Mechanisms of premature vascular aging in children with hutchinson-gilford progeria syndrome

Marie Gerhard-Herman, Leslie B. Smoot, Nicole Wake, Mark W. Kieran, Monica E. Kleinman, David T. Miller, Armin Schwartzman, Anita Giobbie-Hurder, Donna Neuberg, Leslie B. Gordon

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Hutchinson-Gilford progeria syndrome is a rare, segmental premature aging syndrome of accelerated atherosclerosis and early death from myocardial infarction or stroke. This study sought to establish comprehensive characterization of the fatal vasculopathy in Hutchinson-Gilford progeria syndrome and its relevance to normal aging. We performed cardiovascular assessments at a single clinical site on the largest prospectively studied cohort to date. Carotid-femoral pulse wave velocity was dramatically elevated (mean: 13.00±3.83 m/s). Carotid duplex ultrasound echobrightness, assessed in predefined tissue sites as a measure of arterial wall density, was significantly greater than age-and sex-matched controls in the intima-media (P<0.02), near adventitia (P<0.003), and deep adventitia (P<0.01), as was internal carotid artery mean flow velocity (P<0.0001). Ankle-brachial indices were abnormal in 78% of patients. Effective disease treatments may be heralded by normalizing trends of these noninvasive cardiovascular measures. The data demonstrate that, along with peripheral vascular occlusive disease, accelerated vascular stiffening is an early and pervasive mechanism of vascular disease in Hutchinson-Gilford progeria syndrome. There is considerable overlap with cardiovascular changes of normal aging, which reinforces the view that defining mechanisms of cardiovascular disease in Hutchinson-Gilford progeria syndrome provides a unique opportunity to isolate a subset of factors influencing cardiovascular disease in the general aging population.

Original languageEnglish (US)
Pages (from-to)92-97
Number of pages6
JournalHypertension
Volume59
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Keywords

  • Hutchinson-Gilford progeria syndrome
  • aging
  • arterial stiffness
  • arteriosclerosis
  • atherosclerosis
  • lamin

ASJC Scopus subject areas

  • Internal Medicine

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    Gerhard-Herman, M., Smoot, L. B., Wake, N., Kieran, M. W., Kleinman, M. E., Miller, D. T., Schwartzman, A., Giobbie-Hurder, A., Neuberg, D., & Gordon, L. B. (2012). Mechanisms of premature vascular aging in children with hutchinson-gilford progeria syndrome. Hypertension, 59(1), 92-97. https://doi.org/10.1161/HYPERTENSIONAHA.111.180919