Maternal Side-Effects After Multiple Courses of Antenatal Corticosteroids (MACS): The Three- Month Follow-Up of Women in the Randomized Controlled Trial of MACS for Preterm Birth Study

Kellie E. Murphy, Mary E. Hannah, Andrew R. Willan, Arne Ohlsson, Edmond N. Kelly, Stephen G. Matthews, Saroj Saigal, Elizabeth Asztalos, Sue Ross, Marie France Delisle, Laura Tomat, Kofi Amankwah, Patricia Guselle, Amiram Gafni, Shoo K. Lee, B. Anthony Armson, Sheila A. Hewson, Joanne Rovet, Renee Sananes, Isabelle SchmidLeonardo Kwiatkowski, Susana Marisa Tortorella, Marta Susana Bertin, José Luis Castaldi, Carlos Deguer, Milton Klun, Cintia Besegato, Gustavo Izbizky, Maria Cristina Vaneri, Carlos Alberto Fustinana, Lucas Otano, Mario S F Palermo, Emerson Javier Murua, Dolores Montes Valera, Hector Sampietro, Antonio Monaco, Argentina Ricardo Savransky, Armando Dunaiewsky, Maria Natalia Basualdo, Elsa Andina, Ingrid Di Marco, Mabel Rivero, Maria Celeste Feu, Sergio Garcia, Jesus Daniel Aguirre, Elba Mirta Morales, Liana Elisa Ayala, Maria Teresa De Sagastizabal, Griselda Abreo, Alfredo Uranga, Raquel de Lourdes Martin, Carlos Arias, Raul Abalos Gorostiaga, Miguel Curioni, Jorge Alvarado, Carlos Fuchtner, Desiree Mostajo Flores, Dilma Maria Tonoli Tessari, Jose Mauro Madi, Dino Roberto Soares de Lorenzi, Maria do Carmo Mattana, Carla Brunstein, Alberto Trapani, Luiza Schmaltz, Goianice Ribero de Souza, Maria Elaine de Assis, Irene Angela Melo Melgaco, Renato Augusto Moreira de Sa, Rita Guerios Bornia, Nestor N. Demianczuk, Elizabeth Penttinen, Kimberly Butt, Kathryn Hay, Vicki Sandwich, Michael Vincer, Victoria Allen, Cora Fanning, Ramesh Kulkarni, Joanne Laplante, George D. Carson, Suzanne Williams, Sandy Holfeld, Femi Olatunbosun, Shirley Dalton, April Henry, Janna Haughian, Jean Marie Moutquin, Daniel Blouin, Suzanne Kocsis Bédard, Kellie Murphy, Edmond Kelly, Anne Jordan, Jodi Shapiro, Jon Barrett, Howard Cohen, Leigh Andrews, Holly Owen, Vesna Popovska, Shelley Soanes, Michael E. Helewa, Doris Kenny-Lodewyks, Ricardo Gomez, Karla Silva, Jorge Figueroa Poblete, Pedro Ferrand, Cristian Belmar, Claudio Vera, Qi Feng Su, Wei Gu, Zhi Wei Liu, Martha Marrugo Flores, Carlos Malabet Santoro, Edgar Ivan Ortiz, Javier Torres, Adriana Rodriguez, Lone Hvidman, Anne Mouritzen, Jennifer Vikre-Jørgensen, Hartmut Hopp, Andreas Nonnenmacher, Ute Braig, Christoph Berg, Gabriele Bizjak, Ulrich Gembruch, Verena Schwarzer, U. B. Hoyme, Hans Jorg Bittrich, Britta Oletzky, Joachim Schneider, Bettina Hollwitz, Katrin Oehler, Frank Dressler, A. Kubilay Ertan, Juliane Hentschel, Annegret Mack, W. Schmidt, Renaldo Faber, Holger Stepan, Maritta Kuhnert, Susanne Stiller, Bettina Kuschel, K. T M Schneider, Andrea Zimmermann, Michael Krause, H. Gröbe, Neslisah Terzioglu, Birgit Seelbach-Goebel, Andreas Falkert, Karin Mueller, Hana Voss, Tamas Major, Krasznai Zoärd, Tünde Bartha, Polonkai Bea, Judit Zsadänyi, Zohar Nachum, Marina Peniakov, Mordechai Hallak, Avraham Harlev, Linda Harel, Benny Chayen, Sima Siev, Ichel Samberg, Leslie Wolff, Oscar Sadan, Anat Elyassi, Carolina Baider, David Kohelet, Abraham Golan, David Mankuta, Benjamin Bar-Oz, Danielle Combs, Doron J D Rosen, Hagai Y. Kaneti, Tal Tzachi, Janice Zausmer, Maor Maman, Tamar Perri, Shani Taitelboum, Michal Simchen, Gilat Shalev, Michael Goldinfeld, Orit Levine, Mazen Y. El-Zibdeh, Lama T. Al-Faris, Hussein A. Ayyash, Pedro Saona Ugarte, Krzysztof Preis, Iwona Domzalska-Popadiuk, Malgorzata Swiatkowska-Freund, Iwona Janczewska, Jan Wilczynski, Michael Krekora, Marcin Kesiak, Ewa Gulczynska, Mariola Ropacka, Mateusz Madejczyk, Joanna Rozycka, Grzegorz H. Breborowicz, Marta Szymankiewicz, Nadezhda Borzova, Lubov V. Posiseeva, Zulfiya Khodjaeva, Ekaterina Vikhlyaeva, Montse Palacio, Dolors Salvia, Francesc Botet, Marta Massanes, Marta Lopez, Irene Hösli, Wolfgang Holzgreve, Cora A. Voekt, Fadhil Belhia, Patrick Hohlfeld, Edmond Prince-dit-Clottu, Ernst Beinder, Ursula von Mandach, Jean Claude Fauchere, Frans J M E Roumen, Mijntje Pieters, Frans Smits, Ibrahim I. Bolaji, Pauline Adiotomre, Hamed Al-Taher, Hayley Barnes, Rezan Abdul-Kadir, Claudia Chi, Vivienne Van Someren, Scott Dexter, Renee Samelson, Michael J. Horgan, Cathryn Valentini, Setul Pardanani, Michael Bebbington, Cynthia Chazotte, Sarah Kilpatrick, Jessica L. Drahos, Luis Saldana, Beverly Mount, Barbara Warner, Kathy Wedig, Andrzej Lysikiewicz, Fadi Bsat, Jennie Fleming, Alison Lee, Despina Hoffman, Michael Bracken, Patricia Crowley, Allan Donner, Lelia Duley, Jon Tyson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: A single course of antenatal corticosteroids (ACS) is associated with a reduction in respiratory distress syndrome and neonatal death. Multiple Courses of Antenatal Corticosteroids Study (MACS), a study involving 1858 women, was a multicentre randomized placebo-controlled trial of multiple courses of ACS, given every 14 days until 33+6 weeks or birth, whichever came first. The primary outcome of the study, a composite of neonatal mortality and morbidity, was similar for the multiple ACS and placebo groups (12.9% vs. 12.5%), but infants exposed to multiple courses of ACS weighed less, were shorter, and had smaller head circumferences. Thus for women who remain at increased risk of preterm birth, multiple courses of ACS (every 14 days) are not recommended. Chronic use of corticosteroids is associated with numerous side effects including weight gain and depression The aim of this postpartum assessment was to ascertain if multiple courses of ACS were associated with maternal side effects. Methods: Three months postpartum, women who participated in MACS were asked to complete a structured questionnaire that asked about maternal side effects of corticosteroid use during MACS and included the Edinburgh Postnatal Depression Scale Women were also asked to evaluate their study participation. Results: Of the 1858 women randomized, 1712 (92.1%) completed the postpartum questionnaire. There were no significant differences in the risk of maternal side effects between the two groups. Large numbers of women met the criteria for postpartum depression (14.1% in the ACS vs. 16.0% in the placebo group). Most women (94.1%) responded that they would participate in the trial again. Conclusion: In pregnancy, corticosteroids are given to women for fetal lung maturation and for the treatment of various maternal diseases. In this international multicentre randomized controlled trial, multiple courses of ACS (every 14 days) were not associated with maternal side effects, and the majority of women responded that they would participate in such a study again.

