Mechanisms of gap junction traffic in health and disease

Geoffrey G. Hesketh, Jennifer E. Van Eyk, Gordon F. Tomaselli

Research output: Contribution to journalReview article

42 Citations (Scopus)

Abstract

Gap junctions (GJs) allow direct communication between cells. In the heart, GJs mediate the electrical coupling of cardiomyocytes and as such dictate the speed and direction of cardiac conduction. A prominent feature of acquired structural heart disease is remodeling of GJ protein expression and localization concomitant with increased susceptibility to lethal arrhythmias, leading many to hypothesize that the two are causally linked. Detailed understanding of the cellular mechanisms that regulate GJ localization and function within cardiomyocytes may therefore uncover potential therapeutic strategies for a significant clinical problem. This review will outline our current understanding of GJ cell biology with the intent of highlighting cellular mechanisms responsible for GJ remodeling associated with cardiac disease.

Original languageEnglish (US)
Pages (from-to)263-272
Number of pages10
JournalJournal of Cardiovascular Pharmacology
Volume54
Issue number4
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

Fingerprint

Gap Junctions
Health
Cardiac Myocytes
Heart Diseases
Connexins
Cell Communication
Cell Biology
Cardiac Arrhythmias

Keywords

  • Arrhythmia
  • Connexin 43
  • Gap junctions
  • Protein trafficking
  • Structural heart disease

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Mechanisms of gap junction traffic in health and disease. / Hesketh, Geoffrey G.; Van Eyk, Jennifer E.; Tomaselli, Gordon F.

In: Journal of Cardiovascular Pharmacology, Vol. 54, No. 4, 01.10.2009, p. 263-272.

Research output: Contribution to journalReview article

Hesketh, Geoffrey G. ; Van Eyk, Jennifer E. ; Tomaselli, Gordon F. / Mechanisms of gap junction traffic in health and disease. In: Journal of Cardiovascular Pharmacology. 2009 ; Vol. 54, No. 4. pp. 263-272.
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