Maturation and segregation of brain networks that modify seizures

Solomon L. Moshé, Lucy L. Brown, Hana Kubová, Jana Velíšková, R. S. Zukin, Ellen F. Sperber

Research output: Contribution to journalArticle

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Abstract

The mature brain is less susceptible to seizures than the immature brain. We demonstrate that in the mature substantia nigra (SN) there are two topographically discrete GABAA-sensitive regions which differ in the amount of mRNA expression of the GABAAa receptor δ1 subunit. These two regions mediate separate anticon convulsant and preconvulsant and preconvulsant effects and use of diverge projection networks. By contrast, in the immature SN there is no special topography of mRNA expression of the α1 subunit and only the preconvulsant network is present. The decreased seizure susceptibility of the mature brain may be related to postnatal segregation of GABAa-sensitive networks.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalBrain research
Volume665
Issue number1
DOIs
Publication statusPublished - Nov 28 1994

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Keywords

  • Deoxyglucose autoradioraphy
  • Hybridization, in situ
  • Infant
  • Rat
  • Receptor subunit
  • Seizure
  • Substantia nigra
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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