Original languageEnglish (US)
Pages (from-to)909-921
Number of pages13
JournalJournal of Obstetrics and Gynaecology Canada
Volume33
Issue number9
DOIs
StatePublished - 2011

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Premature Birth
Adrenal Cortex Hormones
Randomized Controlled Trials
Postpartum Period
Postpartum Depression
Placebos
Maternal Inheritance
Infant Mortality
Weight Gain

Keywords

  • Antenatal corticosteroids
  • Postpartum depression
  • Preterm birth
  • Randomized controlled trial

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Maternal Side-Effects After Multiple Courses of Antenatal Corticosteroids (MACS) : The Three- Month Follow-Up of Women in the Randomized Controlled Trial of MACS for Preterm Birth Study. / Murphy, Kellie E.; Hannah, Mary E.; Willan, Andrew R.; Ohlsson, Arne; Kelly, Edmond N.; Matthews, Stephen G.; Saigal, Saroj; Asztalos, Elizabeth; Ross, Sue; Delisle, Marie France; Tomat, Laura; Amankwah, Kofi; Guselle, Patricia; Gafni, Amiram; Lee, Shoo K.; Armson, B. Anthony; Hewson, Sheila A.; Rovet, Joanne; Sananes, Renee; Schmid, Isabelle; Kwiatkowski, Leonardo; Tortorella, Susana Marisa; Bertin, Marta Susana; Castaldi, José Luis; Deguer, Carlos; Klun, Milton; Besegato, Cintia; Izbizky, Gustavo; Vaneri, Maria Cristina; Fustinana, Carlos Alberto; Otano, Lucas; Palermo, Mario S F; Murua, Emerson Javier; Valera, Dolores Montes; Sampietro, Hector; Monaco, Antonio; Savransky, Argentina Ricardo; Dunaiewsky, Armando; Basualdo, Maria Natalia; Andina, Elsa; Di Marco, Ingrid; Rivero, Mabel; Feu, Maria Celeste; Garcia, Sergio; Aguirre, Jesus Daniel; Morales, Elba Mirta; Ayala, Liana Elisa; De Sagastizabal, Maria Teresa; Abreo, Griselda; Uranga, Alfredo; Martin, Raquel de Lourdes; Arias, Carlos; Gorostiaga, Raul Abalos; Curioni, Miguel; Alvarado, Jorge; Fuchtner, Carlos; Flores, Desiree Mostajo; Tonoli Tessari, Dilma Maria; Madi, Jose Mauro; de Lorenzi, Dino Roberto Soares; Mattana, Maria do Carmo; Brunstein, Carla; Trapani, Alberto; Schmaltz, Luiza; de Souza, Goianice Ribero; de Assis, Maria Elaine; Melo Melgaco, Irene Angela; Moreira de Sa, Renato Augusto; Bornia, Rita Guerios; Demianczuk, Nestor N.; Penttinen, Elizabeth; Butt, Kimberly; Hay, Kathryn; Sandwich, Vicki; Vincer, Michael; Allen, Victoria; Fanning, Cora; Kulkarni, Ramesh; Laplante, Joanne; Carson, George D.; Williams, Suzanne; Holfeld, Sandy; Olatunbosun, Femi; Dalton, Shirley; Henry, April; Haughian, Janna; Moutquin, Jean Marie; Blouin, Daniel; Bédard, Suzanne Kocsis; Murphy, Kellie; Kelly, Edmond; Jordan, Anne; Shapiro, Jodi; Barrett, Jon; Cohen, Howard; Andrews, Leigh; Owen, Holly; Popovska, Vesna; Soanes, Shelley; Helewa, Michael E.; Kenny-Lodewyks, Doris; Gomez, Ricardo; Silva, Karla; Poblete, Jorge Figueroa; Ferrand, Pedro; Belmar, Cristian; Vera, Claudio; Su, Qi Feng; Gu, Wei; Liu, Zhi Wei; Flores, Martha Marrugo; Santoro, Carlos Malabet; Ortiz, Edgar Ivan; Torres, Javier; Rodriguez, Adriana; Hvidman, Lone; Mouritzen, Anne; Vikre-Jørgensen, Jennifer; Hopp, Hartmut; Nonnenmacher, Andreas; Braig, Ute; Berg, Christoph; Bizjak, Gabriele; Gembruch, Ulrich; Schwarzer, Verena; Hoyme, U. B.; Bittrich, Hans Jorg; Oletzky, Britta; Schneider, Joachim; Hollwitz, Bettina; Oehler, Katrin; Dressler, Frank; Ertan, A. Kubilay; Hentschel, Juliane; Mack, Annegret; Schmidt, W.; Faber, Renaldo; Stepan, Holger; Kuhnert, Maritta; Stiller, Susanne; Kuschel, Bettina; Schneider, K. T M; Zimmermann, Andrea; Krause, Michael; Gröbe, H.; Terzioglu, Neslisah; Seelbach-Goebel, Birgit; Falkert, Andreas; Mueller, Karin; Voss, Hana; Major, Tamas; Zoärd, Krasznai; Bartha, Tünde; Bea, Polonkai; Zsadänyi, Judit; Nachum, Zohar; Peniakov, Marina; Hallak, Mordechai; Harlev, Avraham; Harel, Linda; Chayen, Benny; Siev, Sima; Samberg, Ichel; Wolff, Leslie; Sadan, Oscar; Elyassi, Anat; Baider, Carolina; Kohelet, David; Golan, Abraham; Mankuta, David; Bar-Oz, Benjamin; Combs, Danielle; Rosen, Doron J D; Kaneti, Hagai Y.; Tzachi, Tal; Zausmer, Janice; Maman, Maor; Perri, Tamar; Taitelboum, Shani; Simchen, Michal; Shalev, Gilat; Goldinfeld, Michael; Levine, Orit; El-Zibdeh, Mazen Y.; Al-Faris, Lama T.; Ayyash, Hussein A.; Ugarte, Pedro Saona; Preis, Krzysztof; Domzalska-Popadiuk, Iwona; Swiatkowska-Freund, Malgorzata; Janczewska, Iwona; Wilczynski, Jan; Krekora, Michael; Kesiak, Marcin; Gulczynska, Ewa; Ropacka, Mariola; Madejczyk, Mateusz; Rozycka, Joanna; Breborowicz, Grzegorz H.; Szymankiewicz, Marta; Borzova, Nadezhda; Posiseeva, Lubov V.; Khodjaeva, Zulfiya; Vikhlyaeva, Ekaterina; Palacio, Montse; Salvia, Dolors; Botet, Francesc; Massanes, Marta; Lopez, Marta; Hösli, Irene; Holzgreve, Wolfgang; Voekt, Cora A.; Belhia, Fadhil; Hohlfeld, Patrick; Prince-dit-Clottu, Edmond; Beinder, Ernst; von Mandach, Ursula; Fauchere, Jean Claude; Roumen, Frans J M E; Pieters, Mijntje; Smits, Frans; Bolaji, Ibrahim I.; Adiotomre, Pauline; Al-Taher, Hamed; Barnes, Hayley; Abdul-Kadir, Rezan; Chi, Claudia; Van Someren, Vivienne; Dexter, Scott; Samelson, Renee; Horgan, Michael J.; Valentini, Cathryn; Pardanani, Setul; Bebbington, Michael; Chazotte, Cynthia; Kilpatrick, Sarah; Drahos, Jessica L.; Saldana, Luis; Mount, Beverly; Warner, Barbara; Wedig, Kathy; Lysikiewicz, Andrzej; Bsat, Fadi; Fleming, Jennie; Lee, Alison; Hoffman, Despina; Bracken, Michael; Crowley, Patricia; Donner, Allan; Duley, Lelia; Tyson, Jon.

