Mechanisms and modifiers of methylmercury-induced neurotoxicity

Stephanie J B Fretham, Samuel Caito, Ebany J. Martinez-Finley, Michael Aschner

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The neurotoxic consequences of methylmercury (MeHg) exposure have long been known, however a complete understanding of the mechanisms underlying this toxicity is elusive. Recent epidemiological and experimental studies have provided mechanistic insights into the contribution of genetic and environmental factors that interact with MeHg to modify toxicity. This review will outline cellular processes directly and indirectly affected by MeHg, including oxidative stress, cellular signaling and gene expression, and discuss epigenetic modifications, genetic polymorphisms and gene-environment interactions capable of modifying MeHg neurotoxicity. This journal is

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalToxicology Research
Volume1
Issue number1
DOIs
StatePublished - 2012
Externally publishedYes

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Gene-Environment Interaction
Genetic Polymorphisms
Epigenomics
Toxicity
Epidemiologic Studies
Oxidative Stress
Cell signaling
Gene Expression
Oxidative stress
Polymorphism
Gene expression
Genes

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Mechanisms and modifiers of methylmercury-induced neurotoxicity. / Fretham, Stephanie J B; Caito, Samuel; Martinez-Finley, Ebany J.; Aschner, Michael.

In: Toxicology Research, Vol. 1, No. 1, 2012, p. 32-38.

Research output: Contribution to journalArticle

Fretham, Stephanie J B ; Caito, Samuel ; Martinez-Finley, Ebany J. ; Aschner, Michael. / Mechanisms and modifiers of methylmercury-induced neurotoxicity. In: Toxicology Research. 2012 ; Vol. 1, No. 1. pp. 32-38.
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