Mechanism of bleomycin action

In vitro studies

Richard M. Burger, Jack Peisach, Susan Band Horwitz

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

The cytotoxic activity of bleomucin results from DNA cleavage, which is also accomplished in vitro by reaction mixtures containing Fe(II), drug and O2. Bleomycin forms a complex with Fe(II) and O2 in the presence or absence of DNA. The species attacking DNA forms rapidly from this complex. The nature of the attacking species and of the primary lesion(s) to DNA are not yet known, but two major insults to DNA have been characterized. They are the release of free bases from their glycosidic linkages and, at other residues, the cleavage of the polymer backbone at the deoxyribose C3-C4 bond.

Original languageEnglish (US)
Pages (from-to)715-727
Number of pages13
JournalLife Sciences
Volume28
Issue number7
DOIs
StatePublished - Feb 16 1981

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Bleomycin
DNA
Deoxyribose
DNA Cleavage
Polymers
In Vitro Techniques
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Mechanism of bleomycin action : In vitro studies. / Burger, Richard M.; Peisach, Jack; Band Horwitz, Susan.

In: Life Sciences, Vol. 28, No. 7, 16.02.1981, p. 715-727.

Research output: Contribution to journalArticle

Burger, Richard M. ; Peisach, Jack ; Band Horwitz, Susan. / Mechanism of bleomycin action : In vitro studies. In: Life Sciences. 1981 ; Vol. 28, No. 7. pp. 715-727.
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