Mechanism-based inhibitors of CD38: A mammalian cyclic ADP-ribose synthetase

Medicine & Life Sciences

• Cyclic ADP-Ribose 95%
• Niacinamide 76%
• Ligases 66%
• Hydroxyl Radical 33%
• cyclic guanosine diphosphate-ribose 33%
• 5-methylnicotinamide 32%
• nicotinamide guanine dinucleotide 32%
• Hydrolysis 28%
• Competitive Behavior 26%
• Psychological Inhibition 24%
• Deoxyribose 23%
• Cyclization 22%
• Adenosine Diphosphate Ribose 22%
• Aptitude 20%
• Catalysis 18%
• Enzyme Inhibitors 17%
• Enzymes 16%
• Nucleosides 16%
• NAD 15%
• Catalytic Domain 13%
• Phosphates 13%

Chemical Compounds

• Cyclic ADP-ribose 100%
• Nicotinamide 65%
• Koff 44%
• Nicotinamide Guanine Dinucleotide 30%
• Nucleophile 26%
• Hydrolysis 18%
• Dissociation Constant 14%
• Nucleoside 13%
• Enzyme Activity 12%
• Cyclization Reaction 11%
• Rate Constant 9%
• Catalysis 9%