In: Journal of Obstetrics and Gynaecology Canada, Vol. 33, No. 9, 2011, p. 909-921.

Research output: Contribution to journalArticle

Murphy, KE, Hannah, ME, Willan, AR, Ohlsson, A, Kelly, EN, Matthews, SG, Saigal, S, Asztalos, E, Ross, S, Delisle, MF, Tomat, L, Amankwah, K, Guselle, P, Gafni, A, Lee, SK, Armson, BA, Hewson, SA, Rovet, J, Sananes, R, Schmid, I, Kwiatkowski, L, Tortorella, SM, Bertin, MS, Castaldi, JL, Deguer, C, Klun, M, Besegato, C, Izbizky, G, Vaneri, MC, Fustinana, CA, Otano, L, Palermo, MSF, Murua, EJ, Valera, DM, Sampietro, H, Monaco, A, Savransky, AR, Dunaiewsky, A, Basualdo, MN, Andina, E, Di Marco, I, Rivero, M, Feu, MC, Garcia, S, Aguirre, JD, Morales, EM, Ayala, LE, De Sagastizabal, MT, Abreo, G, Uranga, A, Martin, RDL, Arias, C, Gorostiaga, RA, Curioni, M, Alvarado, J, Fuchtner, C, Flores, DM, Tonoli Tessari, DM, Madi, JM, de Lorenzi, DRS, Mattana, MDC, Brunstein, C, Trapani, A, Schmaltz, L, de Souza, GR, de Assis, ME, Melo Melgaco, IA, Moreira de Sa, RA, Bornia, RG, Demianczuk, NN, Penttinen, E, Butt, K, Hay, K, Sandwich, V, Vincer, M, Allen, V, Fanning, C, Kulkarni, R, Laplante, J, Carson, GD, Williams, S, Holfeld, S, Olatunbosun, F, Dalton, S, Henry, A, Haughian, J, Moutquin, JM, Blouin, D, Bédard, SK, Murphy, K, Kelly, E, Jordan, A, Shapiro, J, Barrett, J, Cohen, H, Andrews, L, Owen, H, Popovska, V, Soanes, S, Helewa, ME, Kenny-Lodewyks, D, Gomez, R, Silva, K, Poblete, JF, Ferrand, P, Belmar, C, Vera, C, Su, QF, Gu, W, Liu, ZW, Flores, MM, Santoro, CM, Ortiz, EI, Torres, J, Rodriguez, A, Hvidman, L, Mouritzen, A, Vikre-Jørgensen, J, Hopp, H, Nonnenmacher, A, Braig, U, Berg, C, Bizjak, G, Gembruch, U, Schwarzer, V, Hoyme, UB, Bittrich, HJ, Oletzky, B, Schneider, J, Hollwitz, B, Oehler, K, Dressler, F, Ertan, AK, Hentschel, J, Mack, A, Schmidt, W, Faber, R, Stepan, H, Kuhnert, M, Stiller, S, Kuschel, B, Schneider, KTM, Zimmermann, A, Krause, M, Gröbe, H, Terzioglu, N, Seelbach-Goebel, B, Falkert, A, Mueller, K, Voss, H, Major, T, Zoärd, K, Bartha, T, Bea, P, Zsadänyi, J, Nachum, Z, Peniakov, M, Hallak, M, Harlev, A, Harel, L, Chayen, B, Siev, S, Samberg, I, Wolff, L, Sadan, O, Elyassi, A, Baider, C, Kohelet, D, Golan, A, Mankuta, D, Bar-Oz, B, Combs, D, Rosen, DJD, Kaneti, HY, Tzachi, T, Zausmer, J, Maman, M, Perri, T, Taitelboum, S, Simchen, M, Shalev, G, Goldinfeld, M, Levine, O, El-Zibdeh, MY, Al-Faris, LT, Ayyash, HA, Ugarte, PS, Preis, K, Domzalska-Popadiuk, I, Swiatkowska-Freund, M, Janczewska, I, Wilczynski, J, Krekora, M, Kesiak, M, Gulczynska, E, Ropacka, M, Madejczyk, M, Rozycka, J, Breborowicz, GH, Szymankiewicz, M, Borzova, N, Posiseeva, LV, Khodjaeva, Z, Vikhlyaeva, E, Palacio, M, Salvia, D, Botet, F, Massanes, M, Lopez, M, Hösli, I, Holzgreve, W, Voekt, CA, Belhia, F, Hohlfeld, P, Prince-dit-Clottu, E, Beinder, E, von Mandach, U, Fauchere, JC, Roumen, FJME, Pieters, M, Smits, F, Bolaji, II, Adiotomre, P, Al-Taher, H, Barnes, H, Abdul-Kadir, R, Chi, C, Van Someren, V, Dexter, S, Samelson, R, Horgan, MJ, Valentini, C, Pardanani, S, Bebbington, M, Chazotte, C, Kilpatrick, S, Drahos, JL, Saldana, L, Mount, B, Warner, B, Wedig, K, Lysikiewicz, A, Bsat, F, Fleming, J, Lee, A, Hoffman, D, Bracken, M, Crowley, P, Donner, A, Duley, L & Tyson, J 2011, 'Maternal Side-Effects After Multiple Courses of Antenatal Corticosteroids (MACS): The Three- Month Follow-Up of Women in the Randomized Controlled Trial of MACS for Preterm Birth Study', Journal of Obstetrics and Gynaecology Canada, vol. 33, no. 9, pp. 909-921. https://doi.org/10.1016/S1701-2163(16)35016-2
Murphy, Kellie E. ; Hannah, Mary E. ; Willan, Andrew R. ; Ohlsson, Arne ; Kelly, Edmond N. ; Matthews, Stephen G. ; Saigal, Saroj ; Asztalos, Elizabeth ; Ross, Sue ; Delisle, Marie France ; Tomat, Laura ; Amankwah, Kofi ; Guselle, Patricia ; Gafni, Amiram ; Lee, Shoo K. ; Armson, B. Anthony ; Hewson, Sheila A. ; Rovet, Joanne ; Sananes, Renee ; Schmid, Isabelle ; Kwiatkowski, Leonardo ; Tortorella, Susana Marisa ; Bertin, Marta Susana ; Castaldi, José Luis ; Deguer, Carlos ; Klun, Milton ; Besegato, Cintia ; Izbizky, Gustavo ; Vaneri, Maria Cristina ; Fustinana, Carlos Alberto ; Otano, Lucas ; Palermo, Mario S F ; Murua, Emerson