Maternal treadmill exercise during pregnancy decreases anxiety and increases prefrontal cortex VEGF and BDNF levels of rat pups in early and late periods of life

Ilkay Aksu, Basak Baykara, Seda Ozbal, Ferihan Cetin, Ali Riza Sisman, Ayfer Dayi, Celal Gencoglu, Aysegul Tas, Erkan Buyuk, Sevil Gonenc-Arda, Nazan Uysal

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In a previous study we demonstrated that, regular aerobic exercise during pregnancy decreased maternal deprivation induced anxiety. The purpose of this study is to investigate whether the positive effects of maternal exercise on the male and female offspring's early and late period of life. Half of the test subjects in each group were evaluated when they were 26. days old, and the other half were evaluated when they were 4. months old. The anxiety levels of maternally exercised groups were less than the control groups in both sexes and in both prepubertal and adult periods. The locomotor activity more increased in females. The prefrontal VEGF and BDNF levels were greater for both age groups and sexes in the maternally exercised group compared to control group. Moreover, there was a strong positive correlations between prefrontal cortex BDNF levels and results of open field tests; and VEGF levels and results of elevated plus maze tests. There was no difference in serum corticosterone levels between groups. These results indicate that maternal exercise during pregnancy may protect the pups from anxiety in early and late periods of life, and affects the prefrontal cortex positively.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalNeuroscience Letters
Volume516
Issue number2
DOIs
StatePublished - May 16 2012

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Brain-Derived Neurotrophic Factor
Prefrontal Cortex
Vascular Endothelial Growth Factor A
Anxiety
Mothers
Exercise
Pregnancy
Maternal Deprivation
Control Groups
Locomotion
Corticosterone
Age Groups
Serum

Keywords

  • Anxiety
  • BDNF
  • Maternal exercise
  • Prefrontal cortex
  • Pups
  • VEGF

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Maternal treadmill exercise during pregnancy decreases anxiety and increases prefrontal cortex VEGF and BDNF levels of rat pups in early and late periods of life. / Aksu, Ilkay; Baykara, Basak; Ozbal, Seda; Cetin, Ferihan; Sisman, Ali Riza; Dayi, Ayfer; Gencoglu, Celal; Tas, Aysegul; Buyuk, Erkan; Gonenc-Arda, Sevil; Uysal, Nazan.

In: Neuroscience Letters, Vol. 516, No. 2, 16.05.2012, p. 221-225.

Research output: Contribution to journalArticle

Aksu, I, Baykara, B, Ozbal, S, Cetin, F, Sisman, AR, Dayi, A, Gencoglu, C, Tas, A, Buyuk, E, Gonenc-Arda, S & Uysal, N 2012, 'Maternal treadmill exercise during pregnancy decreases anxiety and increases prefrontal cortex VEGF and BDNF levels of rat pups in early and late periods of life', Neuroscience Letters, vol. 516, no. 2, pp. 221-225. https://doi.org/10.1016/j.neulet.2012.03.091
Aksu, Ilkay ; Baykara, Basak ; Ozbal, Seda ; Cetin, Ferihan ; Sisman, Ali Riza ; Dayi, Ayfer ; Gencoglu, Celal ; Tas, Aysegul ; Buyuk, Erkan ; Gonenc-Arda, Sevil ; Uysal, Nazan. / Maternal treadmill exercise during pregnancy decreases anxiety and increases prefrontal cortex VEGF and BDNF levels of rat pups in early and late periods of life. In: Neuroscience Letters. 2012 ; Vol. 516, No. 2. pp. 221-225.
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