TY - JOUR
T1 - Mechanisms of Fibroblast Activation in the Remodeling Myocardium
AU - Shinde, Arti V.
AU - Frangogiannis, Nikolaos G.
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media New York.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Purpose of Review: Activated fibroblasts are critically implicated in repair and remodeling of the injured heart. This manuscript discusses recent progress in the cell biology of fibroblasts in the infarcted and remodeling myocardium, highlighting advances in understanding the origin, function, and mechanisms of activation of these cells. Recent Findings: Following myocardial injury, fibroblasts undergo activation and myofibroblast transdifferentiation. Recently published studies have suggested that most activated myofibroblasts in the infarcted and pressure-overloaded hearts are derived from resident fibroblast populations. In the healing infarct, fibroblasts undergo dynamic phenotypic alterations in response to changes in the cytokine milieu and in the composition of the extracellular matrix. Fibroblasts do not simply serve as matrix-producing cells, but may also regulate inflammation, modulate cardiomyocyte survival and function, mediate angiogenesis, and contribute to phagocytosis of dead cells. Summary: In the injured myocardium, fibroblasts are derived predominantly from resident populations and serve a wide range of functions.
AB - Purpose of Review: Activated fibroblasts are critically implicated in repair and remodeling of the injured heart. This manuscript discusses recent progress in the cell biology of fibroblasts in the infarcted and remodeling myocardium, highlighting advances in understanding the origin, function, and mechanisms of activation of these cells. Recent Findings: Following myocardial injury, fibroblasts undergo activation and myofibroblast transdifferentiation. Recently published studies have suggested that most activated myofibroblasts in the infarcted and pressure-overloaded hearts are derived from resident fibroblast populations. In the healing infarct, fibroblasts undergo dynamic phenotypic alterations in response to changes in the cytokine milieu and in the composition of the extracellular matrix. Fibroblasts do not simply serve as matrix-producing cells, but may also regulate inflammation, modulate cardiomyocyte survival and function, mediate angiogenesis, and contribute to phagocytosis of dead cells. Summary: In the injured myocardium, fibroblasts are derived predominantly from resident populations and serve a wide range of functions.
KW - Cardiac remodeling
KW - Cytokine
KW - Fibroblast
KW - Myocardial infarction
KW - Myofibroblast
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U2 - 10.1007/s40139-017-0132-z
DO - 10.1007/s40139-017-0132-z
M3 - Review article
AN - SCOPUS:85051216065
VL - 5
SP - 145
EP - 152
JO - Current Pathobiology Reports
JF - Current Pathobiology Reports
SN - 2167-485X
IS - 2
ER -