Measuring bioimpedance in the human uterine cervix

Towards early detection of preterm labor

Yen Shi Gillian Hoe, Edith D. Gurewitsch Allen, Ashkon Shaahinfar, Elbert S. Hu, Somponnat Sampattavanich, Melanie Ruffner, Kenny H.S. Ching, Robert H. Allen

Research output: Contribution to journalConference article

4 Citations (Scopus)

Abstract

We have created a bioimpedance probe designed to detect subtle changes in human cervical tissue composition in vivo, and thereby detect the onset of cervical remodeling in a non-invasive manner sooner than existing clinical methods allow. Our cervical bioimpedance measurement device, which can be used during a routine pelvic examination, is composed of a contoured probe with disposable tip and, within the probe's handle, a bioimpedance sensor equipped with an integrated chip capable of generating sinusoidal voltage of varying frequencies. A constant force spring assures consistent measurements through a range of contact forces applied. An activation switch allows the operator to control the application of current. The sensor can be synchronized with a computer data storage and analysis system, which interfaces with the device. With the probe placed in contact with a collagen gels of varying concentration, the relationship between measured bioimpedance and collagen concentration is verified to be positive exponential (R 2 = 0.94) and repeatability in saline solution showed that measurements varied by less than ±10% over 20 trials. Finally, a variety of user-applied forces showed that impedance values plateau when forces exceed 1N.

Original languageEnglish (US)
Pages (from-to)2368-2372
Number of pages5
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume26 IV
StatePublished - Dec 1 2004
Externally publishedYes
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

Fingerprint

Premature Obstetric Labor
Cervix Uteri
Collagen
Personnel
Equipment and Supplies
Gynecological Examination
Information Storage and Retrieval
Electric Impedance
Sodium Chloride
Gels
Sensors
Interfaces (computer)
Computer systems
Chemical activation
Switches
Tissue
Data storage equipment
Electric potential
Chemical analysis

Keywords

  • Bioimpedance
  • Cervical ripeness
  • Cervical tissue composition
  • Human uterine cervix
  • Impedance measurement
  • Linear tetrapolar electrodes
  • Non-invasive tissue analysis
  • Pregnancy
  • Preterm labor
  • Probe
  • Tetrapolar

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Measuring bioimpedance in the human uterine cervix : Towards early detection of preterm labor. / Hoe, Yen Shi Gillian; Gurewitsch Allen, Edith D.; Shaahinfar, Ashkon; Hu, Elbert S.; Sampattavanich, Somponnat; Ruffner, Melanie; Ching, Kenny H.S.; Allen, Robert H.

In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 26 IV, 01.12.2004, p. 2368-2372.

Research output: Contribution to journalConference article

Hoe, Yen Shi Gillian ; Gurewitsch Allen, Edith D. ; Shaahinfar, Ashkon ; Hu, Elbert S. ; Sampattavanich, Somponnat ; Ruffner, Melanie ; Ching, Kenny H.S. ; Allen, Robert H. / Measuring bioimpedance in the human uterine cervix : Towards early detection of preterm labor. In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2004 ; Vol. 26 IV. pp. 2368-2372.
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