TY - JOUR
T1 - Mechanisms of metal-induced mitochondrial dysfunction in neurological disorders
AU - Cheng, Hong
AU - Yang, Bobo
AU - Ke, Tao
AU - Li, Shaojun
AU - Yang, Xiaobo
AU - Aschner, Michael
AU - Chen, Pan
N1 - Publisher Copyright:
© 2021 by the authors.
PY - 2021/6
Y1 - 2021/6
N2 - Metals are actively involved in multiple catalytic physiological activities. However, metal overload may result in neurotoxicity as it increases formation of reactive oxygen species (ROS) and elevates oxidative stress in the nervous system. Mitochondria are a key target of metal-induced toxicity, given their role in energy production. As the brain consumes a large amount of energy, mitochondrial dysfunction and the subsequent decrease in levels of ATP may significantly disrupt brain function, resulting in neuronal cell death and ensuing neurological disorders. Here, we address contemporary studies on metal-induced mitochondrial dysfunction and its impact on the nervous system.
AB - Metals are actively involved in multiple catalytic physiological activities. However, metal overload may result in neurotoxicity as it increases formation of reactive oxygen species (ROS) and elevates oxidative stress in the nervous system. Mitochondria are a key target of metal-induced toxicity, given their role in energy production. As the brain consumes a large amount of energy, mitochondrial dysfunction and the subsequent decrease in levels of ATP may significantly disrupt brain function, resulting in neuronal cell death and ensuing neurological disorders. Here, we address contemporary studies on metal-induced mitochondrial dysfunction and its impact on the nervous system.
KW - Metals
KW - Mitochondrial dysfunction
KW - Neurological disorders
KW - Neurotoxicity
UR - http://www.scopus.com/inward/record.url?scp=85108682709&partnerID=8YFLogxK
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U2 - 10.3390/toxics9060142
DO - 10.3390/toxics9060142
M3 - Article
AN - SCOPUS:85108682709
SN - 2305-6304
VL - 9
JO - Toxics
JF - Toxics
IS - 6
M1 - 142
ER -