Maternal BMI and preterm birth: A systematic review of the literature with meta-analysis

Maria Regina Torloni, Ana Pilar Betrán, Silvia Daher, Mariana Widmer, Siobhan M. Dolan, Ramkumar Menon, Eduardo Bergel, Tomas Allen, Mario Merialdi

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Objectives.To examine the association between high prepregnancy maternal body mass index BMI and the risk of preterm birth PTB. Methods.A systematic review of the literature. We included cohorts and case-control studies published since 1968 that examined the association between BMI and PTB of all types, spontaneous (s), elective and with ruptured membranes (PPROM) in three gestational age categories: general (<37 weeks), moderate (32-36 weeks) and very (<32 weeks) PTB. Results.20,401 citations were screened and 39 studies (1,788,633 women) were included. Preobese (BMI, 25-29.9) and obese I (BMI, 3034.9) women have a reduced risk for sPTB: AOR 0.85 (95% CI: 0.80-0.92) and 0.83 (95% CI: 0.75-0.92), respectively. Their risk for moderate PTB was 1.20 (95% CI: 1.04-1.38) and 1.60 (95% CI: 1.32-1.94), respectively. Obese II women (BMI, 35-40) have an increased risk for PTB in general (AOR=1.33, 95% CI: 1.12-1.57) moderate (AOR=2.43, 95% CI: 1.46-4.05) and very PTB (AOR=1.96, 95% CI: 1.66-2.31). Obese III women (BMI > 40) have an even higher risk for very PTB (AOR=2.27, 95CI: 1.762.94). High BMI does not modify the risk for PPROM and increases the risk for elective PTB. Conclusions.High maternal BMI may have different effects on different types of PTB.

Original languageEnglish (US)
Pages (from-to)957-970
Number of pages14
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume22
Issue number11
DOIs
StatePublished - Nov 2009

Fingerprint

Premature Birth
Meta-Analysis
Mothers
Gestational Age
Case-Control Studies
Body Mass Index
Membranes
Preterm Premature Rupture of the Membranes

Keywords

  • Adiposity
  • Body mass index
  • Literature review
  • Meta-analysis
  • Obesity
  • Overweight
  • Premature birth
  • Preterm labor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Maternal BMI and preterm birth : A systematic review of the literature with meta-analysis. / Torloni, Maria Regina; Betrán, Ana Pilar; Daher, Silvia; Widmer, Mariana; Dolan, Siobhan M.; Menon, Ramkumar; Bergel, Eduardo; Allen, Tomas; Merialdi, Mario.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 22, No. 11, 11.2009, p. 957-970.

Research output: Contribution to journalArticle

Torloni, MR, Betrán, AP, Daher, S, Widmer, M, Dolan, SM, Menon, R, Bergel, E, Allen, T & Merialdi, M 2009, 'Maternal BMI and preterm birth: A systematic review of the literature with meta-analysis', Journal of Maternal-Fetal and Neonatal Medicine, vol. 22, no. 11, pp. 957-970. https://doi.org/10.3109/14767050903042561
Torloni, Maria Regina ; Betrán, Ana Pilar ; Daher, Silvia ; Widmer, Mariana ; Dolan, Siobhan M. ; Menon, Ramkumar ; Bergel, Eduardo ; Allen, Tomas ; Merialdi, Mario. / Maternal BMI and preterm birth : A systematic review of the literature with meta-analysis. In: Journal of Maternal-Fetal and Neonatal Medicine. 2009 ; Vol. 22, No. 11. pp. 957-970.
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abstract = "Objectives.To examine the association between high prepregnancy maternal body mass index BMI and the risk of preterm birth PTB. Methods.A systematic review of the literature. We included cohorts and case-control studies published since 1968 that examined the association between BMI and PTB of all types, spontaneous (s), elective and with ruptured membranes (PPROM) in three gestational age categories: general (<37 weeks), moderate (32-36 weeks) and very (<32 weeks) PTB. Results.20,401 citations were screened and 39 studies (1,788,633 women) were included. Preobese (BMI, 25-29.9) and obese I (BMI, 3034.9) women have a reduced risk for sPTB: AOR 0.85 (95{\%} CI: 0.80-0.92) and 0.83 (95{\%} CI: 0.75-0.92), respectively. Their risk for moderate PTB was 1.20 (95{\%} CI: 1.04-1.38) and 1.60 (95{\%} CI: 1.32-1.94), respectively. Obese II women (BMI, 35-40) have an increased risk for PTB in general (AOR=1.33, 95{\%} CI: 1.12-1.57) moderate (AOR=2.43, 95{\%} CI: 1.46-4.05) and very PTB (AOR=1.96, 95{\%} CI: 1.66-2.31). Obese III women (BMI > 40) have an even higher risk for very PTB (AOR=2.27, 95CI: 1.762.94). High BMI does not modify the risk for PPROM and increases the risk for elective PTB. Conclusions.High maternal BMI may have different effects on different types of PTB.",
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AU - Torloni, Maria Regina

AU - Betrán, Ana Pilar

AU - Daher, Silvia

AU - Widmer, Mariana

AU - Dolan, Siobhan M.

AU - Menon, Ramkumar

AU - Bergel, Eduardo

AU - Allen, Tomas

AU - Merialdi, Mario

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AB - Objectives.To examine the association between high prepregnancy maternal body mass index BMI and the risk of preterm birth PTB. Methods.A systematic review of the literature. We included cohorts and case-control studies published since 1968 that examined the association between BMI and PTB of all types, spontaneous (s), elective and with ruptured membranes (PPROM) in three gestational age categories: general (<37 weeks), moderate (32-36 weeks) and very (<32 weeks) PTB. Results.20,401 citations were screened and 39 studies (1,788,633 women) were included. Preobese (BMI, 25-29.9) and obese I (BMI, 3034.9) women have a reduced risk for sPTB: AOR 0.85 (95% CI: 0.80-0.92) and 0.83 (95% CI: 0.75-0.92), respectively. Their risk for moderate PTB was 1.20 (95% CI: 1.04-1.38) and 1.60 (95% CI: 1.32-1.94), respectively. Obese II women (BMI, 35-40) have an increased risk for PTB in general (AOR=1.33, 95% CI: 1.12-1.57) moderate (AOR=2.43, 95% CI: 1.46-4.05) and very PTB (AOR=1.96, 95% CI: 1.66-2.31). Obese III women (BMI > 40) have an even higher risk for very PTB (AOR=2.27, 95CI: 1.762.94). High BMI does not modify the risk for PPROM and increases the risk for elective PTB. Conclusions.High maternal BMI may have different effects on different types of PTB.

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KW - Body mass index

KW - Literature review

KW - Meta-analysis

KW - Obesity

KW - Overweight

KW - Premature birth

KW - Preterm labor

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