Meal-synchronized CEA in rats: Effects of meal size, intragastric feeding, and subdiaphragmatic vagotomy

Wesley White, Gary J. Schwartz, Timothy H. Moran

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Within a feeding schedule of intermittent food access, large meals have the ability to induce activity at the same time the next day [circadian ensuing activity (CEA)]. In these experiments, we evaluated the minimum meal size necessary to induce CEA and whether oral-pharyngeal factors and afferent vagal activity played necessary roles in the induction of the underlying process. In experiment 1, every 33 h rats were given two meals separated by a 2-h interval. The size of the first meal was varied, while total intake every feeding cycle was held constant. When the initial meal was <10 g (34 kcal) CEA occurred later, indicating that such a meal size was subthreshold for inducing CEA. In experiment 2, rats were given intragastric (IG) meals every 33 h, before and after complete subdiaphragmatic vagotomy. IG nutrient meals induced CEA, indicating that extensive oral-pharyngeal experience was not necessary for CEA induction. CEA occurred in vagotomized rats but, compared with intact rats, appeared to occur later relative to nutrient infusion, indicating that afferent vagal activity may be sufficient but not necessary to induce CEA.

Original languageEnglish (US)
Pages (from-to)R1276-R1288
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume276
Issue number5 45-5
DOIs
StatePublished - May 1999
Externally publishedYes

Keywords

  • Circadian ensuing activity
  • Circadian rhythm
  • Entrainment
  • Food intake
  • Food-anticipatory activity
  • Food-entrainable oscillator
  • Transduction

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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