Mechanisms of self-inactivation in anergic T cells

Research output: Contribution to journalArticle

Abstract

Self-reactive T cells that escape negative selection in the thymus must be inactivated or eliminated in the periphery. In response to a partial or suboptimal stimulation, T cells become anergic and unable to proliferate and express cytokines in response subsequent re-encounters with antigen. Calcium signaling plays a central role in the induction of anergy, causing the activation of a calcium/calcineurin/NFAT-dependent cell-intrinsic program of self-inactivation. This review will focus on our current knowledge on the mechanisms that regulate the expression of an anergy-specific program of gene expression in T cells, and how the proteins encoded by those genes impose a state of functional unresponsiveness by targeting and modulating the activity of crucial events required for the activation of T cells, which include downregulation of TCR signaling and inhibition of cytokine transcription.

Original languageEnglish (US)
Pages (from-to)20-33
Number of pages14
JournalInmunologia
Volume29
Issue number1
StatePublished - Jan 2010

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T-Lymphocytes
Cytokines
Calcium Signaling
Calcineurin
Thymus Gland
Down-Regulation
Calcium
Gene Expression
Antigens
Genes
Proteins

Keywords

  • NFAT
  • Regulatory T cell
  • T cell anergy
  • Tolerance

ASJC Scopus subject areas

  • Immunology

Cite this

Mechanisms of self-inactivation in anergic T cells. / Valdor, Rut; Macian-Juan, Fernando.

In: Inmunologia, Vol. 29, No. 1, 01.2010, p. 20-33.

Research output: Contribution to journalArticle

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