Javier ; Valera, Dolores Montes ; Sampietro, Hector ; Monaco, Antonio ; Savransky, Argentina Ricardo ; Dunaiewsky, Armando ; Basualdo, Maria Natalia ; Andina, Elsa ; Di Marco, Ingrid ; Rivero, Mabel ; Feu, Maria Celeste ; Garcia, Sergio ; Aguirre, Jesus Daniel ; Morales, Elba Mirta ; Ayala, Liana Elisa ; De Sagastizabal, Maria Teresa ; Abreo, Griselda ; Uranga, Alfredo ; Martin, Raquel de Lourdes ; Arias, Carlos ; Gorostiaga, Raul Abalos ; Curioni, Miguel ; Alvarado, Jorge ; Fuchtner, Carlos ; Flores, Desiree Mostajo ; Tonoli Tessari, Dilma Maria ; Madi, Jose Mauro ; de Lorenzi, Dino Roberto Soares ; Mattana, Maria do Carmo ; Brunstein, Carla ; Trapani, Alberto ; Schmaltz, Luiza ; de Souza, Goianice Ribero ; de Assis, Maria Elaine ; Melo Melgaco, Irene Angela ; Moreira de Sa, Renato Augusto ; Bornia, Rita Guerios ; Demianczuk, Nestor N. ; Penttinen, Elizabeth ; Butt, Kimberly ; Hay, Kathryn ; Sandwich, Vicki ; Vincer, Michael ; Allen, Victoria ; Fanning, Cora ; Kulkarni, Ramesh ; Laplante, Joanne ; Carson, George D. ; Williams, Suzanne ; Holfeld, Sandy ; Olatunbosun, Femi ; Dalton, Shirley ; Henry, April ; Haughian, Janna ; Moutquin, Jean Marie ; Blouin, Daniel ; Bédard, Suzanne Kocsis ; Murphy, Kellie ; Kelly, Edmond ; Jordan, Anne ; Shapiro, Jodi ; Barrett, Jon ; Cohen, Howard ; Andrews, Leigh ; Owen, Holly ; Popovska, Vesna ; Soanes, Shelley ; Helewa, Michael E. ; Kenny-Lodewyks, Doris ; Gomez, Ricardo ; Silva, Karla ; Poblete, Jorge Figueroa ; Ferrand, Pedro ; Belmar, Cristian ; Vera, Claudio ; Su, Qi Feng ; Gu, Wei ; Liu, Zhi Wei ; Flores, Martha Marrugo ; Santoro, Carlos Malabet ; Ortiz, Edgar Ivan ; Torres, Javier ; Rodriguez, Adriana ; Hvidman, Lone ; Mouritzen, Anne ; Vikre-Jørgensen, Jennifer ; Hopp, Hartmut ; Nonnenmacher, Andreas ; Braig, Ute ; Berg, Christoph ; Bizjak, Gabriele ; Gembruch, Ulrich ; Schwarzer, Verena ; Hoyme, U. B. ; Bittrich, Hans Jorg ; Oletzky, Britta ; Schneider, Joachim ; Hollwitz, Bettina ; Oehler, Katrin ; Dressler, Frank ; Ertan, A. Kubilay ; Hentschel, Juliane ; Mack, Annegret ; Schmidt, W. ; Faber, Renaldo ; Stepan, Holger ; Kuhnert, Maritta ; Stiller, Susanne ; Kuschel, Bettina ; Schneider, K. T M ; Zimmermann, Andrea ; Krause, Michael ; Gröbe, H. ; Terzioglu, Neslisah ; Seelbach-Goebel, Birgit ; Falkert, Andreas ; Mueller, Karin ; Voss, Hana ; Major, Tamas ; Zoärd, Krasznai ; Bartha, Tünde ; Bea, Polonkai ; Zsadänyi, Judit ; Nachum, Zohar ; Peniakov, Marina ; Hallak, Mordechai ; Harlev, Avraham ; Harel, Linda ; Chayen, Benny ; Siev, Sima ; Samberg, Ichel ; Wolff, Leslie ; Sadan, Oscar ; Elyassi, Anat ; Baider, Carolina ; Kohelet, David ; Golan, Abraham ; Mankuta, David ; Bar-Oz, Benjamin ; Combs, Danielle ; Rosen, Doron J D ; Kaneti, Hagai Y. ; Tzachi, Tal ; Zausmer, Janice ; Maman, Maor ; Perri, Tamar ; Taitelboum, Shani ; Simchen, Michal ; Shalev, Gilat ; Goldinfeld, Michael ; Levine, Orit ; El-Zibdeh, Mazen Y. ; Al-Faris, Lama T. ; Ayyash, Hussein A. ; Ugarte, Pedro Saona ; Preis, Krzysztof ; Domzalska-Popadiuk, Iwona ; Swiatkowska-Freund, Malgorzata ; Janczewska, Iwona ; Wilczynski, Jan ; Krekora, Michael ; Kesiak, Marcin ; Gulczynska, Ewa ; Ropacka, Mariola ; Madejczyk, Mateusz ; Rozycka, Joanna ; Breborowicz, Grzegorz H. ; Szymankiewicz, Marta ; Borzova, Nadezhda ; Posiseeva, Lubov V. ; Khodjaeva, Zulfiya ; Vikhlyaeva, Ekaterina ; Palacio, Montse ; Salvia, Dolors ; Botet, Francesc ; Massanes, Marta ; Lopez, Marta ; Hösli, Irene ; Holzgreve, Wolfgang ; Voekt, Cora A. ; Belhia, Fadhil ; Hohlfeld, Patrick ; Prince-dit-Clottu, Edmond ; Beinder, Ernst ; von Mandach, Ursula ; Fauchere, Jean Claude ; Roumen, Frans J M E ; Pieters, Mijntje ; Smits, Frans ; Bolaji, Ibrahim I. ; Adiotomre, Pauline ; Al-Taher, Hamed ; Barnes, Hayley ; Abdul-Kadir, Rezan ; Chi, Claudia ; Van Someren, Vivienne ; Dexter, Scott ; Samelson, Renee ; Horgan, Michael J. ; Valentini, Cathryn ; Pardanani, Setul ; Bebbington, Michael ; Chazotte, Cynthia ; Kilpatrick, Sarah ; Drahos, Jessica L. ; Saldana, Luis ; Mount, Beverly ; Warner, Barbara ; Wedig, Kathy ; Lysikiewicz, Andrzej ; Bsat, Fadi ; Fleming, Jennie ; Lee, Alison ; Hoffman, Despina ; Bracken, Michael ; Crowley, Patricia ; Donner, Allan ; Duley, Lelia ; Tyson, Jon. / Maternal Side-Effects After Multiple Courses of Antenatal Corticosteroids (MACS) : The Three- Month Follow-Up of Women in the Randomized Controlled Trial of MACS for Preterm Birth Study. In: Journal of Obstetrics and Gynaecology Canada. 2011 ; Vol. 33, No. 9. pp. 909-921.
