Mechanisms of virus membrane fusion proteins

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Enveloped viruses infect host cells by a membrane fusion reaction that takes place at the cell surface or in intracellular compartments following virus uptake. Fusion is mediated by the membrane interactions and conformational changes of specialized virus envelope proteins termed membrane fusion proteins. This article discusses the structures and refolding reactions of specific fusion proteins and the methods for their study and highlights outstanding questions in the field.

Original languageEnglish (US)
Pages (from-to)171-189
Number of pages19
JournalAnnual Review of Virology
Volume1
Issue number1
DOIs
StatePublished - Sep 29 2014

Fingerprint

Membrane Fusion Proteins
Viral Fusion Proteins
Virus Internalization
Viral Envelope Proteins
Viruses
Membrane Fusion
Cell Membrane
Membranes
Proteins

Keywords

  • Alphavirus
  • Flavivirus
  • Influenza hemagglutinin
  • Influenza virus
  • Pestivirus
  • Rhabdovirus
  • Virus entry

ASJC Scopus subject areas

  • Virology

Cite this

Mechanisms of virus membrane fusion proteins. / Kielian, Margaret.

In: Annual Review of Virology, Vol. 1, No. 1, 29.09.2014, p. 171-189.

Research output: Contribution to journalArticle

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