Markers of health status in an HTLV-I-positive cohort

Gloria Y F Ho, Kenrad Nelson, Abraham M Y Nomura, B. Frank Polk, William A. Blattner

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The health effects of chronic human T-cell lymphotropic virus type I (HTLV-I) infection were examined in a cohort of Japanese men who had emigrated from Okinawa, Japan, and had been participants in a prospective study in Hawaii since 1965. In the present follow-up study carried out in 1987-1988, various health indicators were measured in the subjects, whose mean age was 72.5 years. Participation rates were lower in the HTLV-I seropositives than in the seronegatives (46.7% vs. 76.0%) in the ≥75-year age group. Lack of participation was significantly correlated with a high HTLV-I antibody titer. Among the participants, seropositive subjects were significantly more likely than the seronegatives to have lymphocytopenia (32.7% vs. 17.7%) and mild anemia (25.5% vs. 14.1%) after adjustment for age and socioeconomic status. The seropositives also had a higher frequency of acupuncture therapy (age-adjusted odds ratios were 2.1 and 4.2 for 1-5 treatments and ≥6 treatments, respectively). Proportions of subjects who had been hospitalized at least twice were higher among the seropositives in the oldest age groups, 70-74 years and ≥75 years, but not in those aged 65-69 years. Although specific disease conditions were not identified in this study, hematologic data, treatment histories, and the correlation between participation status and HTLV-I antibody titers suggest that chronic HTLV-I infection may be associated with as yet undefined adverse health effects, particularly in older age groups. Am J Epidemiol 1992; 136: 1349-57.

Original languageEnglish (US)
Pages (from-to)1349-1357
Number of pages9
JournalAmerican Journal of Epidemiology
Volume136
Issue number11
StatePublished - Dec 1 1992
Externally publishedYes

Fingerprint

Health Status
Viruses
T-Lymphocytes
Age Groups
Virus Diseases
Health
Acupuncture Therapy
Lymphopenia
Antibodies
Social Class
Anemia
Japan
Therapeutics
Odds Ratio
Prospective Studies

Keywords

  • Acupuncture
  • HTLV-I
  • Lymphocytes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Ho, G. Y. F., Nelson, K., Nomura, A. M. Y., Polk, B. F., & Blattner, W. A. (1992). Markers of health status in an HTLV-I-positive cohort. American Journal of Epidemiology, 136(11), 1349-1357.

Markers of health status in an HTLV-I-positive cohort. / Ho, Gloria Y F; Nelson, Kenrad; Nomura, Abraham M Y; Polk, B. Frank; Blattner, William A.

In: American Journal of Epidemiology, Vol. 136, No. 11, 01.12.1992, p. 1349-1357.

Research output: Contribution to journalArticle

Ho, GYF, Nelson, K, Nomura, AMY, Polk, BF & Blattner, WA 1992, 'Markers of health status in an HTLV-I-positive cohort', American Journal of Epidemiology, vol. 136, no. 11, pp. 1349-1357.
Ho GYF, Nelson K, Nomura AMY, Polk BF, Blattner WA. Markers of health status in an HTLV-I-positive cohort. American Journal of Epidemiology. 1992 Dec 1;136(11):1349-1357.
Ho, Gloria Y F ; Nelson, Kenrad ; Nomura, Abraham M Y ; Polk, B. Frank ; Blattner, William A. / Markers of health status in an HTLV-I-positive cohort. In: American Journal of Epidemiology. 1992 ; Vol. 136, No. 11. pp. 1349-1357.
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