@article{6922f821a6d24349942a64e10d49d929,
title = "Maternal Side-Effects After Multiple Courses of Antenatal Corticosteroids (MACS): The Three- Month Follow-Up of Women in the Randomized Controlled Trial of MACS for Preterm Birth Study",
abstract = "Objective: A single course of antenatal corticosteroids (ACS) is associated with a reduction in respiratory distress syndrome and neonatal death. Multiple Courses of Antenatal Corticosteroids Study (MACS), a study involving 1858 women, was a multicentre randomized placebo-controlled trial of multiple courses of ACS, given every 14 days until 33+6 weeks or birth, whichever came first. The primary outcome of the study, a composite of neonatal mortality and morbidity, was similar for the multiple ACS and placebo groups (12.9{\%} vs. 12.5{\%}), but infants exposed to multiple courses of ACS weighed less, were shorter, and had smaller head circumferences. Thus for women who remain at increased risk of preterm birth, multiple courses of ACS (every 14 days) are not recommended. Chronic use of corticosteroids is associated with numerous side effects including weight gain and depression The aim of this postpartum assessment was to ascertain if multiple courses of ACS were associated with maternal side effects. Methods: Three months postpartum, women who participated in MACS were asked to complete a structured questionnaire that asked about maternal side effects of corticosteroid use during MACS and included the Edinburgh Postnatal Depression Scale Women were also asked to evaluate their study participation. Results: Of the 1858 women randomized, 1712 (92.1{\%}) completed the postpartum questionnaire. There were no significant differences in the risk of maternal side effects between the two groups. Large numbers of women met the criteria for postpartum depression (14.1{\%} in the ACS vs. 16.0{\%} in the placebo group). Most women (94.1{\%}) responded that they would participate in the trial again. Conclusion: In pregnancy, corticosteroids are given to women for fetal lung maturation and for the treatment of various maternal diseases. In this international multicentre randomized controlled trial, multiple courses of ACS (every 14 days) were not associated with maternal side effects, and the majority of women responded that they would participate in such a study again.",
keywords = "Antenatal corticosteroids, Postpartum depression, Preterm birth, Randomized controlled trial",
author = "Murphy, {Kellie E.} and Hannah, {Mary E.} and Willan, {Andrew R.} and Arne Ohlsson and Kelly, {Edmond N.} and Matthews, {Stephen G.} and Saroj Saigal and Elizabeth Asztalos and Sue Ross and Delisle, {Marie France} and Laura Tomat and Kofi Amankwah and Patricia Guselle and Amiram Gafni and Lee, {Shoo K.} and Armson, {B. Anthony} and Hewson, {Sheila A.} and Joanne Rovet and Renee Sananes and Isabelle Schmid and Leonardo Kwiatkowski and Tortorella, {Susana Marisa} and Bertin, {Marta Susana} and Castaldi, {Jos{\'e} Luis} and Carlos Deguer and Milton Klun and Cintia Besegato and Gustavo Izbizky and Vaneri, {Maria Cristina} and Fustinana, {Carlos Alberto} and Lucas Otano and Palermo, {Mario S F} and Murua, {Emerson Javier} and Valera, {Dolores Montes} and Hector Sampietro and Antonio Monaco and Savransky, {Argentina Ricardo} and Armando Dunaiewsky and Basualdo, {Maria Natalia} and Elsa Andina and {Di Marco}, Ingrid and Mabel Rivero and Feu, {Maria Celeste} and Sergio Garcia and Aguirre, {Jesus Daniel} and Morales, {Elba Mirta} and Ayala, {Liana Elisa} and {De Sagastizabal}, {Maria Teresa} and Griselda Abreo and Alfredo Uranga and Martin, {Raquel de Lourdes} and Carlos Arias and Gorostiaga, {Raul Abalos} and Miguel Curioni and Jorge Alvarado and Carlos Fuchtner and Flores, {Desiree Mostajo} and {Tonoli Tessari}, {Dilma Maria} and Madi, {Jose Mauro} and {de Lorenzi}, {Dino Roberto Soares} and Mattana, {Maria do Carmo} and Carla Brunstein and Alberto Trapani and Luiza Schmaltz and {de Souza}, {Goianice Ribero} and {de Assis}, {Maria Elaine} and {Melo Melgaco}, {Irene Angela} and {Moreira de Sa}, {Renato Augusto} and Bornia, {Rita Guerios} and Demianczuk, {Nestor N.