Maternal adherence to the zidovudine regimen for HIV-exposed infants to prevent HIV infection: a preliminary study.

Penelope A. Demas, Mayris P. Webber, Ellie Schoenbaum, Jeremy Weedon, Janis McWayne, Elizabeth Enriquez, Mahrukh Bamji, Genevieve Lambert, Donald M. Thea

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

OBJECTIVE: To describe the extent of adherence to the recommended neonatal zidovudine (ZDV) regimen administered to infants who have been exposed to the human immunodeficiency virus (HIV) to prevent mother-to-child transmission of HIV and to determine which maternal factors are associated with compliance. METHODS: HIV-infected women (n = 87) who were participating in a larger study of perinatal transmission at 3 inner-city New York City hospitals were interviewed 2 to 6 weeks' postpartum to assess adherence to neonatal prophylaxis, social support, social network factors, and depression. In addition, plasma samples of 45 of their infants were assayed for ZDV levels. RESULTS: A majority of women (71%) administered all of the prescribed 4 daily doses in the previous week, as measured by interview; self-reported adherence was not associated with any maternal characteristics. In contrast, poor adherence, as measured by lower infant ZDV plasma levels, was associated with asymptomatic HIV illness in the mother and having 2 or more other children; good adherence, as indicated by higher ZDV levels, was associated with the presence of a maternal social support network, disclosure of HIV infection, and mothers' adherence to their own ZDV regimens during pregnancy. In multivariate regression analyses, maternal asymptomatic status (beta = -0.40) was associated with lower infant ZDV levels, and maternal adherence during pregnancy (beta = 0.37) was associated with higher levels. CONCLUSIONS: Women who are HIV asymptomatic and lack a social support network are more likely not to comply with the recommended neonatal prophylactic regimen of antiretroviral therapy. Future studies should address the prenatal period and social network factors, such as disclosure of serostatus, and the custody of other children.

Original languageEnglish (US)
JournalPediatrics
Volume110
Issue number3
StatePublished - Sep 2002

Fingerprint

Zidovudine
Virus Diseases
Social Support
Mothers
HIV
Disclosure
Child Custody
Pregnancy
Urban Hospitals
Postpartum Period
Compliance
Multivariate Analysis
Regression Analysis
Interviews
Depression

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Maternal adherence to the zidovudine regimen for HIV-exposed infants to prevent HIV infection : a preliminary study. / Demas, Penelope A.; Webber, Mayris P.; Schoenbaum, Ellie; Weedon, Jeremy; McWayne, Janis; Enriquez, Elizabeth; Bamji, Mahrukh; Lambert, Genevieve; Thea, Donald M.

In: Pediatrics, Vol. 110, No. 3, 09.2002.

Research output: Contribution to journalArticle

Demas, PA, Webber, MP, Schoenbaum, E, Weedon, J, McWayne, J, Enriquez, E, Bamji, M, Lambert, G & Thea, DM 2002, 'Maternal adherence to the zidovudine regimen for HIV-exposed infants to prevent HIV infection: a preliminary study.', Pediatrics, vol. 110, no. 3.
Demas, Penelope A. ; Webber, Mayris P. ; Schoenbaum, Ellie ; Weedon, Jeremy ; McWayne, Janis ; Enriquez, Elizabeth ; Bamji, Mahrukh ; Lambert, Genevieve ; Thea, Donald M. / Maternal adherence to the zidovudine regimen for HIV-exposed infants to prevent HIV infection : a preliminary study. In: Pediatrics. 2002 ; Vol. 110, No. 3.
@article{5244073c60d145c78ae8671cffa958a2,
title = "Maternal adherence to the zidovudine regimen for HIV-exposed infants to prevent HIV infection: a preliminary study.",
abstract = "OBJECTIVE: To describe the extent of adherence to the recommended neonatal zidovudine (ZDV) regimen administered to infants who have been exposed to the human immunodeficiency virus (HIV) to prevent mother-to-child transmission of HIV and to determine which maternal factors are associated with compliance. METHODS: HIV-infected women (n = 87) who were participating in a larger study of perinatal transmission at 3 inner-city New York City hospitals were interviewed 2 to 6 weeks' postpartum to assess adherence to neonatal prophylaxis, social support, social network factors, and depression. In addition, plasma samples of 45 of their infants were assayed for ZDV levels. RESULTS: A majority of women (71{\%}) administered all of the prescribed 4 daily doses in the previous week, as measured by interview; self-reported adherence was not associated with any maternal characteristics. In contrast, poor adherence, as measured by lower infant ZDV plasma levels, was associated with asymptomatic HIV illness in the mother and having 2 or more other children; good adherence, as indicated by higher ZDV levels, was associated with the presence of a maternal social support network, disclosure of HIV infection, and mothers' adherence to their own ZDV regimens during pregnancy. In multivariate regression analyses, maternal asymptomatic status (beta = -0.40) was associated with lower infant ZDV levels, and maternal adherence during pregnancy (beta = 0.37) was associated with higher levels. CONCLUSIONS: Women who are HIV asymptomatic and lack a social support network are more likely not to comply with the recommended neonatal prophylactic regimen of antiretroviral therapy. Future studies should address the prenatal period and social network factors, such as disclosure of serostatus, and the custody of other children.",
author = "Demas, {Penelope A.} and Webber, {Mayris P.} and Ellie Schoenbaum and Jeremy Weedon and Janis McWayne and Elizabeth Enriquez and Mahrukh Bamji and Genevieve Lambert and Thea, {Donald M.}",
year = "2002",
month = "9",
language = "English (US)",
volume = "110",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "3",

