Abstract
Breast cancer is the most prevalent invasive form of cancer in females and posing a great challenge for overcoming disease burden. The growth in global cancer deaths mandates the discovery of new efficacious natural anti-tumor treatments. In this regard, aquatic species offer a rich supply of possible drugs. Studies have shown that several marine peptides damage cancer cells by a broad range of pathways, including apoptosis, microtubule balance disturbances, and suppression of angiogenesis. Traditional chemotherapeutic agents are characterized by a plethora of side effects, including immune response suppression. The discovery of novel putative anti-cancer peptides with lesser toxicity is therefore necessary and timely, especially those able to thwart multi drug resistance (MDR). This review addresses marine anti-cancer peptides for the treatment of breast cancer.
Original language | English (US) |
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Article number | 112038 |
Journal | Biomedicine and Pharmacotherapy |
Volume | 142 |
DOIs | |
State | Published - Oct 2021 |
Keywords
- Apoptosis
- Cell cycle arrest
- Marine peptides
- Metastasis
- Protein hydrolysate
ASJC Scopus subject areas
- Pharmacology