Maturation and segregation of brain networks that modify seizures

Solomon L. Moshe, Lucy L. Brown, Hana Kubová, Jana Velíšková, R. Suzanne Zukin, Ellen F. Sperber

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The mature brain is less susceptible to seizures than the immature brain. We demonstrate that in the mature substantia nigra (SN) there are two topographically discrete GABAA-sensitive regions which differ in the amount of mRNA expression of the GABAAa receptor δ1 subunit. These two regions mediate separate anticon convulsant and preconvulsant and preconvulsant effects and use of diverge projection networks. By contrast, in the immature SN there is no special topography of mRNA expression of the α1 subunit and only the preconvulsant network is present. The decreased seizure susceptibility of the mature brain may be related to postnatal segregation of GABAa-sensitive networks.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalBrain Research
Volume665
Issue number1
DOIs
StatePublished - Nov 28 1994

Fingerprint

Seizures
Substantia Nigra
Brain
Convulsants
Messenger RNA

Keywords

  • Deoxyglucose autoradioraphy
  • Hybridization, in situ
  • Infant
  • Rat
  • Receptor subunit
  • Seizure
  • Substantia nigra
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Maturation and segregation of brain networks that modify seizures. / Moshe, Solomon L.; Brown, Lucy L.; Kubová, Hana; Velíšková, Jana; Zukin, R. Suzanne; Sperber, Ellen F.

In: Brain Research, Vol. 665, No. 1, 28.11.1994, p. 141-146.

Research output: Contribution to journalArticle

Moshe, SL, Brown, LL, Kubová, H, Velíšková, J, Zukin, RS & Sperber, EF 1994, 'Maturation and segregation of brain networks that modify seizures', Brain Research, vol. 665, no. 1, pp. 141-146. https://doi.org/10.1016/0006-8993(94)91164-9
Moshe, Solomon L. ; Brown, Lucy L. ; Kubová, Hana ; Velíšková, Jana ; Zukin, R. Suzanne ; Sperber, Ellen F. / Maturation and segregation of brain networks that modify seizures. In: Brain Research. 1994 ; Vol. 665, No. 1. pp. 141-146.
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