Mechanisms for fiber-type specificity of skeletal muscle atrophy

Yichen Wang, Jeffrey E. Pessin

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: There are a variety of pathophysiologic conditions that are known to induce skeletal muscle atrophy. However, muscle wasting can occur through multiple distinct signaling pathways with differential sensitivity between selective skeletal muscle fiber subtypes. This review summarizes some of the underlying molecular mechanisms responsible for fiber-specific muscle mass regulation. RECENT FINDINGS: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha protects slow-twitch oxidative fibers from denervation/immobilization (disuse)-induced muscle atrophies. Nutrient-related muscle atrophies, such as those induced by cancer cachexia, sepsis, chronic heart failure, or diabetes, are largely restricted to fast-twitch glycolytic fibers, of which the underlying mechanism is usually related to abnormality of protein degradation, including proteasomal and lysosomal pathways. In contrast, nuclear factor kappaB activation apparently serves a dual function by inducing both fast-twitch fiber atrophy and slow-twitch fiber degeneration. SUMMARY: Fast-twitch glycolytic fibers are more vulnerable than slow-twitch oxidative fibers under a variety of atrophic conditions related to signaling transduction of Forkhead box O family, autophagy inhibition, transforming growth factor beta family, and nuclear factor-kappaB. The resistance of oxidative fibers may result from the protection of peroxisome proliferator-activated receptor gamma coactivator 1-alpha.

Original languageEnglish (US)
Pages (from-to)243-250
Number of pages8
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Volume16
Issue number3
DOIs
StatePublished - May 2013

Fingerprint

Muscular Atrophy
Muscles
Cachexia
Skeletal Muscle Fibers
Autophagy
Denervation
Nuclear Family
Immobilization
Transforming Growth Factor beta
Proteolysis
Atrophy
Sepsis
Skeletal Muscle
Heart Failure
Food
Neoplasms
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Keywords

  • fiber-specific atrophy
  • signaling
  • skeletal muscle

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Mechanisms for fiber-type specificity of skeletal muscle atrophy. / Wang, Yichen; Pessin, Jeffrey E.

In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 16, No. 3, 05.2013, p. 243-250.

Research output: Contribution to journalArticle

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