Mapping of the structural gene for the second component of complement with respect to the human major histocompatibility complex

Donald Douglas Raum, D. Glass, C. B. Carpenter, P. H. Schur, C. A. Alper

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Families have been HLA typed, and allotypes of the second component of complement and properdin factor B determined. The lod score for the C2 structural gene and HLA-B from the study of 11 families and 55 informative meisoses was 14.39 at maximum likelihood estimate of the recombination fraction of .02. This is related to other estimates of the distance between these two genes. The relative kinetic activities of the C2 allotypes were studied and no differences were demonstrated. No crossovers between Bf and C2 were observed.

Original languageEnglish (US)
Pages (from-to)35-41
Number of pages7
JournalAmerican Journal of Human Genetics
Volume31
Issue number1
StatePublished - 1979
Externally publishedYes

Fingerprint

Gene Components
Complement Factor B
Major Histocompatibility Complex
Lod Score
Likelihood Functions
HLA-B Antigens
Genetic Recombination
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Mapping of the structural gene for the second component of complement with respect to the human major histocompatibility complex. / Raum, Donald Douglas; Glass, D.; Carpenter, C. B.; Schur, P. H.; Alper, C. A.

In: American Journal of Human Genetics, Vol. 31, No. 1, 1979, p. 35-41.

Research output: Contribution to journalArticle

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