Maternofetal transmission of AIDS

Frequency of human immunodeficiency virus type 1 nucleic acid sequences in human fetal DNA

Ruy Soeiro, Arye Rubinstein, William K. Rashbaum, William D. Lyman

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Pediatric AIDS is increasing in frequency due to a rise in the number of human immunodeficiency virus type 1 (HIV-1)-infected women of childbearing age. Because outcome studies reveal that most children infected peripartum manifest HIV-1-related disease in the first year of life, intrauterine infection has been suspected. Fetal tissues from 23 second-trimester abortuses were examined. The presence of HIV-1 nucleic acid sequences was determined by the polymerase chain reaction and used to define infection of the fetus. By analysis of available tissues, 7 of 23 fetuses were infected, while control fetal tissue was negative. In situ hybridization for HIV-1 DNA showed that only 1 of 8 infected abortuses was positive, while all samples of noninfected tissues revealed no HIV-1 DNA. These studies indicate that maternofetal transmission of HIV-1 may occur in 30% of pregnancies (7/23) by the end of the second trimester.

Original languageEnglish (US)
Pages (from-to)699-703
Number of pages5
JournalJournal of Infectious Diseases
Volume166
Issue number4
StatePublished - 1992

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Nucleic Acids
HIV-1
Acquired Immunodeficiency Syndrome
DNA
Fetus
Second Pregnancy Trimester
Peripartum Period
Infection
In Situ Hybridization
Outcome Assessment (Health Care)
Pediatrics
Pregnancy
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Maternofetal transmission of AIDS : Frequency of human immunodeficiency virus type 1 nucleic acid sequences in human fetal DNA. / Soeiro, Ruy; Rubinstein, Arye; Rashbaum, William K.; Lyman, William D.

In: Journal of Infectious Diseases, Vol. 166, No. 4, 1992, p. 699-703.

Research output: Contribution to journalArticle

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