Abstract
Self-reactive T cells that escape negative selection in the thymus must be inactivated or eliminated in the periphery. In response to a partial or suboptimal stimulation, T cells become anergic and unable to proliferate and express cytokines in response subsequent re-encounters with antigen. Calcium signaling plays a central role in the induction of anergy, causing the activation of a calcium/calcineurin/NFAT-dependent cell-intrinsic program of self-inactivation. This review will focus on our current knowledge on the mechanisms that regulate the expression of an anergy-specific program of gene expression in T cells, and how the proteins encoded by those genes impose a state of functional unresponsiveness by targeting and modulating the activity of crucial events required for the activation of T cells, which include downregulation of TCR signaling and inhibition of cytokine transcription.
Original language | English (US) |
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Pages (from-to) | 20-33 |
Number of pages | 14 |
Journal | Inmunologia |
Volume | 29 |
Issue number | 1 |
DOIs | |
State | Published - 2010 |
Keywords
- NFAT
- Regulatory T cell
- T cell anergy
- Tolerance
ASJC Scopus subject areas
- Immunology