Measurements of ascorbic acid and glutathione in exfoliated cervicovaginal epithelial cells of smokers and women with cervical dysplasias

Jayasri Basu, Magdy S. Mikhail, Gary L. Goldberg, Prabhudas R. Palan, Seymour L. Romney

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This report emphasizes the ability to quantify ascorbic acid (AA) and reduced glutathione (GSH) levels in exfoliated cervicovaginal epithelial cells obtained by a lavage technique. Sixty-two women with abnormal Papanicolaou smears underwent colposcopie examinations. Colposcopie lesions were biopsied and histopathologically graded. Marked variations in the number of cells and in the levels of AA and GSH were observed. In cigarette smokers, the number of exfoliated cells retrieved was significantly higher (p < 0.05, by Student’s t test). The simultaneous investigation of biochemical and virologie parameters in exfoliated cervicovaginal epithelial cells, in conjunction with the known cytopathologic and epidemiologic risk variables, provides a novel approach to elucidate factor(s) that may inhibit or promote cervical carcinogenesis in designed prospective studies.

Original languageEnglish (US)
Pages (from-to)48-51
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume30
Issue number1
DOIs
StatePublished - 1990

Fingerprint

Uterine Cervical Dysplasia
Ascorbic Acid
Glutathione
Cell Count
Epithelial Cells
Papanicolaou Test
Therapeutic Irrigation
Tobacco Products
Carcinogenesis
Prospective Studies
Students

Keywords

  • Abnormal papanicolaou smear
  • Cervical intraepithelial neoplasia
  • Cervical wash
  • Histopathology
  • Lavage technique
  • Vitamin C

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Measurements of ascorbic acid and glutathione in exfoliated cervicovaginal epithelial cells of smokers and women with cervical dysplasias. / Basu, Jayasri; Mikhail, Magdy S.; Goldberg, Gary L.; Palan, Prabhudas R.; Romney, Seymour L.

In: Gynecologic and Obstetric Investigation, Vol. 30, No. 1, 1990, p. 48-51.

Research output: Contribution to journalArticle

Basu, Jayasri ; Mikhail, Magdy S. ; Goldberg, Gary L. ; Palan, Prabhudas R. ; Romney, Seymour L. / Measurements of ascorbic acid and glutathione in exfoliated cervicovaginal epithelial cells of smokers and women with cervical dysplasias. In: Gynecologic and Obstetric Investigation. 1990 ; Vol. 30, No. 1. pp. 48-51.
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