Maternal microchimerism: Friend or foe in type 1 diabetes?

Jody Ye, Marta Vives-Pi, Kathleen M. Gillespie

Research output: Contribution to journalComment/debatepeer-review

3 Scopus citations

Abstract

Increased levels of non-inherited maternal HLA alleles have been detected in the periphery of children with type 1 diabetes and an increased frequency of maternal cells have been identified in type 1 diabetes pancreas. It is now clear that the phenotype of these cells is pancreatic,1 supporting the hypothesis that maternal cells in human pancreas are derived from multipotent maternal progenitors. Here we hypothesize how increased levels of maternal cells could play a role in islet autoimmunity.

Original languageEnglish (US)
JournalChimerism
Volume5
Issue number2
DOIs
StatePublished - Aug 5 2014
Externally publishedYes

Keywords

  • Maternal microchimerism
  • Type 1 diabetes

ASJC Scopus subject areas

  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Molecular Biology
  • Genetics

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