Mechanisms of Fibroblast Activation in the Remodeling Myocardium

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Purpose of Review: Activated fibroblasts are critically implicated in repair and remodeling of the injured heart. This manuscript discusses recent progress in the cell biology of fibroblasts in the infarcted and remodeling myocardium, highlighting advances in understanding the origin, function, and mechanisms of activation of these cells. Recent Findings: Following myocardial injury, fibroblasts undergo activation and myofibroblast transdifferentiation. Recently published studies have suggested that most activated myofibroblasts in the infarcted and pressure-overloaded hearts are derived from resident fibroblast populations. In the healing infarct, fibroblasts undergo dynamic phenotypic alterations in response to changes in the cytokine milieu and in the composition of the extracellular matrix. Fibroblasts do not simply serve as matrix-producing cells, but may also regulate inflammation, modulate cardiomyocyte survival and function, mediate angiogenesis, and contribute to phagocytosis of dead cells. Summary: In the injured myocardium, fibroblasts are derived predominantly from resident populations and serve a wide range of functions.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalCurrent Pathobiology Reports
Volume5
Issue number2
DOIs
StatePublished - Jun 1 2017

Fingerprint

Myocardium
Fibroblasts
Myofibroblasts
Cytophagocytosis
Cardiac Myocytes
Population
Extracellular Matrix
Cell Biology
Cytokines
Inflammation
Pressure
Wounds and Injuries

Keywords

  • Cardiac remodeling
  • Cytokine
  • Fibroblast
  • Myocardial infarction
  • Myofibroblast

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pathology and Forensic Medicine
  • Cancer Research

Cite this

Mechanisms of Fibroblast Activation in the Remodeling Myocardium. / Shinde, Arti V.; Frangogiannis, Nikolaos G.

In: Current Pathobiology Reports, Vol. 5, No. 2, 01.06.2017, p. 145-152.

Research output: Contribution to journalReview article

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N2 - Purpose of Review: Activated fibroblasts are critically implicated in repair and remodeling of the injured heart. This manuscript discusses recent progress in the cell biology of fibroblasts in the infarcted and remodeling myocardium, highlighting advances in understanding the origin, function, and mechanisms of activation of these cells. Recent Findings: Following myocardial injury, fibroblasts undergo activation and myofibroblast transdifferentiation. Recently published studies have suggested that most activated myofibroblasts in the infarcted and pressure-overloaded hearts are derived from resident fibroblast populations. In the healing infarct, fibroblasts undergo dynamic phenotypic alterations in response to changes in the cytokine milieu and in the composition of the extracellular matrix. Fibroblasts do not simply serve as matrix-producing cells, but may also regulate inflammation, modulate cardiomyocyte survival and function, mediate angiogenesis, and contribute to phagocytosis of dead cells. Summary: In the injured myocardium, fibroblasts are derived predominantly from resident populations and serve a wide range of functions.

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