} and Elizabeth Penttinen and Kimberly Butt and Kathryn Hay and Vicki Sandwich and Michael Vincer and Victoria Allen and Cora Fanning and Ramesh Kulkarni and Joanne Laplante and Carson, {George D.} and Suzanne Williams and Sandy Holfeld and Femi Olatunbosun and Shirley Dalton and April Henry and Janna Haughian and Moutquin, {Jean Marie} and Daniel Blouin and B{\'e}dard, {Suzanne Kocsis} and Kellie Murphy and Edmond Kelly and Anne Jordan and Jodi Shapiro and Jon Barrett and Howard Cohen and Leigh Andrews and Holly Owen and Vesna Popovska and Shelley Soanes and Helewa, {Michael E.} and Doris Kenny-Lodewyks and Ricardo Gomez and Karla Silva and Poblete, {Jorge Figueroa} and Pedro Ferrand and Cristian Belmar and Claudio Vera and Su, {Qi Feng} and Wei Gu and Liu, {Zhi Wei} and Flores, {Martha Marrugo} and Santoro, {Carlos Malabet} and Ortiz, {Edgar Ivan} and Javier Torres and Adriana Rodriguez and Lone Hvidman and Anne Mouritzen and Jennifer Vikre-J{\o}rgensen and Hartmut Hopp and Andreas Nonnenmacher and Ute Braig and Christoph Berg and Gabriele Bizjak and Ulrich Gembruch and Verena Schwarzer and Hoyme, {U. B.} and Bittrich, {Hans Jorg} and Britta Oletzky and Joachim Schneider and Bettina Hollwitz and Katrin Oehler and Frank Dressler and Ertan, {A. Kubilay} and Juliane Hentschel and Annegret Mack and W. Schmidt and Renaldo Faber and Holger Stepan and Maritta Kuhnert and Susanne Stiller and Bettina Kuschel and Schneider, {K. T M} and Andrea Zimmermann and Michael Krause and H. Gr{\"o}be and Neslisah Terzioglu and Birgit Seelbach-Goebel and Andreas Falkert and Karin Mueller and Hana Voss and Tamas Major and Krasznai Zo{\"a}rd and T{\"u}nde Bartha and Polonkai Bea and Judit Zsad{\"a}nyi and Zohar Nachum and Marina Peniakov and Mordechai Hallak and Avraham Harlev and Linda Harel and Benny Chayen and Sima Siev and Ichel Samberg and Leslie Wolff and Oscar Sadan and Anat Elyassi and Carolina Baider and David Kohelet and Abraham Golan and David Mankuta and Benjamin Bar-Oz and Danielle Combs and Rosen, {Doron J D} and Kaneti, {Hagai Y.} and Tal Tzachi and Janice Zausmer and Maor Maman and Tamar Perri and Shani Taitelboum and Michal Simchen and Gilat Shalev and Michael Goldinfeld and Orit Levine and El-Zibdeh, {Mazen Y.} and Al-Faris, {Lama T.} and Ayyash, {Hussein A.} and Ugarte, {Pedro Saona} and Krzysztof Preis and Iwona Domzalska-Popadiuk and Malgorzata Swiatkowska-Freund and Iwona Janczewska and Jan Wilczynski and Michael Krekora and Marcin Kesiak and Ewa Gulczynska and Mariola Ropacka and Mateusz Madejczyk and Joanna Rozycka and Breborowicz, {Grzegorz H.} and Marta Szymankiewicz and Nadezhda Borzova and Posiseeva, {Lubov V.} and Zulfiya Khodjaeva and Ekaterina Vikhlyaeva and Montse Palacio and Dolors Salvia and Francesc Botet and Marta Massanes and Marta Lopez and Irene H{\"o}sli and Wolfgang Holzgreve and Voekt, {Cora A.} and Fadhil Belhia and Patrick Hohlfeld and Edmond Prince-dit-Clottu and Ernst Beinder and {von Mandach}, Ursula and Fauchere, {Jean Claude} and Roumen, {Frans J M E} and Mijntje Pieters and Frans Smits and Bolaji, {Ibrahim I.} and Pauline Adiotomre and Hamed Al-Taher and Hayley Barnes and Rezan Abdul-Kadir and Claudia Chi and {Van Someren}, Vivienne and Scott Dexter and Renee Samelson and Horgan, {Michael J.} and Cathryn Valentini and Setul Pardanani and Michael Bebbington and Cynthia Chazotte and Sarah Kilpatrick and Drahos, {Jessica L.} and Luis Saldana and Beverly Mount and Barbara Warner and Kathy Wedig and Andrzej Lysikiewicz and Fadi Bsat and Jennie Fleming and Alison Lee and Despina Hoffman and Michael Bracken and Patricia Crowley and Allan Donner and Lelia Duley and Jon Tyson",
year = "2011",
doi = "10.1016/S1701-2163(16)35016-2",
language = "English (US)",
volume = "33",
pages = "909--921",
journal = "Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC",
issn = "1701-2163",
publisher = "Healthcare & Financial Pub.",
number = "9",

