Mechanisms and modifiers of methylmercury-induced neurotoxicity

Stephanie J.B. Fretham, Samuel Caito, Ebany J. Martinez-Finley, Michael Aschner

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

The neurotoxic consequences of methylmercury (MeHg) exposure have long been known, however a complete understanding of the mechanisms underlying this toxicity is elusive. Recent epidemiological and experimental studies have provided mechanistic insights into the contribution of genetic and environmental factors that interact with MeHg to modify toxicity. This review will outline cellular processes directly and indirectly affected by MeHg, including oxidative stress, cellular signaling and gene expression, and discuss epigenetic modifications, genetic polymorphisms and gene-environment interactions capable of modifying MeHg neurotoxicity.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalToxicology Research
Volume1
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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