Maternal perinatal undernutrition modifies lactose and serotranferrin in milk: Relevance to the programming of metabolic diseases?

J. S. Wattez, A. Delmont, M. Bouvet, O. Beseme, S. Goers, Fabien Delahaye, C. Laborie, J. Lesage, B. Foligné, C. Breton, C. C. Metges, D. Vieau, F. Pinet

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A close link between intrauterine growth restriction and development of chronic adult diseases such as obesity, diabetes, and hypertension has been established both in humans and animals. Modification of growth velocity during the early postnatal period (i.e., lactation) may also sensitize to the development of metabolic syndrome in adulthood. This suggests that milk composition may have long-lasting programming/ deprogramming metabolic effects in the offspring. We therefore assess the effects of maternal perinatal denutrition on breast milk composition in a food-restricted 50% (FR50) rat model. Monosaccharides and fatty acids were characterized by gas chromatography, and proteins were profiled by surface-enhanced laser desorption/ionization- time-of-flight analysis in milk samples from FR50 and control rat dams. Milk analysis of FR50 rats demonstrated that maternal undernutrition decreases lactose concentration and modulates lipid profile at postnatal day 10 by increasing the unsaturated fatty acids/saturated fatty acids and diminishes serotransferrin levels at postnatal day 21. Our data indicate that maternal perinatal undernutrition modifies milk composition both quantitatively and qualitatively. These modifications by maternal nutrition open new perspectives to identify molecules that could be used in artificial milk to protect from the subsequent development of metabolic diseases.

Original languageEnglish (US)
Pages (from-to)E393-E401
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume308
Issue number5
DOIs
StatePublished - 2015
Externally publishedYes

Fingerprint

Metabolic Diseases
Lactose
Malnutrition
Milk
Mothers
Fatty Acids
Food Analysis
Food
Monosaccharides
Human Milk
Transferrin
Unsaturated Fatty Acids
Growth and Development
Lactation
Gas Chromatography
Lasers
Chronic Disease
Obesity
Hypertension
Lipids

Keywords

  • Carbohydrates
  • Fatty acids
  • Mass spectrometry
  • Nutrition
  • Rat

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Maternal perinatal undernutrition modifies lactose and serotranferrin in milk : Relevance to the programming of metabolic diseases? / Wattez, J. S.; Delmont, A.; Bouvet, M.; Beseme, O.; Goers, S.; Delahaye, Fabien; Laborie, C.; Lesage, J.; Foligné, B.; Breton, C.; Metges, C. C.; Vieau, D.; Pinet, F.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 308, No. 5, 2015, p. E393-E401.

Research output: Contribution to journalArticle

Wattez, JS, Delmont, A, Bouvet, M, Beseme, O, Goers, S, Delahaye, F, Laborie, C, Lesage, J, Foligné, B, Breton, C, Metges, CC, Vieau, D & Pinet, F 2015, 'Maternal perinatal undernutrition modifies lactose and serotranferrin in milk: Relevance to the programming of metabolic diseases?', American Journal of Physiology - Endocrinology and Metabolism, vol. 308, no. 5, pp. E393-E401. https://doi.org/10.1152/ajpendo.00452.2014
Wattez, J. S. ; Delmont, A. ; Bouvet, M. ; Beseme, O. ; Goers, S. ; Delahaye, Fabien ; Laborie, C. ; Lesage, J. ; Foligné, B. ; Breton, C. ; Metges, C. C. ; Vieau, D. ; Pinet, F. / Maternal perinatal undernutrition modifies lactose and serotranferrin in milk : Relevance to the programming of metabolic diseases?. In: American Journal of Physiology - Endocrinology and Metabolism. 2015 ; Vol. 308, No. 5. pp. E393-E401.
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