}

TY - JOUR

T1 - Maternal Side-Effects After Multiple Courses of Antenatal Corticosteroids (MACS)

T2 - The Three- Month Follow-Up of Women in the Randomized Controlled Trial of MACS for Preterm Birth Study

AU - Murphy, Kellie E.

AU - Hannah, Mary E.

AU - Willan, Andrew R.

AU - Ohlsson, Arne

AU - Kelly, Edmond N.

AU - Matthews, Stephen G.

AU - Saigal, Saroj

AU - Asztalos, Elizabeth

AU - Ross, Sue

AU - Delisle, Marie France

AU - Tomat, Laura

AU - Amankwah, Kofi

AU - Guselle, Patricia

AU - Gafni, Amiram

AU - Lee, Shoo K.

AU - Armson, B. Anthony

AU - Hewson, Sheila A.

AU - Rovet, Joanne

AU - Sananes, Renee

AU - Schmid, Isabelle

AU - Kwiatkowski, Leonardo

AU - Tortorella, Susana Marisa

AU - Bertin, Marta Susana

AU - Castaldi, José Luis

AU - Deguer, Carlos

AU - Klun, Milton

AU - Besegato, Cintia

AU - Izbizky, Gustavo

AU - Vaneri, Maria Cristina

AU - Fustinana, Carlos Alberto

AU - Otano, Lucas

AU - Palermo, Mario S F

AU - Murua, Emerson Javier

AU - Valera, Dolores Montes

AU - Sampietro, Hector

AU - Monaco, Antonio

AU - Savransky, Argentina Ricardo

AU - Dunaiewsky, Armando

AU - Basualdo, Maria Natalia

AU - Andina, Elsa

AU - Di Marco, Ingrid

AU - Rivero, Mabel

AU - Feu, Maria Celeste

AU - Garcia, Sergio

AU - Aguirre, Jesus Daniel

AU - Morales, Elba Mirta

AU - Ayala, Liana Elisa

AU - De Sagastizabal, Maria Teresa

AU - Abreo, Griselda

AU - Uranga, Alfredo

AU - Martin, Raquel de Lourdes

AU - Arias, Carlos

AU - Gorostiaga, Raul Abalos

AU - Curioni, Miguel

AU - Alvarado, Jorge

AU - Fuchtner, Carlos

AU - Flores, Desiree Mostajo

AU - Tonoli Tessari, Dilma Maria

AU - Madi, Jose Mauro

AU - de Lorenzi, Dino Roberto Soares

AU - Mattana, Maria do Carmo

AU - Brunstein, Carla

AU - Trapani, Alberto

AU - Schmaltz, Luiza

AU - de Souza, Goianice Ribero

AU - de Assis, Maria Elaine

AU - Melo Melgaco, Irene Angela

AU - Moreira de Sa, Renato Augusto

AU - Bornia, Rita Guerios

AU - Demianczuk, Nestor N.

AU - Penttinen, Elizabeth

AU - Butt, Kimberly

AU - Hay, Kathryn

AU - Sandwich, Vicki

AU - Vincer, Michael

AU - Allen, Victoria

AU - Fanning, Cora

AU - Kulkarni, Ramesh

AU - Laplante, Joanne

AU - Carson, George D.

AU - Williams, Suzanne

AU - Holfeld, Sandy

AU - Olatunbosun, Femi

AU - Dalton, Shirley

AU - Henry, April

AU - Haughian, Janna

AU - Moutquin, Jean Marie

AU - Blouin, Daniel

AU - Bédard, Suzanne Kocsis

AU - Murphy, Kellie

AU - Kelly, Edmond

AU - Jordan, Anne

AU - Shapiro, Jodi

AU - Barrett, Jon

AU - Cohen, Howard

AU - Andrews, Leigh

AU - Owen, Holly

AU - Popovska, Vesna

AU - Soanes, Shelley

AU - Helewa, Michael E.

AU - Kenny-Lodewyks, Doris

AU - Gomez, Ricardo

AU - Silva, Karla

AU - Poblete, Jorge Figueroa

AU - Ferrand, Pedro

AU - Belmar, Cristian

AU - Vera, Claudio

AU - Su, Qi Feng

AU - Gu, Wei

AU - Liu, Zhi Wei

AU - Flores, Martha Marrugo

AU - Santoro, Carlos Malabet

AU - Ortiz, Edgar Ivan

AU - Torres, Javier

AU - Rodriguez, Adriana

AU - Hvidman, Lone

AU - Mouritzen, Anne

AU - Vikre-Jørgensen, Jennifer

AU - Hopp, Hartmut

AU - Nonnenmacher, Andreas

AU - Braig, Ute

AU - Berg, Christoph

AU - Bizjak, Gabriele

AU - Gembruch, Ulrich

AU - Schwarzer, Verena

AU - Hoyme, U. B.

AU - Bittrich, Hans Jorg

AU - Oletzky, Britta

AU - Schneider, Joachim

AU - Hollwitz, Bettina

AU - Oehler, Katrin

AU - Dressler, Frank

AU - Ertan, A. Kubilay

AU - Hentschel, Juliane

AU - Mack, Annegret

AU - Schmidt, W.

AU - Faber, Renaldo

AU - Stepan, Holger

AU - Kuhnert, Maritta

AU - Stiller, Susanne

AU - Kuschel, Bettina

AU - Schneider, K. T M

AU - Zimmermann, Andrea

AU - Krause, Michael

AU - Gröbe, H.

AU - Terzioglu, Neslisah

AU - Seelbach-Goebel, Birgit

AU - Falkert, Andreas

AU - Mueller, Karin

AU - Voss, Hana

AU - Major, Tamas

AU - Zoärd, Krasznai

AU - Bartha, Tünde

AU - Bea, Polonkai

AU - Zsadänyi, Judit

AU - Nachum, Zohar

AU - Peniakov, Marina

AU - Hallak, Mordechai

AU - Harlev, Avraham

AU - Harel, Linda

AU - Chayen, Benny

AU - Siev, Sima

AU - Samberg, Ichel

AU - Wolff, Leslie

AU - Sadan, Oscar

AU - Elyassi, Anat

AU - Baider, Carolina

AU - Kohelet, David

AU - Golan, Abraham

AU - Mankuta, David

AU - Bar-Oz, Benjamin

AU - Combs, Danielle

AU - Rosen, Doron J D

AU - Kaneti, Hagai Y.

AU - Tzachi, Tal

AU - Zausmer, Janice

AU - Maman, Maor

AU - Perri, Tamar

AU - Taitelboum, Shani

AU - Simchen, Michal

AU - Shalev, Gilat

AU - Goldinfeld, Michael

AU - Levine, Orit

AU - El-Zibdeh, Mazen Y.

