Maternal risk factors for congenital syphilis

A case-control study

Mayris P. Webber, Genevieve Lambert, David A. Bateman, W. Allen Hauser

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This study estimated the strength of association between maternal cocaine use and congenital syphilis after adjustment for other factors, especially the use of prenatal care. The authors reviewed medical chart and laboratory data for 75 liveborn infants treated for congenital syphilis at Harlem Hospital Center (New York City) in 1987, 150 matched control infants, and their mothers. Cocaine use was determined from universal maternal medical histories and infant toxicology screenings, and the sensitivity of each method of ascertainment was evaluated. With the use of either maternal history or positive infant urine toxicology as evidence of cocaine use, 66.2% (49/74) of case infants versus 16 1% (24/149) of control infants were judged to have been exposed to cocaine in utero (odds ratio (OR) = 91, 95% confidence interval (CI) 4.7-292) However, in multiple logistic regression, lack of prenatal care was the single variable with the highest adjusted odds ratio (adjusted OR = 11.0, 95% CI 1.3-93 1); maternal cocaine use had the second-highest adjusted odds ratio (adjusted OR = 4.9, 95% CI 1.8-13.0). Thus, despite the emergence of maternal cocaine use as a new risk factor, underutilization of prenatal care remains the strongest predictor of congenital syphilis.

Original languageEnglish (US)
Pages (from-to)415-422
Number of pages8
JournalAmerican Journal of Epidemiology
Volume137
Issue number4
StatePublished - Feb 15 1993

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Congenital Syphilis
Cocaine
Case-Control Studies
Mothers
Odds Ratio
Prenatal Care
Confidence Intervals
Toxicology
Logistic Models
Urine

Keywords

  • Cocaine, prenatal care
  • Syphilis, congenital

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Webber, M. P., Lambert, G., Bateman, D. A., & Hauser, W. A. (1993). Maternal risk factors for congenital syphilis: A case-control study. American Journal of Epidemiology, 137(4), 415-422.

Maternal risk factors for congenital syphilis : A case-control study. / Webber, Mayris P.; Lambert, Genevieve; Bateman, David A.; Hauser, W. Allen.

In: American Journal of Epidemiology, Vol. 137, No. 4, 15.02.1993, p. 415-422.

Research output: Contribution to journalArticle

Webber, MP, Lambert, G, Bateman, DA & Hauser, WA 1993, 'Maternal risk factors for congenital syphilis: A case-control study', American Journal of Epidemiology, vol. 137, no. 4, pp. 415-422.
Webber, Mayris P. ; Lambert, Genevieve ; Bateman, David A. ; Hauser, W. Allen. / Maternal risk factors for congenital syphilis : A case-control study. In: American Journal of Epidemiology. 1993 ; Vol. 137, No. 4. pp. 415-422.
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