Meat intake and meat preparation in relation to risk of postmenopausal breast cancer in the NIH-AARP diet and health study

Geoffrey C. Kabat, Amanda J. Cross, Yikyung Park, Arthur Schatzkin, Albert R. Hollenbeck, Thomas E. Rohan, Rashmi Sinha

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A number of studies have reported that intake of red meat or meat cooked at high temperatures is associated with increased risk of breast cancer, but other studies have shown no association. We assessed the association between meat, meat-cooking methods, and meat-mutagen intake and postmenopausal breast cancer in the NIH-AARP Diet and Health Study cohort of 120,755 postmenopausal women who completed a food frequency questionnaire at baseline (1995-1996) as well as a detailed meat-cooking module within 6 months following baseline. During 8 years of follow-up, 3,818 cases of invasive breast cancer were identified in this cohort. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI). After adjusting for covariates, intake of total meat, red meat, meat cooked at high temperatures, and meat mutagens showed no association with breast cancer risk. This large prospective study with detailed information on meat preparation methods provides no support for a role of meat mutagens in the development of postmenopausal breast cancer.

Original languageEnglish (US)
Pages (from-to)2430-2435
Number of pages6
JournalInternational Journal of Cancer
Volume124
Issue number10
DOIs
StatePublished - May 15 2009

Fingerprint

Meat
Breast Neoplasms
Diet
Health
Mutagens
Cooking
Temperature
Proportional Hazards Models
Cohort Studies
Prospective Studies
Confidence Intervals
Food

Keywords

  • Breast neoplasms
  • Heterocyclic amines
  • High temperature cooking
  • Meat mutagens

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Meat intake and meat preparation in relation to risk of postmenopausal breast cancer in the NIH-AARP diet and health study. / Kabat, Geoffrey C.; Cross, Amanda J.; Park, Yikyung; Schatzkin, Arthur; Hollenbeck, Albert R.; Rohan, Thomas E.; Sinha, Rashmi.

In: International Journal of Cancer, Vol. 124, No. 10, 15.05.2009, p. 2430-2435.

Research output: Contribution to journalArticle

Kabat, Geoffrey C. ; Cross, Amanda J. ; Park, Yikyung ; Schatzkin, Arthur ; Hollenbeck, Albert R. ; Rohan, Thomas E. ; Sinha, Rashmi. / Meat intake and meat preparation in relation to risk of postmenopausal breast cancer in the NIH-AARP diet and health study. In: International Journal of Cancer. 2009 ; Vol. 124, No. 10. pp. 2430-2435.
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