AU - Al-Faris, Lama T.

AU - Ayyash, Hussein A.

AU - Ugarte, Pedro Saona

AU - Preis, Krzysztof

AU - Domzalska-Popadiuk, Iwona

AU - Swiatkowska-Freund, Malgorzata

AU - Janczewska, Iwona

AU - Wilczynski, Jan

AU - Krekora, Michael

AU - Kesiak, Marcin

AU - Gulczynska, Ewa

AU - Ropacka, Mariola

AU - Madejczyk, Mateusz

AU - Rozycka, Joanna

AU - Breborowicz, Grzegorz H.

AU - Szymankiewicz, Marta

AU - Borzova, Nadezhda

AU - Posiseeva, Lubov V.

AU - Khodjaeva, Zulfiya

AU - Vikhlyaeva, Ekaterina

AU - Palacio, Montse

AU - Salvia, Dolors

AU - Botet, Francesc

AU - Massanes, Marta

AU - Lopez, Marta

AU - Hösli, Irene

AU - Holzgreve, Wolfgang

AU - Voekt, Cora A.

AU - Belhia, Fadhil

AU - Hohlfeld, Patrick

AU - Prince-dit-Clottu, Edmond

AU - Beinder, Ernst

AU - von Mandach, Ursula

AU - Fauchere, Jean Claude

AU - Roumen, Frans J M E

AU - Pieters, Mijntje

AU - Smits, Frans

AU - Bolaji, Ibrahim I.

AU - Adiotomre, Pauline

AU - Al-Taher, Hamed

AU - Barnes, Hayley

AU - Abdul-Kadir, Rezan

AU - Chi, Claudia

AU - Van Someren, Vivienne

AU - Dexter, Scott

AU - Samelson, Renee

AU - Horgan, Michael J.

AU - Valentini, Cathryn

AU - Pardanani, Setul

AU - Bebbington, Michael

AU - Chazotte, Cynthia

AU - Kilpatrick, Sarah

AU - Drahos, Jessica L.

AU - Saldana, Luis

AU - Mount, Beverly

AU - Warner, Barbara

AU - Wedig, Kathy

AU - Lysikiewicz, Andrzej

AU - Bsat, Fadi

AU - Fleming, Jennie

AU - Lee, Alison

AU - Hoffman, Despina

AU - Bracken, Michael

AU - Crowley, Patricia

AU - Donner, Allan

AU - Duley, Lelia

AU - Tyson, Jon

PY - 2011

Y1 - 2011

N2 - Objective: A single course of antenatal corticosteroids (ACS) is associated with a reduction in respiratory distress syndrome and neonatal death. Multiple Courses of Antenatal Corticosteroids Study (MACS), a study involving 1858 women, was a multicentre randomized placebo-controlled trial of multiple courses of ACS, given every 14 days until 33+6 weeks or birth, whichever came first. The primary outcome of the study, a composite of neonatal mortality and morbidity, was similar for the multiple ACS and placebo groups (12.9% vs. 12.5%), but infants exposed to multiple courses of ACS weighed less, were shorter, and had smaller head circumferences. Thus for women who remain at increased risk of preterm birth, multiple courses of ACS (every 14 days) are not recommended. Chronic use of corticosteroids is associated with numerous side effects including weight gain and depression The aim of this postpartum assessment was to ascertain if multiple courses of ACS were associated with maternal side effects. Methods: Three months postpartum, women who participated in MACS were asked to complete a structured questionnaire that asked about maternal side effects of corticosteroid use during MACS and included the Edinburgh Postnatal Depression Scale Women were also asked to evaluate their study participation. Results: Of the 1858 women randomized, 1712 (92.1%) completed the postpartum questionnaire. There were no significant differences in the risk of maternal side effects between the two groups. Large numbers of women met the criteria for postpartum depression (14.1% in the ACS vs. 16.0% in the placebo group). Most women (94.1%) responded that they would participate in the trial again. Conclusion: In pregnancy, corticosteroids are given to women for fetal lung maturation and for the treatment of various maternal diseases. In this international multicentre randomized controlled trial, multiple courses of ACS (every 14 days) were not associated with maternal side effects, and the majority of women responded that they would participate in such a study again.

AB - Objective: A single course of antenatal corticosteroids (ACS) is associated with a reduction in respiratory distress syndrome and neonatal death. Multiple Courses of Antenatal Corticosteroids Study (MACS), a study involving 1858 women, was a multicentre randomized placebo-controlled trial of multiple courses of ACS, given every 14 days until 33+6 weeks or birth, whichever came first. The primary outcome of the study, a composite of neonatal mortality and morbidity, was similar for the multiple ACS and placebo groups (12.9% vs. 12.5%), but infants exposed to multiple courses of ACS weighed less, were shorter, and had smaller head circumferences. Thus for women who remain at increased risk of preterm birth, multiple courses of ACS (every 14 days) are not recommended. Chronic use of corticosteroids is associated with numerous side effects including weight gain and depression The aim of this postpartum assessment was to ascertain if multiple courses of ACS were associated with maternal side effects. Methods: Three months postpartum, women who participated in MACS were asked to complete a structured questionnaire that asked about maternal side effects of corticosteroid use during MACS and included the Edinburgh Postnatal Depression Scale Women were also asked to evaluate their study participation. Results: Of the 1858 women randomized, 1712 (92.1%) completed the postpartum questionnaire. There were no significant differences in the risk of maternal side effects between the two groups. Large numbers of women met the criteria for postpartum depression (14.1% in the ACS vs. 16.0% in the placebo group). Most women (94.1%) responded that they would participate in the trial again. Conclusion: In pregnancy, corticosteroids are given to women for fetal lung maturation and for the treatment of various maternal diseases. In this international multicentre randomized controlled trial, multiple courses of ACS (every 14 days) were not associated with maternal side effects, and the majority of women responded that they would participate in such a study again.

KW - Antenatal corticosteroids

KW - Postpartum depression

KW - Preterm birth

KW - Randomized controlled trial

UR - http://www.scopus.com/inward/record.url?scp=84867991467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867991467&partnerID=8YFLogxK

U2 - 10.1016/S1701-2163(16)35016-2

DO - 10.1016/S1701-2163(16)35016-2

M3 - Article

C2 - 21923988

AN - SCOPUS:84867991467

VL - 33

SP - 909

EP - 921

JO - Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

JF - Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

SN - 1701-2163

IS - 9

ER -