Abstract
Purpose of Review: Activated fibroblasts are critically implicated in repair and remodeling of the injured heart. This manuscript discusses recent progress in the cell biology of fibroblasts in the infarcted and remodeling myocardium, highlighting advances in understanding the origin, function, and mechanisms of activation of these cells. Recent Findings: Following myocardial injury, fibroblasts undergo activation and myofibroblast transdifferentiation. Recently published studies have suggested that most activated myofibroblasts in the infarcted and pressure-overloaded hearts are derived from resident fibroblast populations. In the healing infarct, fibroblasts undergo dynamic phenotypic alterations in response to changes in the cytokine milieu and in the composition of the extracellular matrix. Fibroblasts do not simply serve as matrix-producing cells, but may also regulate inflammation, modulate cardiomyocyte survival and function, mediate angiogenesis, and contribute to phagocytosis of dead cells. Summary: In the injured myocardium, fibroblasts are derived predominantly from resident populations and serve a wide range of functions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 145-152 |
| Number of pages | 8 |
| Journal | Current Pathobiology Reports |
| Volume | 5 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2017 |
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Keywords
- Cardiac remodeling
- Cytokine
- Fibroblast
- Myocardial infarction
- Myofibroblast
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Pathology and Forensic Medicine
- Cancer Research
Cite this
Mechanisms of Fibroblast Activation in the Remodeling Myocardium. / Shinde, Arti V.; Frangogiannis, Nikolaos G.
In: Current Pathobiology Reports, Vol. 5, No. 2, 01.06.2017, p. 145-152.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Mechanisms of Fibroblast Activation in the Remodeling Myocardium
AU - Shinde, Arti V.
AU - Frangogiannis, Nikolaos G.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Purpose of Review: Activated fibroblasts are critically implicated in repair and remodeling of the injured heart. This manuscript discusses recent progress in the cell biology of fibroblasts in the infarcted and remodeling myocardium, highlighting advances in understanding the origin, function, and mechanisms of activation of these cells. Recent Findings: Following myocardial injury, fibroblasts undergo activation and myofibroblast transdifferentiation. Recently published studies have suggested that most activated myofibroblasts in the infarcted and pressure-overloaded hearts are derived from resident fibroblast populations. In the healing infarct, fibroblasts undergo dynamic phenotypic alterations in response to changes in the cytokine milieu and in the composition of the extracellular matrix. Fibroblasts do not simply serve as matrix-producing cells, but may also regulate inflammation, modulate cardiomyocyte survival and function, mediate angiogenesis, and contribute to phagocytosis of dead cells. Summary: In the injured myocardium, fibroblasts are derived predominantly from resident populations and serve a wide range of functions.
AB - Purpose of Review: Activated fibroblasts are critically implicated in repair and remodeling of the injured heart. This manuscript discusses recent progress in the cell biology of fibroblasts in the infarcted and remodeling myocardium, highlighting advances in understanding the origin, function, and mechanisms of activation of these cells. Recent Findings: Following myocardial injury, fibroblasts undergo activation and myofibroblast transdifferentiation. Recently published studies have suggested that most activated myofibroblasts in the infarcted and pressure-overloaded hearts are derived from resident fibroblast populations. In the healing infarct, fibroblasts undergo dynamic phenotypic alterations in response to changes in the cytokine milieu and in the composition of the extracellular matrix. Fibroblasts do not simply serve as matrix-producing cells, but may also regulate inflammation, modulate cardiomyocyte survival and function, mediate angiogenesis, and contribute to phagocytosis of dead cells. Summary: In the injured myocardium, fibroblasts are derived predominantly from resident populations and serve a wide range of functions.
KW - Cardiac remodeling
KW - Cytokine
KW - Fibroblast
KW - Myocardial infarction
KW - Myofibroblast
UR - http://www.scopus.com/inward/record.url?scp=85051216065&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051216065&partnerID=8YFLogxK
U2 - 10.1007/s40139-017-0132-z
DO - 10.1007/s40139-017-0132-z
M3 - Review article
VL - 5
SP - 145
EP - 152
JO - Current Pathobiology Reports
JF - Current Pathobiology Reports
SN - 2167-485X
IS - 2
ER -