Mechanisms of glutamate release from astrocytes

Gap junction "hemichannels", purinergic receptors and exocytotic release

Vladimir Parpura, Eliana Scemes, David C. Spray

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Neuronal exocytotic release of glutamate at synapses involves a highly specialized vesicular apparatus, consisting of a variety of proteins connected to the vesicles or required for vesicular fusion to the presynaptic membrane. Astrocytes also release glutamate, and recent evidence indicates that this release can modify neuronal function. Several mechanisms have been proposed for astrocytic release of glutamate under pathological conditions, such as reversal of glutamate transporters and opening of volume sensitive ion channels. In this review we limit our discussion to findings supporting the exocytotic release of glutamate, as well as two new pathways implicated in this release, the ionotropic (P2X) purinergic receptors and gap junction hemichannels.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalNeurochemistry International
Volume45
Issue number2-3
DOIs
StatePublished - Jul 2004

Fingerprint

Purinergic Receptors
Gap Junctions
Astrocytes
Glutamic Acid
Purinergic P2X Receptors
Amino Acid Transport System X-AG
Ion Channels
Synapses
Membranes
Proteins

Keywords

  • Astrocytes
  • Ca
  • Connexin " hemichannels"
  • Exocytosis
  • Glutamate release
  • P2X receptors
  • SNAREs
  • Vesicular glutamate transporters

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Mechanisms of glutamate release from astrocytes : Gap junction "hemichannels", purinergic receptors and exocytotic release. / Parpura, Vladimir; Scemes, Eliana; Spray, David C.

In: Neurochemistry International, Vol. 45, No. 2-3, 07.2004, p. 259-264.

Research output: Contribution to journalArticle

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