Maternofetal Transmission of AIDS: Frequency of Human Immunodeficiency Virus Type 1 Nucleic Acid Sequences in Human Fetal DNA

Ruy Soeiro, Arye Rubinstein, William K. Rashbaum, William D. Lyman

Research output: Contribution to journalArticle

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Abstract

Pediatric AIDS is increasing in frequency due to a rise in the number of human immunodeficiency virus type 1 (HIV-l)-infected women of childbearing age. Because outcome studies reveal that most children infected peripartum manifest HIV-1-related disease in the first year of life, intrauterine infection has been suspected. Fetal tissues from 23 second-trimester abortuses were examined. The presence of HIV-1 nucleic acid sequences was determined by the polymerase chain reaction and used to define infection of the fetus. By analysis of available tissues, 7 of 23 fetuses were infected, while control fetal tissue was negative. In situ hybridization for HIV-1 DNA showed that only 1 of 8 infected abortuses was positive, while all samples of noninfected tissues revealed no HIV-1 DNA. These studies indicate that maternofetal transmission of HIV-1 may occur in 30% of pregnancies (7/23) by the end of the second trimester.

Original languageEnglish (US)
Pages (from-to)699-703
Number of pages5
JournalJournal of Infectious Diseases
Volume166
Issue number4
DOIs
StatePublished - Oct 1992

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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