptake. Fusion is mediated by the membrane interactions and conformational changes of specialized virus envelope proteins termed membrane fusion proteins. This article discusses the structures and refolding reactions of specific fusion proteins and the methods for their study and highlights outstanding questions in the field.

Original language	English (US)
Pages (from-to)	171-189
Number of pages	19
Journal	Annual Review of Virology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1146/annurev-virology-031413-085521
State	Published - Sep 29 2014

Keywords

Alphavirus
Flavivirus
Influenza hemagglutinin
Influenza virus
Pestivirus
Rhabdovirus
Virus entry

ASJC Scopus subject areas

Virology

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10.1146/annurev-virology-031413-085521

Cite this

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AB - Enveloped viruses infect host cells by a membrane fusion reaction that takes place at the cell surface or in intracellular compartments following virus uptake. Fusion is mediated by the membrane interactions and conformational changes of specialized virus envelope proteins termed membrane fusion proteins. This article discusses the structures and refolding reactions of specific fusion proteins and the methods for their study and highlights outstanding questions in the field.

KW - Alphavirus

KW - Flavivirus

KW - Influenza hemagglutinin

KW - Influenza virus

KW - Pestivirus

KW - Rhabdovirus

KW - Virus entry

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Mechanisms of virus membrane fusion proteins

Abstract

Keywords

ASJC Scopus subject areas

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