Mbd4 inactivation increases C→T transition mutations and promotes gastrointestinal tumor formation

Medicine & Life Sciences

• Methyl CpG Binding Domain 100%
• Mutation 33%
• Neoplasms 19%
• MutL Protein Homolog 1 11%
• APC Genes 10%
• Adenomatous Polyposis Coli 9%
• Microsatellite Instability 9%
• Phenotype 8%
• DNA Mismatch Repair 8%
• Gastrointestinal Neoplasms 8%
• Gene Targeting 8%
• Loss of Function Mutation 8%
• Germ-Line Mutation 8%
• Intestinal Mucosa 7%
• DNA Repair 6%
• Gastrointestinal Tract 6%
• Carcinogenesis 5%
• Alleles 5%
• Epithelial Cells 5%
• Genome 5%
• Survival 4%
• Enzymes 4%
• Genes 2%
• Proteins 2%