Mechanisms and cellular roles of local protein synthesis in mammalian cells

Alexis J. Rodriguez, Kevin Czaplinski, John S. Condeelis, Robert H. Singer

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations

Abstract

After the export from the nucleus it turns out that all mRNAs are not treated equally. Not only is mRNA subject to translation, but also through RNA-binding proteins and other trans-acting factors, eukaryotic cells interpret codes for spatial sorting within the mRNA sequence. These codes instruct the cytoskeleton and translation apparatus to make decisions about where to transport and when to translate the intended protein product. Signaling pathways decode extra-cellular cues and can modify transport and translation factors in the appropriate cytoplasmic space to achieve translation locally. Identifying regulatory sites on transport factors as well as novel physiological functions for well-known translation factors has provided significant advances in how spatially controlled translation impacts cell function.

Original languageEnglish (US)
Pages (from-to)144-149
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume20
Issue number2
DOIs
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Cell Biology

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