Maternal microchimerism: Friend or foe in type 1 diabetes?

Jody Ye; Marta Vives-Pi; Kathleen M. Gillespie

doi:10.4161/chim.29870

Maternal microchimerism: Friend or foe in type 1 diabetes?

Jody Ye, Marta Vives-Pi, Kathleen M. Gillespie

Research output: Contribution to journal › Comment/debate › peer-review

6 Scopus citations

Abstract

Increased levels of non-inherited maternal HLA alleles have been detected in the periphery of children with type 1 diabetes and an increased frequency of maternal cells have been identified in type 1 diabetes pancreas. It is now clear that the phenotype of these cells is pancreatic,1 supporting the hypothesis that maternal cells in human pancreas are derived from multipotent maternal progenitors. Here we hypothesize how increased levels of maternal cells could play a role in islet autoimmunity.

Original language	English (US)
Journal	Chimerism
Volume	5
Issue number	2
DOIs	https://doi.org/10.4161/chim.29870
State	Published - Aug 5 2014
Externally published	Yes

Keywords

Maternal microchimerism
Type 1 diabetes

ASJC Scopus subject areas

Biochemistry
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Molecular Biology
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4161/chim.29870

Cite this

@article{7508e8c1658f4844a8e6ba0e9eff6d09,

title = "Maternal microchimerism: Friend or foe in type 1 diabetes?",

abstract = "Increased levels of non-inherited maternal HLA alleles have been detected in the periphery of children with type 1 diabetes and an increased frequency of maternal cells have been identified in type 1 diabetes pancreas. It is now clear that the phenotype of these cells is pancreatic,1 supporting the hypothesis that maternal cells in human pancreas are derived from multipotent maternal progenitors. Here we hypothesize how increased levels of maternal cells could play a role in islet autoimmunity.",

keywords = "Maternal microchimerism, Type 1 diabetes",

author = "Jody Ye and Marta Vives-Pi and Gillespie, {Kathleen M.}",

note = "Funding Information: JY was funded by a Diabetes UK PhD scholarship (ref # 07/0003562) and Diabetes UK project grant to KMG (ref# 12/0004564).",

year = "2014",

month = aug,

day = "5",

doi = "10.4161/chim.29870",

language = "English (US)",

volume = "5",

journal = "Chimerism",

issn = "1938-1956",

publisher = "Landes Bioscience",

number = "2",

}

TY - JOUR

T1 - Maternal microchimerism

T2 - Friend or foe in type 1 diabetes?

AU - Ye, Jody

AU - Vives-Pi, Marta

AU - Gillespie, Kathleen M.

N1 - Funding Information: JY was funded by a Diabetes UK PhD scholarship (ref # 07/0003562) and Diabetes UK project grant to KMG (ref# 12/0004564).

PY - 2014/8/5

Y1 - 2014/8/5

N2 - Increased levels of non-inherited maternal HLA alleles have been detected in the periphery of children with type 1 diabetes and an increased frequency of maternal cells have been identified in type 1 diabetes pancreas. It is now clear that the phenotype of these cells is pancreatic,1 supporting the hypothesis that maternal cells in human pancreas are derived from multipotent maternal progenitors. Here we hypothesize how increased levels of maternal cells could play a role in islet autoimmunity.

AB - Increased levels of non-inherited maternal HLA alleles have been detected in the periphery of children with type 1 diabetes and an increased frequency of maternal cells have been identified in type 1 diabetes pancreas. It is now clear that the phenotype of these cells is pancreatic,1 supporting the hypothesis that maternal cells in human pancreas are derived from multipotent maternal progenitors. Here we hypothesize how increased levels of maternal cells could play a role in islet autoimmunity.

KW - Maternal microchimerism

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=84926259260&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926259260&partnerID=8YFLogxK

U2 - 10.4161/chim.29870

DO - 10.4161/chim.29870

M3 - Comment/debate

C2 - 25093746

AN - SCOPUS:84926259260

SN - 1938-1956

VL - 5

JO - Chimerism

JF - Chimerism

IS - 2

ER -

Maternal microchimerism: Friend or foe in type 1 diabetes?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this