Manipulation of Fgf and Bmp signaling in teleost fishes suggests potential pathways for the evolutionary origin of multicuspid teeth

William R. Jackman, Shelby H. Davies, David B. Lyons, Caitlin K. Stauder, Benjamin R. Denton-Schneider, Andrea Jowdry, Sharon R. Aigler, Scott A. Vogel, David W. Stock

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Teeth with two or more cusps have arisen independently from an ancestral unicuspid condition in a variety of vertebrate lineages, including sharks, teleost fishes, amphibians, lizards, and mammals. One potential explanation for the repeated origins of multicuspid teeth is the existence of multiple adaptive pathways leading to them, as suggested by their different uses in these lineages. Another is that the addition of cusps required only minor changes in genetic pathways regulating tooth development. Here we provide support for the latter hypothesis by demonstrating that manipulation of the levels of Fibroblast growth factor (Fgf) or Bone morphogenetic protein (Bmp) signaling produces bicuspid teeth in the zebrafish (Danio rerio), a species lacking multicuspid teeth in its ancestry. The generality of these results for teleosts is suggested by the conversion of unicuspid pharyngeal teeth into bicuspid teeth by similar manipulations of the Mexican Tetra (Astyanax mexicanus). That these manipulations also produced supernumerary teeth in both species supports previous suggestions of similarities in the molecular control of tooth and cusp number. We conclude that despite their apparent complexity, the evolutionary origin of multicuspid teeth is positively constrained, likely requiring only slight modifications of a pre-existing mechanism for patterning the number and spacing of individual teeth.

Original languageEnglish (US)
Pages (from-to)107-118
Number of pages12
JournalEvolution and Development
Volume15
Issue number2
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

Fingerprint

bone morphogenetic proteins
fibroblast growth factors
Bone Morphogenetic Proteins
Fibroblast Growth Factors
teleost
tooth
bone
Tooth
teeth
Fishes
protein
fish
Bicuspid
Zebrafish
Danio rerio
Supernumerary Tooth
Sharks
Lizards
Amphibians
shark

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Developmental Biology

Cite this

Jackman, W. R., Davies, S. H., Lyons, D. B., Stauder, C. K., Denton-Schneider, B. R., Jowdry, A., ... Stock, D. W. (2013). Manipulation of Fgf and Bmp signaling in teleost fishes suggests potential pathways for the evolutionary origin of multicuspid teeth. Evolution and Development, 15(2), 107-118. https://doi.org/10.1111/ede.12021

Manipulation of Fgf and Bmp signaling in teleost fishes suggests potential pathways for the evolutionary origin of multicuspid teeth. / Jackman, William R.; Davies, Shelby H.; Lyons, David B.; Stauder, Caitlin K.; Denton-Schneider, Benjamin R.; Jowdry, Andrea; Aigler, Sharon R.; Vogel, Scott A.; Stock, David W.

In: Evolution and Development, Vol. 15, No. 2, 01.03.2013, p. 107-118.

Research output: Contribution to journalArticle

Jackman, WR, Davies, SH, Lyons, DB, Stauder, CK, Denton-Schneider, BR, Jowdry, A, Aigler, SR, Vogel, SA & Stock, DW 2013, 'Manipulation of Fgf and Bmp signaling in teleost fishes suggests potential pathways for the evolutionary origin of multicuspid teeth', Evolution and Development, vol. 15, no. 2, pp. 107-118. https://doi.org/10.1111/ede.12021
Jackman, William R. ; Davies, Shelby H. ; Lyons, David B. ; Stauder, Caitlin K. ; Denton-Schneider, Benjamin R. ; Jowdry, Andrea ; Aigler, Sharon R. ; Vogel, Scott A. ; Stock, David W. / Manipulation of Fgf and Bmp signaling in teleost fishes suggests potential pathways for the evolutionary origin of multicuspid teeth. In: Evolution and Development. 2013 ; Vol. 15, No. 2. pp. 107-118.
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