}

TY - JOUR

T1 - Maternal adherence to the zidovudine regimen for HIV-exposed infants to prevent HIV infection

T2 - a preliminary study.

AU - Demas, Penelope A.

AU - Webber, Mayris P.

AU - Schoenbaum, Ellie

AU - Weedon, Jeremy

AU - McWayne, Janis

AU - Enriquez, Elizabeth

AU - Bamji, Mahrukh

AU - Lambert, Genevieve

AU - Thea, Donald M.

PY - 2002/9

Y1 - 2002/9

N2 - OBJECTIVE: To describe the extent of adherence to the recommended neonatal zidovudine (ZDV) regimen administered to infants who have been exposed to the human immunodeficiency virus (HIV) to prevent mother-to-child transmission of HIV and to determine which maternal factors are associated with compliance. METHODS: HIV-infected women (n = 87) who were participating in a larger study of perinatal transmission at 3 inner-city New York City hospitals were interviewed 2 to 6 weeks' postpartum to assess adherence to neonatal prophylaxis, social support, social network factors, and depression. In addition, plasma samples of 45 of their infants were assayed for ZDV levels. RESULTS: A majority of women (71%) administered all of the prescribed 4 daily doses in the previous week, as measured by interview; self-reported adherence was not associated with any maternal characteristics. In contrast, poor adherence, as measured by lower infant ZDV plasma levels, was associated with asymptomatic HIV illness in the mother and having 2 or more other children; good adherence, as indicated by higher ZDV levels, was associated with the presence of a maternal social support network, disclosure of HIV infection, and mothers' adherence to their own ZDV regimens during pregnancy. In multivariate regression analyses, maternal asymptomatic status (beta = -0.40) was associated with lower infant ZDV levels, and maternal adherence during pregnancy (beta = 0.37) was associated with higher levels. CONCLUSIONS: Women who are HIV asymptomatic and lack a social support network are more likely not to comply with the recommended neonatal prophylactic regimen of antiretroviral therapy. Future studies should address the prenatal period and social network factors, such as disclosure of serostatus, and the custody of other children.

AB - OBJECTIVE: To describe the extent of adherence to the recommended neonatal zidovudine (ZDV) regimen administered to infants who have been exposed to the human immunodeficiency virus (HIV) to prevent mother-to-child transmission of HIV and to determine which maternal factors are associated with compliance. METHODS: HIV-infected women (n = 87) who were participating in a larger study of perinatal transmission at 3 inner-city New York City hospitals were interviewed 2 to 6 weeks' postpartum to assess adherence to neonatal prophylaxis, social support, social network factors, and depression. In addition, plasma samples of 45 of their infants were assayed for ZDV levels. RESULTS: A majority of women (71%) administered all of the prescribed 4 daily doses in the previous week, as measured by interview; self-reported adherence was not associated with any maternal characteristics. In contrast, poor adherence, as measured by lower infant ZDV plasma levels, was associated with asymptomatic HIV illness in the mother and having 2 or more other children; good adherence, as indicated by higher ZDV levels, was associated with the presence of a maternal social support network, disclosure of HIV infection, and mothers' adherence to their own ZDV regimens during pregnancy. In multivariate regression analyses, maternal asymptomatic status (beta = -0.40) was associated with lower infant ZDV levels, and maternal adherence during pregnancy (beta = 0.37) was associated with higher levels. CONCLUSIONS: Women who are HIV asymptomatic and lack a social support network are more likely not to comply with the recommended neonatal prophylactic regimen of antiretroviral therapy. Future studies should address the prenatal period and social network factors, such as disclosure of serostatus, and the custody of other children.

UR - http://www.scopus.com/inward/record.url?scp=18244416295&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18244416295&partnerID=8YFLogxK

M3 - Article

C2 - 12205285

AN - SCOPUS:18244416295

VL - 110

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 3

ER -