TY - JOUR
T1 - Meat consumption and pancreatic cancer risk among men and women in the Cancer Prevention Study-II Nutrition Cohort
AU - McCullough, Marjorie L.
AU - Jacobs, Eric J.
AU - Shah, Roma
AU - Campbell, Peter T.
AU - Wang, Ying
AU - Hartman, Terryl J.
AU - Gapstur, Susan M.
N1 - Funding Information:
Acknowledgments The authors express sincere appreciation to all Cancer Prevention Study-II participants, and to each member of the study and biospecimen management group. The authors would like to acknowledge the contribution to this study from central cancer registries supported through the Centers for Disease Control and Prevention’s National Program of Cancer Registries and cancer registries supported by the National Cancer Institute’s Surveillance Epidemiology and End Results Program. The American Cancer Society supports the maintenance and follow-up of the Cancer Prevention Studies. The American Cancer Society also supported all investigators during the conduct of this analysis.
Funding Information:
The authors express sincere appreciation to all Cancer Prevention Study-II participants, and to each member of the study and biospecimen management group. The authors would like to acknowledge the contribution to this study from central cancer registries supported through the Centers for Disease Control and Prevention?s National Program of Cancer Registries and cancer registries supported by the National Cancer Institute?s Surveillance Epidemiology and End Results Program. The American Cancer Society supports the maintenance and follow-up of the Cancer Prevention Studies. The American Cancer Society also supported all investigators during the conduct of this analysis. The authors declare that they have no conflict of interest.
Publisher Copyright:
© 2017, Springer International Publishing AG, part of Springer Nature.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Purpose: Prospective cohort studies suggest that red and processed meat consumption is associated with increased risk of pancreatic cancer among men, but not women. However, evidence is limited, and less evidence exists for other types of meat. Methods: Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HR) for the association of meat consumption, by type, with pancreatic cancer risk among 138,266 men and women in the Cancer Prevention Study-II Nutrition Cohort. Diet was assessed at baseline in 1992, and 10 years earlier, at enrollment into the parent CPS-II mortality cohort. 1,156 pancreatic cancers were verified through 2013. Results: Red meat, processed meat, and fish intake at baseline were not associated with pancreatic cancer risk. However, for long-term red and processed meat consumption (highest quartiles in 1982 and 1992, vs. lowest quartiles), risk appeared different in men [hazard ratio (HR) 1.32, 95% confidence interval (CI) 0.90, 1.95] and women (HR 0.72, 95% CI 0.47, 1.10, p heterogeneity by sex = 0.05). Poultry consumption in 1992 was associated with increased pancreatic cancer risk (HR 1.27, 95% CI 1.04, 1.55, p trend = 0.01, top vs. bottom quintile). Conclusions: The associations of meat consumption with pancreatic cancer risk remain unclear and further research, particularly of long-term intake, is warranted.
AB - Purpose: Prospective cohort studies suggest that red and processed meat consumption is associated with increased risk of pancreatic cancer among men, but not women. However, evidence is limited, and less evidence exists for other types of meat. Methods: Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HR) for the association of meat consumption, by type, with pancreatic cancer risk among 138,266 men and women in the Cancer Prevention Study-II Nutrition Cohort. Diet was assessed at baseline in 1992, and 10 years earlier, at enrollment into the parent CPS-II mortality cohort. 1,156 pancreatic cancers were verified through 2013. Results: Red meat, processed meat, and fish intake at baseline were not associated with pancreatic cancer risk. However, for long-term red and processed meat consumption (highest quartiles in 1982 and 1992, vs. lowest quartiles), risk appeared different in men [hazard ratio (HR) 1.32, 95% confidence interval (CI) 0.90, 1.95] and women (HR 0.72, 95% CI 0.47, 1.10, p heterogeneity by sex = 0.05). Poultry consumption in 1992 was associated with increased pancreatic cancer risk (HR 1.27, 95% CI 1.04, 1.55, p trend = 0.01, top vs. bottom quintile). Conclusions: The associations of meat consumption with pancreatic cancer risk remain unclear and further research, particularly of long-term intake, is warranted.
KW - Diet
KW - Meat
KW - Pancreatic cancer
KW - Processed meat
KW - Prospective cohort study
KW - Red meat
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U2 - 10.1007/s10552-017-0984-x
DO - 10.1007/s10552-017-0984-x
M3 - Article
C2 - 29185090
AN - SCOPUS:85035104721
VL - 29
SP - 125
EP - 133
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 1
ER -
