Mechanisms of self-inactivation in anergic T cells

Rut Valdor, Fernando Macian

Research output: Contribution to journalReview article

Abstract

Self-reactive T cells that escape negative selection in the thymus must be inactivated or eliminated in the periphery. In response to a partial or suboptimal stimulation, T cells become anergic and unable to proliferate and express cytokines in response subsequent re-encounters with antigen. Calcium signaling plays a central role in the induction of anergy, causing the activation of a calcium/calcineurin/NFAT-dependent cell-intrinsic program of self-inactivation. This review will focus on our current knowledge on the mechanisms that regulate the expression of an anergy-specific program of gene expression in T cells, and how the proteins encoded by those genes impose a state of functional unresponsiveness by targeting and modulating the activity of crucial events required for the activation of T cells, which include downregulation of TCR signaling and inhibition of cytokine transcription.

Original languageEnglish (US)
Pages (from-to)20-33
Number of pages14
JournalInmunologia
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • NFAT
  • Regulatory T cell
  • T cell anergy
  • Tolerance

ASJC Scopus subject areas

  • Immunology

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