Mechanical loading

Bone remodeling and cartilage maintenance

Hiroki Yokota, Daniel J. Leong, Hui (Herb) Sun

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Bone remodeling and cartilage maintenance are strongly influenced by biomechanical signals generated by mechanical loading. Although moderate loading is required to maintain bone mass and cartilage homeostasis, loading can cause deleterious effects such as bone fracture and cartilage degradation. Because a tight coupling exists between cartilage and bone, alterations in one tissue can affect the other. Bone marrow lesions are often associated with an increased risk of developing cartilage defects, and changes in the articular cartilage integrity are linked to remodeling responses in the underlying bone. Although mechanisms regulating the maintenance of these two tissues are different, compelling evidence indicates that the signal pathways crosstalk, particularly with the Wnt pathway. A better understanding of the complex tempero-spatial interplay between bone remodeling and cartilage degeneration will help develop a therapeutic loading strategy that prevents bone loss and cartilage degeneration.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalCurrent Osteoporosis Reports
Volume9
Issue number4
DOIs
StatePublished - Dec 2011
Externally publishedYes

Fingerprint

Bone Remodeling
Cartilage
Maintenance
Bone and Bones
Wnt Signaling Pathway
Bone Fractures
Articular Cartilage
Signal Transduction
Homeostasis
Bone Marrow

Keywords

  • Bone remodeling
  • Cartilage maintenance
  • Exercise
  • Joint loading
  • Mechanical loading
  • Mechanotransduction
  • Osteoarthritis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Mechanical loading : Bone remodeling and cartilage maintenance. / Yokota, Hiroki; Leong, Daniel J.; Sun, Hui (Herb).

In: Current Osteoporosis Reports, Vol. 9, No. 4, 12.2011, p. 237-242.

Research output: Contribution to journalArticle

Yokota, Hiroki ; Leong, Daniel J. ; Sun, Hui (Herb). / Mechanical loading : Bone remodeling and cartilage maintenance. In: Current Osteoporosis Reports. 2011 ; Vol. 9, No. 4. pp. 237-242.
@article{3ffe054037bb49b1998f0e7109de40f2,
title = "Mechanical loading: Bone remodeling and cartilage maintenance",
abstract = "Bone remodeling and cartilage maintenance are strongly influenced by biomechanical signals generated by mechanical loading. Although moderate loading is required to maintain bone mass and cartilage homeostasis, loading can cause deleterious effects such as bone fracture and cartilage degradation. Because a tight coupling exists between cartilage and bone, alterations in one tissue can affect the other. Bone marrow lesions are often associated with an increased risk of developing cartilage defects, and changes in the articular cartilage integrity are linked to remodeling responses in the underlying bone. Although mechanisms regulating the maintenance of these two tissues are different, compelling evidence indicates that the signal pathways crosstalk, particularly with the Wnt pathway. A better understanding of the complex tempero-spatial interplay between bone remodeling and cartilage degeneration will help develop a therapeutic loading strategy that prevents bone loss and cartilage degeneration.",
keywords = "Bone remodeling, Cartilage maintenance, Exercise, Joint loading, Mechanical loading, Mechanotransduction, Osteoarthritis",
author = "Hiroki Yokota and Leong, {Daniel J.} and Sun, {Hui (Herb)}",
year = "2011",
month = "12",
doi = "10.1007/s11914-011-0067-y",
language = "English (US)",
volume = "9",
pages = "237--242",
journal = "Current Osteoporosis Reports",
issn = "1544-1873",
publisher = "Current Science, Inc.",
number = "4",

}

TY - JOUR

T1 - Mechanical loading

T2 - Bone remodeling and cartilage maintenance

AU - Yokota, Hiroki

AU - Leong, Daniel J.

AU - Sun, Hui (Herb)

PY - 2011/12

Y1 - 2011/12

N2 - Bone remodeling and cartilage maintenance are strongly influenced by biomechanical signals generated by mechanical loading. Although moderate loading is required to maintain bone mass and cartilage homeostasis, loading can cause deleterious effects such as bone fracture and cartilage degradation. Because a tight coupling exists between cartilage and bone, alterations in one tissue can affect the other. Bone marrow lesions are often associated with an increased risk of developing cartilage defects, and changes in the articular cartilage integrity are linked to remodeling responses in the underlying bone. Although mechanisms regulating the maintenance of these two tissues are different, compelling evidence indicates that the signal pathways crosstalk, particularly with the Wnt pathway. A better understanding of the complex tempero-spatial interplay between bone remodeling and cartilage degeneration will help develop a therapeutic loading strategy that prevents bone loss and cartilage degeneration.

AB - Bone remodeling and cartilage maintenance are strongly influenced by biomechanical signals generated by mechanical loading. Although moderate loading is required to maintain bone mass and cartilage homeostasis, loading can cause deleterious effects such as bone fracture and cartilage degradation. Because a tight coupling exists between cartilage and bone, alterations in one tissue can affect the other. Bone marrow lesions are often associated with an increased risk of developing cartilage defects, and changes in the articular cartilage integrity are linked to remodeling responses in the underlying bone. Although mechanisms regulating the maintenance of these two tissues are different, compelling evidence indicates that the signal pathways crosstalk, particularly with the Wnt pathway. A better understanding of the complex tempero-spatial interplay between bone remodeling and cartilage degeneration will help develop a therapeutic loading strategy that prevents bone loss and cartilage degeneration.

KW - Bone remodeling

KW - Cartilage maintenance

KW - Exercise

KW - Joint loading

KW - Mechanical loading

KW - Mechanotransduction

KW - Osteoarthritis

UR - http://www.scopus.com/inward/record.url?scp=81255160693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81255160693&partnerID=8YFLogxK

U2 - 10.1007/s11914-011-0067-y

DO - 10.1007/s11914-011-0067-y

M3 - Article

VL - 9

SP - 237

EP - 242

JO - Current Osteoporosis Reports

JF - Current Osteoporosis Reports

SN - 1544-1873

IS - 4

ER -