Mechanisms of hepatic toxicity III. Intracellular signaling in response to toxic liver injury

Brett E. Jones, Mark J. Czaja

Research output: Contribution to journalArticle

37 Scopus citations


Toxin-induced liver injury was formerly considered a passive biochemical event, but recent evidence has demonstrated that signal transduction pathways actively modulate the hepatocyte's response to this form of injury. Investigations have examined the effects of a variety of toxins on the activation of receptor-coupled signal transduction, mitogen-activated protein kinases, and Fas signaling, as well as the generation of second messengers such as ceramide and nitric oxide. Many of these pathways culminate in the activation of transcription factors such as activator protein-1, c-Myc, or nuclear factor-KB. This Themes article discusses the effects of toxic injury on these signaling pathways and their known functions in regulating hepatocyte death and proliferation following injury.

Original languageEnglish (US)
Pages (from-to)G874-G878
JournalAmerican Journal of Physiology
Issue number5 PART 1
Publication statusPublished - Dec 1 1998



  • Activator protein-1
  • C-myc
  • Ceramide
  • Fas
  • Mitogen-activated protein kinase
  • Nitric oxide
  • Nuclear factor-kb

ASJC Scopus subject areas

  • Physiology (medical)

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